ABSTRACT
Recent reports have suggested that serum creatine kinase isoenzyme BB (CK-BB) may be used as a tumor marker for a variety of malignancies, particularly prostatic carcinoma. Two cases of small cell anaplastic carcinoma of the lung (SCAC) had markedly contrasting levels of CK-BB by serum electrophoresis. Retrospective analysis of the index cases, and four additional autopsy cases of SCAC, included: 1) quantitation of CK-B in postmortem tumor and adjacent non-tumor lung tissue; 2) enzymatic and radioimmunoassay serum levels of CK-B; and 3) CK-B immunoperoxidase staining of tumor and non-tumor tissues for CK-B. Serum CK-BB is a non-specific tumor marker, but its presence, in whatever amount, should alert the clinician to the possibility of an associated malignancy, particularly SCAC or metastatic carcinoma.
Subject(s)
Biomarkers, Tumor/blood , Carcinoma, Small Cell/enzymology , Creatine Kinase/blood , Lung Neoplasms/enzymology , Aged , Female , Humans , IsoenzymesABSTRACT
In recent years, immunoperoxidase staining of fine needle aspirates has been proposed. This study examines the use of immunoperoxidase staining of prostatic acid phosphatase and prostatic specific antigen in two cases where differentiation of prostatic carcinoma from other carcinomas manifesting as metastatic lesions is essential. The histologic differentiation of primary and metastatic disease, which has significant therapeutic and prognostic implications, has been enhanced by the use of immunoperoxidase staining. The presented cases demonstrate the ease with which immunoperoxidase staining can be done in a community hospital.
Subject(s)
Adenocarcinoma/immunology , Lung Neoplasms/secondary , Prostatic Neoplasms/immunology , Adenocarcinoma/metabolism , Humans , Immunohistochemistry , Lung Neoplasms/immunology , Lung Neoplasms/metabolism , Male , Prostatic Neoplasms/metabolismSubject(s)
Antigens, Neoplasm/analysis , Creatine Kinase/blood , Lung Neoplasms/diagnosis , Humans , IsoenzymesABSTRACT
Palm wine is the sap of palm tree (family Palmeae) obtained as the fermentation product of a 24 hour tapping. The effect was studied in 40 albino rats of both sexes. It was found that palm wine per orally caused 21.8% decrease in gastric acid secretion (P less than 0.01). But 4% ethanol caused significant increase, while 12% sucrose caused significant decrease in gastric acid secretion in rats. This inhibitory effect of palm wine may be of clinical significance in the management of peptic ulcer patients and ulcer prone subjects in this region.
Subject(s)
Gastric Acid/metabolism , Wine , Animals , Depression, Chemical , Female , Male , Nigeria , RatsABSTRACT
We measured serum prostatic acid phosphatase in ostensibly normal controls and a selected patient population, using both a modified radioimmunoassay and an enzymic method with thymolphthalein monophosphate as substrate. The upper limit of normal for the radioimmunoassay was 2.2 micrograms/L; its sensitivity and specificity for prostatic cancer were 71 and 95%, respectively, vs 51 and 99% for the enzymic method. For both methods the correlation between clinical staging and values for acid phosphatase was poor. Our data suggest that adjunctive use of the radioimmunoassay may help further discriminate those patients requiring needle biopsy.
