ABSTRACT
The use of computer and magnetic-resonance therapy permits high accuracy visualization of tumor lesion zone in patients with pelvic bone tumors. More precise results concerning lesion zones before surgical intervention have been obtained in cases of 3D modeling use. OBJECTIVE: improvement of surgical treatment results due to determination of the optimal level for pelvic bone resection. MATERIALS AND METHODS: Cohort study was realized using 3D modeling based on computer tomography data applying the software packet RadiAnt DICOM Viewer with 3D Volume Rendering and the software packet «SolidWorks¼. Two patient groups were investigated: 1) 13 patients without preliminary preoperative 3D modeling (control group) and 2) 14 patients with modeling (main group). In both groups relapse-free survival and age-dependent survival were evaluated. RESULTS AND DISCUSSION: Tumor relapses were found in 6 patients (46.15 %) of control group and in 5 patients (33.33 %) of the main group. No statistically significant difference between groups concerning relapse-free survival results was detected. In both groups, medians of relapse-free survival were not obtained, two-year long relapse-free survival reaching (53.8 ± 13.8) % and (66.7 ± 12.2) % in control and main groups, respectively. Analyzing the cor- relation between patients age and results obtained the authors demonstrated the two-year relapse-free survival to reach (47.4 ± 11.5) % and (88.9 ± 10.5) % in patients aged above 40 and below 40, respectively (p = 0,06). CONCLUSION: Because of small sample sizes in both groups, the use of 3D modeling does not demonstrate any signif- icant difference regarding two-year relapse-free survival. However, there is a tendency for further progress. The search of approaches for improvement of the treatment results for pelvic bone tumor patients remains among the most important study problem in current orthopedics for tumor patients.
Subject(s)
Bone Neoplasms/surgery , Pelvic Bones/surgery , Pelvic Neoplasms/surgery , Pelvis/surgery , Surgery, Computer-Assisted/methods , Adult , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/mortality , Bone Neoplasms/pathology , Cohort Studies , Female , Humans , Imaging, Three-Dimensional , Magnetic Resonance Imaging , Male , Middle Aged , Pelvic Bones/diagnostic imaging , Pelvic Bones/pathology , Pelvic Neoplasms/diagnostic imaging , Pelvic Neoplasms/mortality , Pelvic Neoplasms/pathology , Pelvis/diagnostic imaging , Pelvis/pathology , Recurrence , Survival Analysis , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
On the basis of experimental-and-clinical investigations it has been found out that the home-produced hydroxylapatite (HA)- and tricalciumphosphate(TCP)-based ceramic material is capable owing to specificities of its chemical structure and osteoinductive action of stimulating the reparative osteogenesis and is accompanied by angiogenesis. No ill effects have been noted in its use in bone plastic surgery. An apparent clinical effect has been shown to occur in postsurgical patients (n = 120) presenting with giant cell tumour, benign tumours and tumour-like affections of the bones, with the expediency having been ascertained of employment of the HA- and TCP-base ceramic material in the treatment of the above patients. The use of the above materials implants versus allotransplants promotes decline in the percentage of complications (1.66 vs 27.2), shortening of time of medical rehabilitation of patients by two to three months as compared to allotransplantation as well as hospital stay duration (by 10 to 12 days).
Subject(s)
Bone Neoplasms/therapy , Calcium Phosphates/chemistry , Ceramics/therapeutic use , Durapatite/chemistry , Prostheses and Implants , Biocompatible Materials/therapeutic use , Bone Neoplasms/pathology , Cohort Studies , Humans , Length of Stay , Male , Neovascularization, Physiologic , Osteogenesis , Postoperative PeriodABSTRACT
It has been established in an experimental setting in laboratory animals through testing a number of reactions such as active skin anaphylaxis reaction, mast cell degranulation reaction, specific leucocyte lysis reaction, delayed hypersensitivity reaction, and graft-versus-host reaction that ceramic preparations hydroxilapatite M and osteogel-7 have no sensitizing effects; osteogel-7 is not endowed with immunomodulating activity, which fact suggests to us its immunological inertness.