A multimodal Metal-Organic framework based on unsaturated metal site for enhancing antitumor cytotoxicity through Chemo-Photodynamic therapy.

Chemodynamic therapy when combined with chemotherapy opens up a new avenue for treatment of cancer. However, its development is still restricted by low targeting, high dose and toxic side effects. Herein, rational designing and construction of a new multifunctional platform with the core-shell structure 5-ALA@UiO-66-NH-FAM@CP1 (ALA = 5-aminolevulinic acid, CP1 = zirconium-pemetrexed (Zr-MTA)) has been performed. In this platform, CP1 acting as a shell is encapsulated with the UiO-66-NH2 to engender a core-shell structure that promotes and achieves a high MTA loading rate through high affinity between MTA and unsaturated Zr site of UiO-66-NH2. The 5-ALA and 5-carboxyl fluorescein (5-FAM) was successfully loaded and covalently combined with UiO-66-NH2 due to its high porosity and presence of amino groups. The characterization results indicated that the loading rate of MTA (41.03 wt%) of platform is higher than the reported values. More importantly, the in vitro and in vivo results also demonstrated that it has a good folate targeting ability and realizes high efficient antitumor activity by chemotherapy combied with photodynamic therapy (PDT). This newly developed multifunctional platform could provide a new idea for designing and constructing the carrier with chemotherapy and PDT therapy.

Applications of ROS-InducedZr-MOFs Platform in Multimodal Synergistic Therapy.

BACKGROUND: Metal-organic frameworks (MOFs) possess adjustable aperture, high load capacities, tailorable structures, and excellent biocompatibilities for their use as drug delivery carries in cancer therapy. Until now, Zr-MOFs, in particular, combine optimal stability towards hydrolysis and post synthetic modification with low toxicity, and are widely studied for their excellentbiological performance. INTRODUCTION: This review comprises the exploration of Zr-MOFs as drug delivery devices (DDSs) with a focus on various new methods, including chemotherapy (CT), photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), radiotherapy, immunotherapy, gene therapy and related combined therapies, which all generate reactive oxygen species (ROS) to achieve high efficiency of tumor therapy. CONCLUSION: We described and summarized these pertinent examples of the therapeutic mechanisms and highlighted the antitumor effects of their biological application both in vitro and in vivo. The perspectives on their future applications and the analogous challenge of the Zr-MOFs materials are given.

Self-adjusted bimetallic zeolitic-imidazolate framework-derived hierarchical magnetic carbon composites as efficient adsorbent for optimizing drug contaminant removal.

The construction of efficient and superior adsorbed materials for the precise removal of hazardous contaminants from water have gained significant attention by the scientific community. In this work, a facile bimetallic zeolitic-imidazolate framework (CoxZny-JUC-160) by using self-adjusted strategy (SAS) was developed to synthesize various N-doped Co-based hierarchical porous carbon composites through sacrificial template route. A series of highly porous magnetic materials with well-dispersed or reduced Co particle size have been fabricated by fine tuning the ratio of Co and Zn in the precursors. For the first time the effect of the Co/Zn ratio on the textural properties and drug adsorption performance of the resultant porous carbon composites have been investigated systematically. Remarkably, the optimal Co@NC-1/4-900 possesses large specific surface area, hierarchical pore structures, and well-distributed Co adsorption sites which facilitates the exposure of active Co center and realizes fast diffusion of amodiaquine (ADQ) molecules with record-high adsorption capacities (890.23 mg g-1). The presented synthetic strategy provides deep insights into the development of highly efficient recyclable magnetic adsorbent for the removal of contaminants.

Photocatalytic and Ferric Ion Sensing Properties of a New Three-Dimensional Metal-Organic Framework Based on Cuboctahedral Secondary Building Units.

A new three-dimensional microporous metal-organic framework based on Zn(II) clusters with the formula {[Zn7(NDC)5.5(µ4-OH)3]·7DMF} n (1) (H2NDC = 1,4-naphthalenedicarboxylic acid) had been synthesized and characterized. The MOF 1 displays an uncommon bsn topology, which is based on a unique heptanuclear Zn7(OH)3(CO2)11 cluster as a secondary building unit. The MOF had been employed as a photocatalyst for the photodegradation of model organic dyes rhodamine B and methyl violet in light. The results of photocatalytic experiments showed that 1 can successfully be employed as the photocatalyst for the benign decomposition of these dyes. A mechanism for the photcatalysis exhibited by 1 had been proposed using the results of density of states (DOS) and partial DOS calculations. The fluorescence properties of the MOF have been investigated, which revealed that 1 could be exploited as the luminescent sensor to recognize Fe3+ ions with perceptible quenching (K sv = 6.55 × 104 M-1) and a limit of detection of 1.16 ppm.

A red-emitting indolium fluorescence probe for membranes - flavonoids interactions.

The red-emitting indolium derivative compound (E)-2-(4-(diphenylamino)styryl)-1,3,3-trimethyl-3H-indol-1-ium iodide (H3) was demonstrated as a sensitive membrane fluorescence probe. The probe located at the interface of liposomes when mixed showed much fluorescence enhancement by inhibiting the twisted intramolecular charge transfer state. After ultrasonic treatment, it penetrated into lipid bilayers with the emissions leveling off and a rather large encapsulation efficiency (71.4%) in liposomes. The ζ-potential and particle size measurement confirmed that the charged indolium group was embedded deeply into lipid bilayers. The probe was then used to monitor the affinities of antioxidant flavonoids for membranes. It was verified that quercetin easily interacted with liposomes and dissociated the probe from the internal lipid within 60 s under the condition of simply mixing. The assessment of binding affinities of six flavonoids and the coincident results with their antioxidation activities indicated that it was a promising membrane probe for the study of drug bio-affinities.