The importance and the differences of bone morphogenetic proteins for osteoporotic hip fractures.

Bone morphogenetic proteins (BMPs), major contributors to tissue repair, have become one of the most exciting fields in rheumatic and orthopaedic research. In our study we aimed to evaluate the relationship between osteoporotic hip fractures and the serum levels of BMPs to reveal their potential roles in the diagnosis of patients. The study group included 62 patients with osteoporotic hip fracture (Group 1; intertrochanteric fracture, Group 2; collum femoris fracture) and the control group. All fractures were due to low energy trauma, simple falls. For all subjects BMD measurements were in agreement for osteoporosis and no significant differences were observed between the two fracture groups. Biochemical markers; BMP-4 and BMP-7 (pg/mL) were determined by commercial Elisa kits from the serum samples. The mean and standard error values of serum samples for BMP-4 and BMP-7 in Group 1 (100.70 +/- 10.03, 74.41 +/- 6.31 respectively) and in Group 2 (112.34 +/- 11.52, 81.91 +/- 10.14 respectively) were not statistically different however for both groups only BMP-7 values increased statistically when compared to the control group. BMP-7 measurements may not only serve as potential biochemical markers for determining disease severity but also the increased levels, an osteogenic factor and bone stimulating agent in vivo, after trauma elevated levels are adaptive or protective and therefore may reduce the severity of the fracture.

[Biomechanical comparison of two different wire stretching methods in the treatment of tibial plateau fractures with the Ilizarov echnique and the related clinical results]. / Tibia plato kiriklarinin Ilizarov teknigi ile tedavisinde iki degisik tel germe yönteminin biyomekanik karsilastirmasi ve klinik sonuçlari.

OBJECTIVES: In this study, the divergent wire stretching method used to fix the fractured pieces in the Ilizarov technique is biomechanically compared with the olive wire fixation method. PATIENTS AND METHODS: Between 1999 and 2005, 36 tibial plateau fractures of 34 patients (27 males, 7 females; mean age 48.4; range 26 to 81 years) were treated with the Ilizarov technique. Divergent wire stretching technique was used in all cases. Patients were mobilized regardless of fracture type and with full load bearing in the shortest possible time after the operation. In the second stage of this study, in order to achieve interfragmentary compression, the reciprocal olive wire method was compared with the divergent wire stretching method developed by us on tibia models at the biomechanic laboratory. RESULTS: All cases were mobilized with full weight bearing at the early postoperative period. The fusion period was 14 weeks and fixators were removed at an average of 19 weeks. No deep infection was observed in any of the cases. No other surgical intervention was required for nonunion or reduction failure. More than 2 mm separation was detected in 12 cases during 24 weeks of observation. But this has not been considered to be clinically significant. In 29 cases, the knee range of motion was 0-135 degrees. In the biomechanical phase of the study, no distinct difference was observed between the classic olive wire stretching method and the divergent wire stretching method regarding the preservation of the interfragmentary compression under weight. The divergent wire stretching method was significantly superior in achieving an homogeneous interfragmentary compression. CONCLUSION: The divergent wire stretching technique applied parallel to the Ilizarov fixation technique is an effective method for the early and unrestricted mobilization of the patients and the preservation of the range-of-motion of the joint.

The association of proximal femur geometry with hip fracture risk.

We aimed to discuss the risk assessments of patients with hip fractures due to the fall-related moderate or minimal trauma and compare them with non-fractured control patients by bone mineral density (BMD) and proximal femur geometric measurements to assess whether geometric measurements of femoral dimensions were associated with femoral strength and hip fracture risk. Forty-two osteoporotic patients with proximal femur fracture and 40 osteoporotic non-fractured age and gender-matched controls were included in the study. Lunar DXA was used for BMD measurements and proximal femur geometric measurements were performed manually on direct X-rays as hip axial length (HAL), femoral length (FL), and femoral neck width (FW). The trochanteric and total BMD values of the fracture group were significantly lower than the control group. There was a significant increase in FW/FL ratio in the fracture group that would be of specific importance for guidance: if FL values did not increase as did FW, it would point out a risk for fracture. The trochanteric BMD values were correlated with all increased measurements in the control group. There are genetically determined adaptive differences among individuals concerning bone morphology and bone mineral distribution. These different adaptations result in different bone strengths and fracture formation risk.