ABSTRACT
Case of bronchogenic cyst associated with extralobar pulmonary sequestration is presented in a 10-month-old baby. At thoracotomy, the tumor was an extralobar pulmonary sequestration with a central cyst surrounded by two pulmonary lobes vascularised by systemic vessels. Resection was easy. The cyst had a respiratory mucosa and was benign. The pathogenesis of the malformation is discussed.
Subject(s)
Bronchogenic Cyst/complications , Bronchopulmonary Sequestration/etiology , Bronchogenic Cyst/diagnostic imaging , Bronchogenic Cyst/surgery , Bronchopneumonia/etiology , Bronchopulmonary Sequestration/diagnostic imaging , Bronchopulmonary Sequestration/surgery , Female , Humans , Infant , Radiography , ThoracotomyABSTRACT
Two years after opening the Dakar Trauma Center has received 179 cases of blunt chest trauma without prehospital treatment. Road accidents were the leading cause. The initial mortality was 29 patients (16.20%) and 150 patients arrived alive and were treated. The initial mortality was primarily due to the associated extrathoracic injuries mainly hemorrhagic with hemoperitoneum in 44.82% and brain hemorrhage in 24.14% of cases. Secondly, it was due to the thoracic injuries with 41.37% of anterior flail chest and massive hemothorax in 65.51% of cases. Among the 150 patients treated, 42% had extrathoracic injuries, mainly head trauma. 56% were admitted to intensive care units with 39 chest drainages and 6 thoracotomies were performed. The mortality in this group was about 11.33%. The very high initial mortality could be reduced by the organisation of prehospital treatment to take better care of patients involved in road accidents.
Subject(s)
Cerebral Hemorrhage/mortality , Hemoperitoneum/mortality , Hemothorax/mortality , Rib Fractures/complications , Thoracic Injuries/mortality , Accidents, Traffic , Adolescent , Adult , Aged , Cerebral Hemorrhage/etiology , Child , Female , Hemoperitoneum/etiology , Hemothorax/etiology , Humans , Lung Diseases/etiology , Lung Diseases/surgery , Male , Middle Aged , Pleural Effusion/etiology , Pleural Effusion/surgery , Senegal/epidemiology , Thoracic Injuries/complications , Thoracic Injuries/surgeryABSTRACT
Antibiotherapy in surgery leads to a large amount of money expenses from the budget of hospitals according to many authors. So a short time well adapted antibioprophylaxis may be a better choice in gastroduodenal surgery. In a two years (July 1991-June 1993) prospective study in seventeen patients with stenosis on hemorragea complicating their gastroduodenal ulcer, 2 grs of Cefazoline are prior to surgery at induction first and then 1 gr each following 3 hours, until the end of the procedure in Orthopedics and Traumatology Hospital in DAKAR. At assessment the early results are good, without any superficial or deep infection. In comparison the length of admission was shorter. Despite our few cases, we strongly believe that antibioprophylaxis in gastroduodenal surgery using Cefazolin may be recommended.
Subject(s)
Cefazolin/therapeutic use , Peptic Ulcer/surgery , Premedication , Adolescent , Adult , Bacterial Infections/prevention & control , Cefazolin/administration & dosage , Female , Humans , Male , Middle Aged , Prospective StudiesABSTRACT
Because it is a common prerequisite for steroid responsiveness in target tissue, we investigated the presence of specific 1,25-DR in spontaneous human colorectal adenocarcinomas (ADC) and adjacent normal-appearing mucosa (NAM) from 23 operative specimens (12 male and 11 female patients). 1,25-DR was determined in cytosol by a DCC assay technique. 1,25-DR was present in 21 of 23 NAM and in only 4 of 23 HCRA. All positive ADC were well differentiated. Receptor content expressed in femtomoles/mg of protein (mean +/- SEM) was respectively 63.9 +/- 7.6 for right colon NAM and 51.3 +/- 12.9 for left colon or rectum NAM. When we compared all NAM specimens, receptor content was 56.7 +/- 8.0 femtomoles/mg of protein. No difference in 1,25-DR NAM level was observed between right colon and left colon or rectum. In adenocarcinoma the mean content was 66.5 +/- 14 fmoles/mg of protein. Scatchard analysis showed a single class of specific high-affinity saturable 1,25-DR with a dissociation constant (Kd) of 0.97 +/- 0.57 and 1.03 +/- 0.39 chi 10(-10) M in NAM and ADC respectively. These preliminary data represent the first demonstration of 1,25-DR throughout the entire human colon and indicate that the receptivity for this hormone is often lost during malignant transformation of the human colorectal mucosa. In addition, 1,25-DR could be a marker of differentiation in ADC. These preliminary results provide evidence supporting the addition of Vitamin D to the roster of developmental cancer chemopreventative agents.
