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1.
Mali Med ; 30(2): 15-18, 2015.
Article in French | MEDLINE | ID: mdl-29927140

ABSTRACT

In this study, we report the results of the experience of the Rheumatology Department of Cocody University Hospital in the management of the cervical spinal tuberculosis in Abidjan area. This was a retrospective study of 26 cases collected over a 7 year period (January 2006 to December 2013). The objective of this work was to illustrate the epidemiological, clinical and radiological profile of the cervical localization of tuberculosis in our practice. The prevalence of cervical disease was 4.87%. The average age of our patients was 48.27 years, with a slight male predominance (60.7%). The duration of disease progression was long (8 months on average); symptomatology was dominated by pain associated with stiffness in all patients (100%). One third of patients had already consulted at the stage of neurological complications (1 case of Brown Sequard syndrome, 2 cases of tetraparesis, 5 cases of paraplegia). Computer tomography was performed in all patients, followed by an MRI scan for 6 patients, which revealed the predominance of damage to the C3-C4 floor (34.62%) and 3 cases of sub occipital localization. Spondylodiscitis was the main radiological anatomical lesion (88.46%), lesions were multi-stage in 61.54% of cases, the prevalence of retropharyngeal abscess was high (84.61% of cases), that of the epiduritis was 76.92% and radiological spinal cord compression was recorded in a third of cases. All patients benefited from an antituberculous treatment associated with cervical immobilization.


Nous rapportons dans cette étude, les résultats de l'expérience du service de Rhumatologie du CHU de cocody dans la prise en charge du mal de pott cervical dans la région d'Abidjan. Il s'agissait d'une étude rétrospective de 26 cas colligés sur une période de 8 ans (janvier 2006 au décembre 2013). L'objectif de ce travail était d'illustrer les différents aspects épidémiologiques, cliniques et radiologiques de la localisation cervicale de la tuberculose dans notre pratique. La prévalence de l'atteinte cervicale était de 4,87% .L'âge moyen de nos patients était de 48,27 ans, avec une légère prédominance masculine (60,7%). La durée d'évolution de la maladie était longue (8 mois en moyenne); la symptomatologie était dominée par la douleur associée à une raideur chez tous nos patients (100%). Un tiers des patients consultait déjà au stade de complications neurologiques (1 cas de Syndrome de Brown Séquard, 2 cas de tétraparésie, 5 cas de paraplégie). La TDM a été réalisée chez tous nos patients, et complétée par l'IRM chez 6 patients, ce qui a permis de déceler la prédominance de l'atteinte à l'étage C3-C4 (34,62%) et une localisation sous occipitale dans 3 cas .La spondylodiscite était la principale lésion anatomo radiologique (88,46 %), Les lésions étaient pluri-étagées dans 61,54 % des cas, la prévalence des abcès retro pharyngiens était élevée (84,61 % des cas), une épidurite dans 76,92 %, et une compression médullaire radiologique dans un tiers des cas. Tous nos patients ont bénéficié d'un traitement antibacillaire associé à une immobilisation du foyer pottique.

2.
Sciences de la santé ; 1(2): 93-98, 2015.
Article in French | AIM (Africa) | ID: biblio-1271876

ABSTRACT

Objectif : Etudier les indications; l'efficacite et la tolerance des anti-inflammatoires non steroidiens chez les patients du service de rhumatologie du CHU de Cocody. Patients et methode. Etude retrospective de type descriptif menee dans le service de rhumatologie du CHU de Cocody (Abidjan) durant six ans allant de Janvier 2000 a Decembre 2005. Six cent deux dossiers de patients hospitalises pour une pathologie rhumatologique necessitant un traitement anti-inflammatoire non steroidien; ont ete inclus. Nous nous sommes interesses aux donnees demographiques; pharmacologiques; a l'efficacite et la tolerance des anti-inflammatoires non steroidiens. Resultats La prescription des anti-inflammatoires steroidiens a ete faite chez 24;02 des patients. Les femmes predominaient (55;9) avec un age moyen de 48;3 ans. La majorite des patients etait hospitalisee pour des lombalgies ou lomboradiculalagies (80;1). Les principales indications des anti-inflammatoires non steroidiens etaient les pathologies degeneratives rachidiennes (65;9) et les spondylarthropathies (11;6). Le ketoprophene appartenant a la famille des propioniques (80;6) a ete le plus prescrit (72). Les principaux effets indesirables etaient les epigastralgies (4;8); les vomissements (2;8) et les nausees (1;3). La duree moyenne de traitement etait de 13;4 jours. L'evolution etait satisfaisante dans 78;1 des cas. Conclusion : Les anti-inflammatoires non steroidiens sont beaucoup utilises en rhumatologie a Abidjan et le ketoprophene y est le plus prescrit. L'indication principale est la pathologie degenerative rachidienne. La prescription reste limitee par les effets secondaires dont la lutte passe par la limitation de la duree de traitement et la prevention de la toxicite digestive


