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Association between dopa decarboxylase gene variants and borderline personality disorder.

Mobascher, Arian; Bohus, Martin; Dahmen, Norbert; Dietl, Lydie; Giegling, Ina; Jungkunz, Martin; Kleindienst, Nikolaus; Limberger, Matthias; Meisenzahl, Eva; Rietschel, Marcella; Roepke, Stefan; Schmahl, Christian; Schott, Björn; Schwarze, Cornelia E; Tadic, André; Treutlein, Jens; Vogel, Friederike; Witt, Stephanie H; Zetzsche, Thomas; Rujescu, Dan; Lieb, Klaus.

Psychiatry Res ; 219(3): 693-5, 2014 Nov 30.

Article in English | MEDLINE | ID: mdl-25017620

ABSTRACT

Despite heritability estimates of 37-69%, research has identified few genetic risk variants for borderline personality disorder (BPD). The present collaborative candidate gene study of 987 BPD cases and 1110 healthy controls found an association between BPD and single nucleotide polymorphism rs12718541 in the dopa decarboxylase gene.

Subject(s)

Borderline Personality Disorder/epidemiology , Borderline Personality Disorder/genetics , Dopa Decarboxylase/genetics , Polymorphism, Single Nucleotide/genetics , Adult , Alleles , Borderline Personality Disorder/diagnosis , Case-Control Studies , Female , Genetic Variation , Humans , Male , Middle Aged

ABSTRACT

Subject(s)

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