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3.
Infect Immun ; 40(1): 417-20, 1983 Apr.
Article in English | MEDLINE | ID: mdl-6601062

ABSTRACT

Congenitally athymic (nu/nu) mice were found to be more susceptible to intravenous challenge with Sporothrix schenckii than their phenotypically normal (nu/+) littermates as measured by lethality and the number of viable yeast cells in the liver 7 days postinfection. Thymus reconstitution of nu/nu mice (nu/thy) conferred a significant degree of resistance to sporotrichosis. Immunization greatly enhanced the resistance of nu/thy and nu/+ mice, but unexpectedly increased the susceptibility of nu/nu mice. The susceptibility of nonimmunized nu/nu mice and the finding that thymus transplants augmented resistance to sporotrichosis suggest that T lymphocytes are critical to host defense.


Subject(s)
Mice, Nude/immunology , Sporotrichosis/immunology , Animals , Disease Susceptibility , Female , Hypersensitivity, Delayed/immunology , Male , Mice , Mice, Inbred BALB C , Sporotrichosis/microbiology , Sporotrichosis/mortality , T-Lymphocytes/immunology
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