Using machine learning to forecast domestic homicide via police data and super learning.

We explore the feasibility of using machine learning on a police dataset to forecast domestic homicides. Existing forecasting instruments based on ordinary statistical instruments focus on non-fatal revictimization, produce outputs with limited predictive validity, or both. We implement a "super learner," a machine learning paradigm that incorporates roughly a dozen machine learning models to increase the recall and AUC of forecasting using any one model. We purposely incorporate police records only, rather than multiple data sources, to illustrate the practice utility of the super learner, as additional datasets are often unavailable due to confidentiality considerations. Using London Metropolitan Police Service data, our model outperforms all extant domestic homicide forecasting tools: the super learner detects 77.64% of homicides, with a precision score of 18.61% and a 71.04% Area Under the Curve (AUC), which, collectively and severely, are assessed as "excellent." Implications for theory, research, and practice are discussed.

Cbt modulates Foxo activation by positively regulating insulin signaling in Drosophila embryos.

In late Drosophila embryos, the epidermis exhibits a dorsal hole as a consequence of germ band retraction. It is sealed during dorsal closure (DC), a morphogenetic process in which the two lateral epidermal layers converge towards the dorsal midline and fuse. We previously demonstrated the involvement of the Cbt transcription factor in Drosophila DC. However its molecular role in the process remained obscure. In this study, we used genomic approaches to identify genes regulated by Cbt as well as its direct targets during late embryogenesis. Our results reveal a complex transcriptional circuit downstream of Cbt and evidence that it is functionally related with the Insulin/insulin-like growth factor signaling pathway. In this context, Cbt may act as a positive regulator of the pathway, leading to the repression of Foxo activity. Our results also suggest that the DC defects observed in cbt embryos could be partially due to Foxo overactivation and that a regulatory feedback loop between Foxo and Cbt may be operating in the DC context.

Education in burns: Lessons from the past and objectives for the future.

Burns are devastating to the individual and society, representing a huge biomedical burden. Improved education in burns has however ignited a revolution in high-income countries-burn mortality is reducing. Education in burns is far-reaching. For the purpose of this concise review, we focus on four categories: education of both (1) emergency and (2) specialist physicians, and the general population, both at a (3) societal and (4) individual level. Tragically, the global burns picture is bleak with burns representing a neglected but solvable health crisis. Ninety-five percent of burns occur in low-income countries, causing enormous suffering, death and disability. Here, we examine the literature detailing burn education with a focus on past lessons, current trends and future objectives. We have identified key educational objectives to revolutionise burn care on a global perspective. Now is the time to build on promising educational strides to reduce the global burns burden.