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Bioorg Med Chem Lett
; 20(7): 2163-7, 2010 Apr 01.
Article
in English
| MEDLINE
| ID: mdl-20202838
ABSTRACT
Substituted pyridazino[4,5-b]indolizines were identified as potent and selective PDE4B inhibitors. We describe the structure-activity relationships generated around an HTS hit that led to a series of compounds with low nanomolar affinity for PDE4B and high selectivity over the PDE4D subtype.