ABSTRACT
AIM: Recent evidence suggests that omentin-1, a visceral adipose-derived cytokine, may play a role in atherosclerosis The aim of this study was to evaluate whether serum omentin-1 levels are associated with peripheral artery disease (PAD) and its severity. METHODS: The present study was cross-sectional and observational. We enrolled 123 patients with PAD and 50 age-matched subjects without PAD. The cardiovascular risk factors, ankle-brachial index (ABI), and serum omentin-1 levels were assessed in all participants RESULTS: Patients with PAD had significantly lower omentin-1 levels than those without PAD (206. ±48.4 vs. 345. ±80 ng/mL, respectively; 0.001). A correlation analysis revealed positive correlations between the omentin-1 level and the ABI ( 0.52, P=0.008). After adjusting for cardiovascular risk factors, a decreased omentin-1 level was found to be an independent predictor of both PAD and its severity as measured by ABI in multivariate logistic regression analysis. CONCLUSION: The current study suggests a strong association between decreased serum omentin-1 levels and PAD and its severity. Thus, omentin-1 may be a novel biomarker for PAD.
Subject(s)
Cytokines/blood , Lectins/blood , Peripheral Arterial Disease/blood , Aged , Ankle Brachial Index , Biomarkers/blood , Case-Control Studies , Chi-Square Distribution , Cross-Sectional Studies , Down-Regulation , Female , GPI-Linked Proteins/blood , Humans , Logistic Models , Male , Middle Aged , Multivariate Analysis , Odds Ratio , Peripheral Arterial Disease/diagnosis , Peripheral Arterial Disease/etiology , Predictive Value of Tests , Risk Assessment , Risk Factors , Severity of Illness Index , TurkeySubject(s)
Femoral Vein/diagnostic imaging , Venous Thrombosis/diagnostic imaging , Adult , Anticoagulants/therapeutic use , Electrophysiology , Female , Heparin, Low-Molecular-Weight/therapeutic use , Humans , Male , Ultrasonography , Venous Thrombosis/etiology , Venous Thrombosis/prevention & controlABSTRACT
We describe a complication after radiofrequency (RF) ablation of a left free wall accessory pathway that resulted in acute occlusion of proximal left anterior descending (LAD) coronary artery in a 32-year-old male non-cocaine abuser. An interesting feature is the site of coronary artery occlusion which is remote from the RF application site. The RF energy applications were performed in the left lateral annulus remote from the LAD. The occlusion was successfully treated with placement of an intracoronary stent.
Subject(s)
Catheter Ablation/adverse effects , Coronary Thrombosis/etiology , Tachycardia, Supraventricular/surgery , Adult , Blood Vessel Prosthesis Implantation , Coronary Angiography , Coronary Thrombosis/diagnostic imaging , Coronary Thrombosis/surgery , Humans , Male , Stents , Tachycardia, Supraventricular/diagnostic imagingABSTRACT
The possibility of exercise-induced myocardial ischemia due to mitral valve prolapse (MVP) in the absence of coronary artery disease was evaluated with single-photon emission computed tomographic analysis using thallium-201 and technetium-99m sestamibi in 72 patients with MVP. Exercise electrocardiography was positive in 5 patients (8%), but single-photon emission computed tomography was found to be normal in all patients, and exercise-induced chest pain, electrocardiographic changes, and arrhythmias were found not to be related to myocardial ischemia in patients with MVP.
Subject(s)
Mitral Valve Prolapse/diagnostic imaging , Tomography, Emission-Computed, Single-Photon , Adult , Chest Pain/diagnosis , Chest Pain/etiology , Diagnosis, Differential , Dipyridamole/administration & dosage , Echocardiography , Electrocardiography , Exercise Test , Female , Humans , Injections, Intravenous , Male , Middle Aged , Myocardial Ischemia/diagnosis , Prospective Studies , Radiopharmaceuticals/administration & dosage , Reproducibility of Results , Technetium Tc 99m Sestamibi/administration & dosage , Vasodilator Agents/administration & dosageABSTRACT
Although arrhythmias are common in hypertrophic cardiomyopathy (HCM), complete atrioventricular (AV) block is very unusual. A 27-year-old female presented with a recent history of syncope and exercise intolerance. ECG demonstrated complete AV block. Two-dimensional Doppler echocardiography revealed HCM with a 60 mmHg left ventricular outflow tract (LVOT) gradient. A temporary transvenous ventricular pacemaker was inserted urgently, and subsequently replaced by a permanent DDD pacemaker. All symptoms were eliminated. This symptomatic improvement was associated with complete disappearance of LVOT gradient at the time of implantation. No gradient was observed during early follow-up and at 6 months after DDD pacemaker implantation.
