ABSTRACT
We present a newborn diagnosed with posterior amorphous corneal dystrophy (PACD). PACD is a rare disorder with partial or complete posterior lamellar corneal opacification. Genetic screening showed a deletion of chromosome 12q21.33-q22 containing the identified four small leucine-rich proteoglycans (SLRP's) associated with this particular dystrophy. Neither parents were carrier of the deletion. To our knowledge, this is the first report of a de novo mutation causing PACD.
Subject(s)
Chromosome Deletion , Chromosomes, Human, Pair 12 , Corneal Dystrophies, Hereditary/genetics , Small Leucine-Rich Proteoglycans/genetics , Adult , Comparative Genomic Hybridization , Corneal Dystrophies, Hereditary/diagnosis , Female , Humans , Infant , Oligonucleotide Array Sequence AnalysisABSTRACT
Torsional diplopia may frequently accompany Graves' orbitopathy and is often not recognized. Some patients with manifest cyclotorsion do not complain of torsional diplopia because it is concealed by the large vertical and/or horizontal deviation. Torsional diplopia can occur spontaneously or appear after decompression or strabismus surgery. We discuss some interesting points arising from three cases. This will be followed by a discussion of the literature on the pathogenesis of cyclodeviation in Graves' orbitopathy.
Subject(s)
Diplopia/etiology , Graves Disease/complications , Aged , Diplopia/therapy , Female , Humans , Male , Middle Aged , Oculomotor Muscles/surgery , Torsion AbnormalityABSTRACT
A group of 79 prematurely born children was assessed ophthalmologically at the age of 12 and compared with a group of 100 12 years old children born at term. Of the 79 children, results of neonatal eye examinations were available in 26 prematures (52 eyes). In 28 eyes no signs of retinopathy of prematurity (ROP) were detected (non-ROP group). In 24 eyes a stage 1 or 2 retinopathy of prematurity was present (ROB group). 75% of the children with ROP had an ophthalmological problem. Myopia (29%), hypermetropia (21%), astigmatism (37%) and strabismus (33%) were significantly higher. Considering the whole group of prematurely born children, there was more astigmatism (11%) and strabismus (13%). Preterm children, with or without ROP, are more prone to develop ocular problems.
Subject(s)
Retinopathy of Prematurity/diagnosis , Vision Disorders/diagnosis , Adolescent , Child , Humans , Infant, Newborn , Male , Refractive Errors/diagnosis , Strabismus/diagnosis , Visual AcuitySubject(s)
Iatrogenic Disease , Light/adverse effects , Microsurgery/adverse effects , Retina/injuries , Adult , Aged , Aged, 80 and over , Female , Humans , Middle AgedABSTRACT
Topical administration of 0.1% or 1% chloroethyldeoxyuridine eyedrops caused a significant reduction in the severity of experimental herpes simplex iritis and stromal keratitis in rabbits. The healing effect caused by chloroethyldeoxyuridine was comparable to that obtained with 0.1% and 0.5% bromovinylde-oxyuridine eyedrops. The drug levels achieved in the anterior chamber fluid following topical application of 1% eyedrops of [2-14C]CEDU, a radiolabelled analogue of chloroethyldeoxyuridine, were well above the minimum concentration (0.1 microgram/mL) required for inhibition of herpes simplex virus type 1 replication. The beneficial effects of chloroethyldeoxyuridine on stomal keratitis and iritis appear consistent with its efficient penetration through the cornea.
