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2.
Brain ; 145(6): 1906-1915, 2022 06 30.
Article in English | MEDLINE | ID: mdl-35472071

ABSTRACT

Persistent symptoms following a minor head injury can cause significant morbidity, yet the underlying mechanisms for this are poorly understood. The shortcomings of the current terminology that refer to non-specific symptom clusters is discussed. This update considers the need for a multi-dimensional approach for the heterogenous mechanisms driving persistent symptoms after mild traumatic brain injury. Relevant pathophysiology is discussed to make the case for mild traumatic brain injury to be conceptualized as an interface disorder spanning neurology, psychiatry and psychology. The relevance of pre-injury factors, psychological co-morbidities and their interaction with the injury to produce persistent symptoms are reviewed. The interplay with psychiatric diagnoses, functional and somatic symptom disorder presentations and the influence of the medicolegal process is considered. The judicious use and interpretation of investigations given the above complexity is discussed, with suggestions of how the explanation of the diagnostic formulation to the patient can be tailored, including insight into the above processes, to aid recovery. Moving beyond the one-dimensional concept of 'postconcussional syndrome' and reframing the cause of persistent symptoms following mild traumatic brain injury in a bio-psycho-socio-ecological model will hopefully improve understanding of the underlying contributory mechanistic interactions and facilitate treatment.


Subject(s)
Brain Concussion , Mental Disorders , Neurology , Post-Concussion Syndrome , Psychiatry , Brain Concussion/diagnosis , Humans , Mental Disorders/etiology , Post-Concussion Syndrome/diagnosis , Post-Concussion Syndrome/etiology , Post-Concussion Syndrome/psychology
3.
Pract Neurol ; 22(2): 129-137, 2022 Apr.
Article in English | MEDLINE | ID: mdl-34906998

ABSTRACT

Post-traumatic amnesia is the transient state of altered brain function that may follow a traumatic brain injury. At a practical level, an individual has emerged from post-traumatic amnesia when he or she is fully orientated and with return of continuous memory. However, the clinical manifestations are often more complex, with numerous cognitive domains commonly affected, as well as behaviour. In the acute setting, post-traumatic amnesia may easily go unrecognised; this is problematic as it has important implications for both immediate management and for longer-term prognosis. We therefore recommend its careful clinical assessment and prospective evaluation using validated tools. Patients in post-traumatic amnesia who have behavioural disturbance can be particularly challenging to manage. Behavioural and environmental measures form the mainstay of its treatment while avoiding pharmacological interventions where possible, as they may worsen agitation. Patients need assessing regularly to determine their need for further rehabilitation and to facilitate safe discharge planning.


Subject(s)
Brain Injuries, Traumatic , Psychotic Disorders , Amnesia/etiology , Amnesia/psychology , Brain Injuries, Traumatic/complications , Brain Injuries, Traumatic/psychology , Female , Humans , Prognosis
4.
Clin Med (Lond) ; 21(2): e198-e205, 2021 03.
Article in English | MEDLINE | ID: mdl-33762387

ABSTRACT

Following hyperacute management after traumatic brain injury (TBI), most patients receive treatment which is inadequate or inappropriate, and delayed. This results in suboptimal rehabilitation outcome and avoidable detrimental chronic effects on patients' recovery. This worsens long-term disability, and magnifies costs to the individual and society. We believe that accurate diagnosis (at the level of pathology, impairment and function) of the causes of disability is a prerequisite for appropriate care and for accessing effective rehabilitation. An expert-led, integrated care pathway is needed to deliver accurate and timely diagnosis and optimal treatment at all stages during a TBI patient's care.We propose the introduction of a specialist interdisciplinary traumatic brain injury team, led by a neurosciences-trained brain injury consultant. This team would engage acutely and for a longer term after TBI to provide accurate diagnoses, which guides subsequent management and rehabilitation. This approach would also encourage more efficient collaboration between research and the clinic. We propose that the current major trauma network is leveraged to introduce and evaluate this proposal. Improvements to patient outcomes through this approach would lead to reduced personal, societal and economic impact of TBI.


Subject(s)
Brain Injuries, Traumatic , Brain Injuries , Neurosciences , Brain Injuries, Traumatic/diagnosis , Brain Injuries, Traumatic/therapy , Humans , State Medicine , Treatment Outcome
5.
J Neurol ; 267(7): 2164-2172, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32193596

ABSTRACT

Functional neurological disorder (FND) is a common cause of persistent and disabling neurological symptoms. These symptoms are varied and include abnormal control of movement, episodes of altered awareness resembling epileptic seizures and abnormal sensation and are often comorbid with chronic pain, fatigue and cognitive symptoms. There is increasing evidence for the role of neurologists in both the assessment and management of FND. The aim of this review is to discuss strategies for the management of FND by focusing on the diagnostic discussion and general principles, as well as specific treatment strategies for various FND symptoms, highlighting the role of the neurologist and proposing a structure for an interdisciplinary FND service.


Subject(s)
Conversion Disorder/therapy , Disease Management , Nervous System Diseases/therapy , Neurologists , Psychophysiologic Disorders/therapy , Conversion Disorder/diagnosis , Conversion Disorder/physiopathology , Humans , Nervous System Diseases/diagnosis , Nervous System Diseases/physiopathology , Psychophysiologic Disorders/diagnosis , Psychophysiologic Disorders/physiopathology
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