[The adequacy of a new method for assessing the vestibular protective effect of biologically active substances]. / Izuchenie adekvatnosti novogo metoda otsenki vestibuloprotektornogo vliianiia biologicheski aktivnykh veshchestv.

The effects of some neuropsychotropic agents on changes in pain sensitivity in albino male rats under the action of complex accelerations were investigated. It was found that administration of drugs with the antimotion-sickness activity--scopolamine, phenamine, phenibut prevented the development of analgesia with the opiate component, the use of low-effective and non-effective with respect to suppression of vestibulo-vegetative disturbances agents--diazepam, ephedrine, haloperidol failed to exert such an effect.

[Antiepileptic drugs in the combined medicinal prevention of motion sickness]. / Protivoépilepticheskie sredstva v kombinirovannoi medikamentoznoi profilaktike bolezni dvizheniia.

Different antiepileptic drugs were tested as ingredients of various combinations for the prophylaxis and therapy of motion sickness. The combinations included diphenine, depakene, diazepam, clonazepam, pantogam and pyracetam. The best antimotion effect was recorded when a combination of diphenine and pantogam was used. This combination prevented disorders of cerebral associative processes induced by simulated motion sickness.

[Pharmacological correction of central nervous system function in exposure to Coriolis acceleration]. / K farmakologicheskoi korrektsii sostoianiia tsentral'noi nervnoi sistemy pri deistvii uskoreniia Koriolisa.

Healthy volunteers with a low vestibular tolerance were exposed to Coriolis acceleration. Potassium orotate, pyracetame and riboxine were used as prophylactic measures against disorders in the function of the vestibular apparatus and higher compartments of the higher nervous system. The central nervous function was assessed with respect to the spectral power of electroencephalograms, short-term memory and mental performance. Potassium orotate given at a dose of 40 mg/kg body weight/day during 12-14 days as well as pyracetame given at a dose of 30 mg/kg body weight/day during 3 or 7 days increased significantly statokinetic tolerance and produced a protective effect on the central nervous function against Coriolis acceleration.

[Neuropharmacology of stress analgesia]. / K neirofarmakologii stress-anal'gezii.

Painful and non-painful stresses have a different line of action on analgetic activity of phentanyl. Hyperalgetic action of immobilization stress is supposed to be linked with impairment of the functioning of the thalamocortical serotonin-sensitive system that gets activated before the development of maximal analgesia in non-stressed cats. Droperidol reduces the antinociceptive action of painful stress. Melipramine and tisercin potentiate stress analgesia.

[Pharmacodynamics of the interaction of neuroleptanalgetics]. / Izuchenie farmakodinamiki vzaimodeistviia neiroleptanal'getikov.

The authors carried out a quantitative assessment of pharmacodynamic effects of droperidol (5 and 25 mg/kg) and phentanyl (0.5 and 1 microgram/kg). The effects of the drugs on sensitivity and pain were studied by the "tail jerking" test. The electrophysiological studies included spectral analysis of the EG of the following central nervous system structures: head of the caudate nucleus, substantia nigra, central gray of the midbrain. The quantitative characteristics of the analgesic effect of phentanyl and hyperalgetic effect of droperidol, as well as the potentiation of the antinociceptive effect of phentanyl combined with droperidol were demonstrated. Studies on the EG recorded the appearance of local extremes on the spectrograms within the range of 7 Hz. The use of the method of least squares for comparing the curves of the relationships between the effects of droperidol and phentanyl and their concentrations in the brain enabled deriving the equations that quantitatively characterize the pharmacodynamic effects of interaction of the drugs in question.