1.
Chem Commun (Camb)
; 52(22): 4187-90, 2016 Mar 18.
Article
in English
| MEDLINE
| ID: mdl-26906286
ABSTRACT
3,4-Diaminopyridine has shown promise in reversing botulinum intoxication, but poor pharmacokinetics and a narrow therapeutic window limit its clinical utility. Thus, we developed a pH-dependent oral delivery platform using club moss spore exines. These exine microcapsules slowed 3,4-diaminopyridine absorption, limited its seizure activity, and enabled delivery of doses which prolonged mouse survival after botulism neurotoxin A intoxication.