Subject(s)
Aspergillosis , Hematopoietic Stem Cell Transplantation , Intussusception , Transplantation, Autologous , Humans , Hematopoietic Stem Cell Transplantation/adverse effects , Aspergillosis/drug therapy , Aspergillosis/microbiology , Aspergillosis/complications , Intussusception/etiology , Intussusception/surgery , Intussusception/microbiology , Male , Antifungal Agents/therapeutic use , Middle Aged , Female , Immunocompromised HostABSTRACT
Histoplasmosis is an expected endemic mycosis in solid organ transplant recipients and occurs as a primary infection, reactivation, or, rarely, acquired from an infected allograft. Reactivation is favored by maintenance immunosuppression or anti-rejection therapy, which facilitates the appearance of disseminated forms as well as unusual presentations. We present the case of a 66-year-old woman with isolated tenosynovitis due to Histoplasma capsulatum 25 years after a kidney transplant.
Subject(s)
Histoplasma , Histoplasmosis , Kidney Transplantation , Tenosynovitis , Humans , Kidney Transplantation/adverse effects , Histoplasmosis/diagnosis , Histoplasmosis/drug therapy , Histoplasmosis/microbiology , Histoplasma/isolation & purification , Female , Aged , Tenosynovitis/microbiology , Tenosynovitis/drug therapy , Antifungal Agents/therapeutic use , Immunocompromised Host , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/therapeutic use , Transplant RecipientsABSTRACT
There is increasing recognition that respiratory viral infections such as influenza, respiratory syncytial virus, parainfluenza virus, adenovirus, and SARS-CoV-2 can promote the development of invasive fungal pulmonary coinfections, particularly invasive aspergillosis, both in immunocompetent and immunocompromised patients. To date, there are no case reports exploring the role of human metapneumovirus as a risk factor for fungal coinfection. Below, we describe the case of a 63-year-old woman who received a kidney transplant and developed invasive pulmonary aspergillosis after a human metapneumovirus infection and discuss the possible phenomena that could favor this association.