ABSTRACT
The expression of substance P (SP) and its NK-1 receptor (NK-1R) in keratocystic odontogenic tumours (KOTs) was studied to determine whether the intrinsic growth potential of these lesions is related to a cell proliferation stimulus mediated by the SP/NK-1R complex. A total of 65 tissue samples of solitary non-recurrent KOTs, solitary recurrent KOTs, KOTs associated with nevoid basal cell carcinoma syndrome (NBCCS) and KOTs with chondroid wall were studied by immunohistochemistry, using anti-SP, anti-NK-1R and anti-Ki-67 monoclonal antibodies. Expression of these markers was analysed in infiltrating lymphocytes, in fibrous capsule, and in membrane, cytoplasm and nucleus of epithelial cells. SP expression in infiltrating lymphocytes was significantly associated with SP in fibrous capsule and epithelial cells. KOTs associated with NBCCS showed a significantly higher SP expression in all tissues and cell compartments compared with other KOT types. Finally, SP expression in epithelial cells was associated with positive Ki-67 expression in dysplastic epithelium. This first published report on SP and NK-1R expressions in KOTs demonstrates that actions of the SP/NK-1R complex may constitute a mechanism to stimulate epithelial cell proliferation in KOT. This pathway may be of special relevance in the multiple KOTs associated with NBCCS.
Subject(s)
Carcinoma, Basal Cell/metabolism , Neoplasm Proteins/metabolism , Odontogenic Tumors/metabolism , Receptors, Neurokinin-1/metabolism , Substance P/metabolism , Adult , Carcinoma, Basal Cell/genetics , Cell Proliferation/drug effects , Epithelial Cells/metabolism , Female , Gene Expression Regulation, Neoplastic/genetics , Humans , Immunohistochemistry , Male , Neoplasm Proteins/genetics , Odontogenic Tumors/genetics , Receptors, Neurokinin-1/genetics , Substance P/geneticsABSTRACT
Odontogenic cysts (OC) are one of the main causes of jaw destruction. Information about these lesions in the Mexican population is scant. And for this reason the purpose of this work is to describe the frequency of the different varieties of OC recorded in two oral pathology services in Mexico City. As well as to compare the findings with those previously reported in other studies and to analyze the association of these lesions with the gender of the affected patients and the type of oral pathology service. There were a total of 856 OC; of these, 449 (52.5%) occurred in men, 403 in women (47%), and in 4 cases (0.5%) gender was not stated. There were 8 out of the 10 different types of OC recognized by the WHO. The most frequently diagnosed OC were radicular cyst (342 cases), dentigerous cyst (283 cases) and odontogenic keratocyst (184 cases). Together, these three entities represented 94.5% of all OC. Both the gender and the type of oral pathology service showed a significant association with radicular and dentigerous cysts (p<0.01). The knowledge of the origin, clinico-pathological features and the biological behavior of these lesions are basic aspects to achieve an early diagnosis and a proper treatment.
Subject(s)
Mandibular Diseases/epidemiology , Maxillary Diseases/epidemiology , Odontogenic Cysts/epidemiology , Female , Humans , Male , Mandibular Diseases/pathology , Maxillary Diseases/pathology , Odontogenic Cysts/pathologySubject(s)
Granuloma, Giant Cell/diagnosis , Mandibular Diseases/diagnosis , Mandibular Neoplasms/diagnosis , Odontogenic Tumors/diagnosis , Adolescent , Female , Granuloma, Giant Cell/pathology , Granuloma, Giant Cell/surgery , Humans , Immunohistochemistry , Keratins/metabolism , Mandible/metabolism , Mandible/pathology , Mandible/surgery , Mandibular Diseases/pathology , Mandibular Diseases/surgery , Mandibular Neoplasms/pathology , Mandibular Neoplasms/surgery , Odontogenic Tumors/pathology , Odontogenic Tumors/surgeryABSTRACT
Three cases of cartilaginous choristomas of the tongue are presented. Two lesions occurred in women of 71 and 28 years of age whose lesions were located in the middle third of the dorsum. The other lesion was found on the left lateral border in a 27-year-old man. The clinical, microscopic and immunohistochemical features are described. The lesions were easily excised with no recurrence after follow-up periods of at least 6 months. The histogenesis and the differential diagnosis are discussed, and the literature is reviewed.
