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1.
JAMA Dermatol ; 159(11): 1279-1281, 2023 11 01.
Article in English | MEDLINE | ID: mdl-37755867

ABSTRACT

This case report describes 3 patients with limited cutaneous systemic sclerosis who were found to have telangiectasias affecting the vulva and the inguinal folds.


Subject(s)
Scleroderma, Systemic , Telangiectasis , Humans , Female , Telangiectasis/diagnosis , Telangiectasis/etiology , Scleroderma, Systemic/complications , Scleroderma, Systemic/diagnosis , Genitalia
2.
Skinmed ; 19(2): 142-144, 2021.
Article in English | MEDLINE | ID: mdl-33938439

ABSTRACT

A 45-year-old brown-skinned woman presented with a 5-year history of asymptomatic grayish brown lesions on the face, arms, and legs. She had no medical history of previous diseases or contact dermatitis. She revealed that she had used olive oil all over her body for the last 8 years every other day. Physical examination showed multiple, well-defined, oval-shaped, dark brown, smooth-surfaced macules with no elevated active borders (Figure 1). There were no associated lesions on the nails, scalp, or mucosae. Serologic tests for autoantibodies and hepatitis A, B, and C virus infections were non-reactive. A patch test for olive oil was also negative. A skin biopsy revealed epidermal atrophy, orthokeratosis, basal cell vacuolation, and a band-like lymphocytic infiltrate in the upper portion of the dermis with abundant colloid bodies and pigmentary incontinence in the papillary dermis (Figure 2). A diagnosis of lichen planus pigmentosus (LPP) was confirmed, and betamethasone butyrate propionate was applied for 2 months over the lesions, with a limited therapeutic effect. Clinical improvement was seen only after she discontinued the olive oil application (Figure 3).


Subject(s)
Anti-Inflammatory Agents/therapeutic use , Hydrocortisone/analogs & derivatives , Lichen Planus/diagnosis , Lichen Planus/drug therapy , Olive Oil/adverse effects , Biopsy , Female , Humans , Hydrocortisone/therapeutic use , Lichen Planus/etiology , Lichen Planus/pathology , Middle Aged , Risk Assessment
4.
Article in English | MEDLINE | ID: mdl-33580925

ABSTRACT

Darier disease (DD) is a rare type of inherited keratinizing disorder with no definitive therapeutic approach. The objective of this study is to provide a detailed literature review of all the available treatment modalities of Darier disease, including those that are both surgical and non surgical, to compare their efficacies and to propose a novel therapeutic approach. A complete search of the literature for all articles describing the different treatments of Darier disease, with no restrictions on patients' ages, gender or nationalities, was performed with the use of PubMed. A total of 68 articles were included in the study: 3 prospective studies, 44 case reports/case series and 21 letters/correspondences/clinical images. The treatments described were topical, oral or physical. Retinoids (isotretinoin, tazarotene and adapalene) and fluorouracil were the two most effective topical treatments. Oral retinoids were the most effective oral therapy and were prescribed in the cases of generalized Darier disease. For localized and resistant skin lesions, physical therapies including surgical excision, dermabrasion and CO2 laser ablation were the first line choices. Limitations of this article include the inability to verify the accuracy of the published data, the relatively small sample size, the absence of randomized controlled clinical trials and possible unidentified confounding factors in various studies. In every therapeutic approach to Darier disease, consideration of patient comorbidities, disease distribution, severity and treatment accessibility is essential. Large and randomized clinical trials are necessary for the comparison of the efficacy and the safety of all the treatments of Darier disease and settling a consensus for management.


Subject(s)
Darier Disease/therapy , Administration, Topical , Algorithms , Botulinum Toxins , Cetirizine/therapeutic use , Cyclosporine/therapeutic use , Dermabrasion , Diclofenac/therapeutic use , Dihydroxycholecalciferols/therapeutic use , Doxycycline/therapeutic use , Drug Combinations , Electrosurgery , Ethinyl Estradiol/therapeutic use , Fatty Acids/therapeutic use , Fluorouracil/therapeutic use , Glucocorticoids/therapeutic use , Humans , Lasers , Levonorgestrel/therapeutic use , Magnesium Chloride/therapeutic use , Naltrexone/therapeutic use , Photochemotherapy , Retinoids/therapeutic use , Tacrolimus/therapeutic use
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