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Prolyl endopeptidase and thrombin inhibitory diterpenoids from the bark of Xylopia aethiopica.
Diderot, Noungoue Tchamo; Silvere, Ngouela; Yasin, Amsha; Zareen, Seema; Fabien, Zelefack; Etienne, Tsamo; Choudhary, M Iqbal.
Biosci Biotechnol Biochem ; 69(9): 1763-6, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16195597

ABSTRACT

The inhibitory effects of seven diterpenes, belonging to three different structural classes and isolated from the bark of Xylopia aethiopica, were investigated against the enzymes prolyl endopeptidase (PEP) and alpha-thrombin. Five compounds exhibited inhibitory activity against them.


Subject(s)
Annonaceae/enzymology , Anticoagulants/therapeutic use , Diterpenes/therapeutic use , Phytotherapy , Serine Endopeptidases/therapeutic use , Thrombin/antagonists & inhibitors , Animals , Anticoagulants/chemistry , Diterpenes/chemistry , Diterpenes/classification , Drug Evaluation, Preclinical , Inhibitory Concentration 50 , Plant Bark/chemistry , Prolyl Oligopeptidases
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