ABSTRACT
The effects of sildenafil on heart rate variability were investigated in 20 healthy male subjects aged 24 (21 to 32) years (median; range). Subjects orally received single 100-mg doses of sildenafil and placebo under randomized double-blind crossover conditions on 2 separate study days. Time domain measures of heart rate variability were assessed under conditions of relaxed rest, metronomic breathing (6 cycles per minute), and bicycle ergometry before administration of sildenafil and placebo as well as 60 minutes afterwards. Sildenafil did not alter heart rate nor heart rate variability to a significant extent (P > 0.05).
Subject(s)
Heart Rate/drug effects , Piperazines/pharmacology , Sulfones/pharmacology , Adult , Cross-Over Studies , Double-Blind Method , Electrocardiography , Exercise Test , Heart Rate/physiology , Humans , Male , Purines/pharmacology , Respiration , Rest/physiology , Sildenafil Citrate , Supine Position/physiology , Vasodilator Agents/pharmacologyABSTRACT
In this placebo controlled double blind cross over study multiple daily dosing with 500 mg acetylic salicylic acid did not influence heart rate variability in 16 healthy male volunteers aged 25 (22-28) years (median; range) to a relevant extent (p > 0.05).
