ABSTRACT
Neomycin is coupled on xanthan-a polysaccharide of microbial biosynthesis produced by Xanthomonas campestris-through ionic complexation. The kinetics of neomycin release, in vitro, at pH = 8.2 is studied. A controlled release of neomycin, following a zero order kinetics is observed, regardless of the eluent flow. Neomycin complexed on xanthan, administered in a unique daily dose to patients suffering from dysentery in the 100 cases taken in study, has shown a high clinical efficiency as compared with the treatments with ampicillin or furazolidone, administered for 5-10 days or longer.
Subject(s)
Neomycin/administration & dosage , Adult , Child , Delayed-Action Preparations , Diarrhea/drug therapy , Diarrhea/microbiology , Drug Carriers , Dysentery, Bacillary/drug therapy , Dysentery, Bacillary/microbiology , Feces/microbiology , Humans , Hydrogen-Ion Concentration , Neomycin/pharmacokinetics , Polysaccharides, Bacterial , Salmonella Infections/drug therapy , Salmonella Infections/microbiology , Salmonella typhimurium , Shigella boydii , Shigella flexneri , Shigella sonnei , Time FactorsABSTRACT
Our series includes 27 patients with nosocomial meningitis (22 post neurosurgery and 5 post spinal puncture) of whom 15 with stated etiology (gram-negative bacilli and staphylococcus aureus in equal shares). Under the treatment with chloramphenicol + rifampicin + gentamicin a cure was obtained in 22 cases, improvement in 3 cases and 2 patients died.
Subject(s)
Cross Infection/epidemiology , Meningitis, Bacterial/epidemiology , Postoperative Complications/epidemiology , Acute Disease , Age Factors , Anti-Bacterial Agents/therapeutic use , Cross Infection/drug therapy , Cross Infection/etiology , Drug Therapy, Combination , Humans , Meningitis, Bacterial/drug therapy , Meningitis, Bacterial/etiology , Postoperative Complications/drug therapy , Postoperative Complications/etiology , Romania/epidemiology , Sex Factors , Time FactorsABSTRACT
Eight cases (3 children aged 7-15 years and 5 adults aged 16-46 years) of hepatic abscess in whom a cure was obtained by medical therapy are presented. The abscess occurred during septicemia (2 cases), cutaneous staphylococcosis (2 cases) and pyocholecystitis (1 case). In 3 patients the abscess remained cryptogenic. The clinical diagnosis was confirmed by scintigraphy, ultrasonography and in one case by radiography with contrast substance in the abscess. The microorganisms, isolated in 3 patients from the abscess and in one patient from hemoculture, were S. aureus (3 cases) and gram negative bacilli (1 case). The systemic antibiotic therapy consisted in the administration of gentamicin and oxacillin or rifampicin in 4 cases and gentamicin and chloramphenicol or ampicillin and metronidazole in other 4 cases for an average interval of 39 days. The associated local therapy (3 cases) consisted in one or more punctures, followed by the injection of gentamicin.
