1.
Chem Commun (Camb)
; 53(76): 10508-10511, 2017 Sep 21.
Article
in English
| MEDLINE
| ID: mdl-28868553
ABSTRACT
The well-characterized interaction between the MS2 coat protein and its cognate RNA hairpin was used to evaluate changes in affinity as a result of phosphorodithioate (PS2) replacing phosphate by biolayer interferometry (BLI). A structure-based analysis of the data provides insights into the origins of the enhanced affinity of RNA-protein interactions triggered by the PS2 moiety.