1.
Bioorg Med Chem Lett
; 17(4): 1078-81, 2007 Feb 15.
Article
in English
| MEDLINE
| ID: mdl-17127061
ABSTRACT
A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC(50) value as low as 0.022 and 0.065nM, respectively.
