ABSTRACT
Based on the panel data of 255 cities in China, this study built a spatial Durbin model to study the impact of China's industrialization on the PM2.5 pollution level. Meanwhile, an environmental governance tool characterized by forest and grass coverage was introduced to explore the internal mechanism and exogenous driving force of EKC. The results show that â the relationship between industrialization and PM2.5 concentration is obviously an inverted u-shaped, and the EKC hypothesis was verified. â¡ The formation of the EKC curve was caused by the external factors and not the endogenous mechanism of economic growth. Forest-grass coverage plays a regulating role in the relationship between industrialization and PM2.5 pollution level, namely the inverted u-shaped structure of environmental EKC results from environmental governance tool with forest and grass cover rather than the automatic adjustment of economic growth. ⢠The influence of industrialization on PM2.5 concentration has a spatial spillover effect. Urban industrialization not only affects the PM2.5 concentration in local regions but also its neighboring region.
ABSTRACT
Mounting evidence indicates that circular RNAs modulate the initiation of clear cell renal cell carcinoma (ccRCC). However, their specific roles in the malignancy of ccRCC is understudied. Here, we present a novel circular RNA, circDHX33, that is up-regulated in ccRCC cell lines and tissues. Upregulated circDHX33 in ccRCC patients significantly correlates with advanced TNM stage and metastasis. Suppressing circDHX33 expression inhibits the proliferation and invasion of cultured cells, and suppresses tumor growth in vivo. Mechanistically, we show that circDHX33 promotes ccRCC progression by sponging miR-489-3p and modulating MEK1 expression. In conclusion, our findings suggest that circDHX33 plays a role in promoting ccRCC via the miR-489-3p/MEK1 axis and may serve as a novel therapeutic target for the treatment of ccRCC patients.