Subject(s)
Diagnostic Imaging/instrumentation , Image Processing, Computer-Assisted/methods , Practice Patterns, Physicians'/statistics & numerical data , Remote Consultation/statistics & numerical data , Clinical Decision-Making , Computer Security/ethics , Diagnostic Imaging/statistics & numerical data , Humans , Infant , Male , Parents , Pediatrics/statistics & numerical data , Photography , Practice Patterns, Physicians'/ethics , Role Playing , State Medicine/organization & administration , United Kingdom/epidemiologyABSTRACT
Bone health in children with osteogenesis imperfecta is monitored using radiographs and dual-energy X-ray absorptiometry, which have limitations. High-resolution peripheral quantitative CT can non-invasively derive bone microarchitectural data. Children with severe osteogenesis imperfecta have fragile deformed bones, and positioning for this scan can be difficult. We assessed the feasibility of high-resolution peripheral quantitative CT in nine children aged 9-15 years with osteogenesis imperfecta and compared results with dual-energy X-ray absorptiometry and with healthy controls. All nine recruited children were successfully scanned and showed no preference for either modality. It therefore appears feasible to perform high-resolution peripheral quantitative CT in children with osteogenesis imperfecta aged 9 years and older. Future studies should focus on understanding the clinical implications of the technology in this patient cohort.
