[Effect of antiadrenergic and myotropic hypotensive agents on the blood kallikrein-kinin system in experimental hypertension]. / Vliianie antiadrenergicheskikh i miotropnykh gipotenzivnykh sredstv na kallikrein-kininovuiu sistemu krovi pri éksperimental'noi gipertenzii.

In the period of vasorenal hypertension formation in rats phase changes in the kallikrein-kinin system of the blood are observed: one month after kidney-skin anastomosis a significant increase of the levels of prekallikrein, kininogen and kallikrein inhibitor is noted and by the end of the second month a drastic decrease of the levels of these components occurs due to the "unregulated" activation of the kallikrein-kinin system of the blood. Antiadrenergic agents (reserpine, tropaphen) prescribed for treatment of hypertension prevent the development of the "unregulated" activation of the kallikrein-kinin system and reduce consumption of its components. These drugs are advisable to use under threat of the kallikrein-kinin system exhaustion. beta-adrenoblocking agent obsidan and myotropic drugs produce a significant enhancement of kallikreino- and kininogenesis, but the degree of activation of the processes is less pronounced than in untreated hypertensive rats.

[Clinical and experimental study of the effect of obsidan and hemiton on the blood kallikrein-kinin system]. / Kliniko-éksperimental'noe izuchenie vliianiia obzidana i gemitona na kallikrein-kininovuiu sistemu krovi.

In 52 patients with labile hypertension and also in experimental hypertension in 52 rats dynamics of kallikrein-kinin system in the blood during obsidan and hemiton treatment has been studied to find relationship between the hypotensive action of these drugs and the blood kinins activity. It was found that there exist counter-directional shifts in the kallikrein-kinin system of the blood as a result of treatment depending on their initial level. Adequate therapy contributed to the maintenance of optimum kinin concentration for preservation of homeostasis. With hypertensive syndrome supervening in rats increase of kinin predecessor synthesis has been recorded. Chronic administration of obsidan (0.5 mg/kg) and hemiton (0.1 mg/kg for 20 days increased kininogenesis).