ABSTRACT
OBJECTIVE: The aim of this pilot study was to compare the efficacy of ALA-PDT and red light alone in the treatment of photoaging. METHODS: A total of 14 adults with photoaging skin were recruited. ALA-PDT or red light alone was applied to the forearm extensor. Before and after treatment, the treated sites were examined by dermoscopy, the changes in straum corneum (SC) hydration, transepidermal water loss (TEWL), and the L*a*b* values were measured, and microscopic examination of collagens and elastins was performed. RESULTS: After ALA-PDT or red light illumination, the appearance of photoaging lesions improved, SC hydration increased and TEWL decreased. These changes in the ALA-PDT group were more obvious than those in the red light group. No significant change was noticed in the L*a*b* values in both groups. The signs of typical solar elastosis damage were improved in both groups. CONCLUSIONS: ALA-PDT showed better skin rejuvenation effect than red light alone.
Subject(s)
Aminolevulinic Acid/therapeutic use , Photochemotherapy/methods , Rejuvenation/physiology , Skin Aging/drug effects , Skin Aging/radiation effects , Skin Physiological Phenomena/radiation effects , Skin/pathology , Adult , Color , Female , Humans , Male , Middle Aged , Photosensitizing Agents/therapeutic use , Phototherapy/methods , Pilot Projects , Skin/drug effects , Skin/radiation effects , Skin Physiological Phenomena/drug effects , Treatment OutcomeABSTRACT
Acne vulgaris is a common dermatological disorder. Topical photodynamic therapy (PDT)-mediated with aminolevulinic acid (ALA) or methyl aminolevulinic acid (MAL) has been successfully used in the treatment of moderate to severe acne. The purpose of this case report is to highlight the feasibility of using a repeat weekly short-cycle ALA-PDT to treat severe facial acne lesions refractory to systemic retinoid and antibiotics.
Subject(s)
Acne Vulgaris/drug therapy , Aminolevulinic Acid/administration & dosage , Facial Dermatoses/drug therapy , Photochemotherapy/methods , Chronic Disease , Humans , Male , Photosensitizing Agents/administration & dosage , Treatment Outcome , Young AdultABSTRACT
The present article investigated the laser induced breakdown spectra of atmosphere molecules as background spectrum for the measurement of airborne particles. The authors detailedly analyzed the spectral lines of oxygen, nitrogen and hydrogen in the laser induced breakdown spectra of atmosphere molecules corresponding to the National Institute of Standards and Technology atomic spectroscopy database line data. In addition, the authors studied the intensity of emitted spectral lines induced by laser breakdown process at different time delays and signal integration width As a result, the authors obtained the conclusion that the intensity of signal depends on variations of delay time strongly, and with a delay time more than 7 micros the interference resulting from the presence of atmosphere molecule can be reduced effectively in the application of laser induced breakdown spectroscopy. Also, the variations in signal integration width have few effects while it is longer than the instrument minimum of 1.1 ms. Besides, this paper investigated the relative intensities of spectral lines of oxygen, nitrogen and hydrogen in the condition of different contents of water vapor in atmosphere, and the authors observed that the intensities of atomic emission line of hydrogen have a linear trend varying with the moisture in atmosphere. These results can be useful for the further application of laser induced breakdown spectroscopy in detecting and monitoring of airborne particles in the air.