Subject(s)
Academic Medical Centers , Anti-Inflammatory Agents, Non-Steroidal , Rheumatology
3.
Mali Med ; 29(3): 39-43, 2014.
Article in French | MEDLINE | ID: mdl-30049101

ABSTRACT

OBJECTIVE: Determine the prevalence and the main ocular manifestations in rheumatoid arthritis in Abidjan. PATIENTS AND METHODS: Prospective and descriptive study of 24 patients with rheumatoid arthritis fulfilling the criteria of the American College of Rheumatology, views from September 2003 to August 2004 in department of rheumatology at the University Hospital of Cocody. The patients performed an eye examination including: visual acuity examination at the slit lamp, ocular fundus, color vision and visual field. RESULTS: Ocular manifestations were observed in 9 of 24 patients representing a prevalence of 37.5%. There were 03 cases of decreased visual acuity, 03 cataract, 02 keratitis cases and 01 cases of anterior uveitis. No fundus abnormality in color vision and visual field was highlighted. These manifestations were found between 5 and 10 years (04 cases) and after 10 years (05 cases) of evolution of the disease. The term rheumatoid arthritis influenced the occurrence of ocular manifestations (P = 0.00). CONCLUSION: Ocular manifestations in rheumatoid arthritis are rare in our practice and were mainly affected by visual acuity, annexes and anterior segment of the eye.


OBJECTIF: Déterminer la prévalence et les principales manifestations oculaires au cours de la polyarthrite rhumatoïde à Abidjan. PATIENTS ET MÉTHODE: Etude prospective descriptive de 24 polyarthrites rhumatoïdes répondant aux critères de l'American College of Rheumatology, vues de Septembre 2003 à Août 2004 au service de rhumatologie du CHU de Cocody. Les patients ont effectué un examen ophtalmologique comprenant: acuité visuelle, examen à la lampe à fente, fond d'œil, vision des couleurs et champ visuel. RÉSULTATS: Les manifestations oculaires étaient observées chez 9 des 24 patients soit une prévalence de 37,5 %. Il s'agissait de 03 cas de baisse de l'acuité visuelle, 03 cas de cataracte, 02 cas de kératite et 01 cas d'uvéite antérieure. Aucune anomalie au fond d'œil, à la vision des couleurs et du champ n'a été mise en évidence. Ces manifestations ont été découvertes entre 5 et 10 ans (04 cas) et après 10 ans (05 cas) d'évolution de la maladie. La durée de la polyarthrite rhumatoïde influençait la survenue des manifestations oculaires (P=0,00). CONCLUSION: Les manifestations oculaires au cours de la polyarthrite rhumatoïde sont peu fréquentes dans notre pratique et étaient principalement des atteintes de l'acuité visuelle, des annexes et segment antérieur de l'œil.

4.
Mali Med ; 29(2): 72-74, 2014.
Article in French | MEDLINE | ID: mdl-30049131

ABSTRACT

We report three new cases of sub-occipital Pott disease (C1-C2) seen at the University Hospital of Cocody (Abidjan) with their clinical features. In the first case, the mode of revelation was original and unique: an incomplete Brown-Séquard syndrome. The second case provided warning about the dangers of self-medication and untimely antibiotic usage. The third case informed about the imperative to make the differential diagnosis. The histological or bacteriological arguments led to the diagnosis in the first two cases, associated with a visceral localization. Therapeutic evidence was required in the third case. The sub-occipital Pott's disease remains a rare localization.


Nous rapportons trois nouveaux cas de mal de Pott sous-occipital (C1-C2) vus au CHU de Cocody (Abidjan) avec leurs particularités cliniques. Dans le premier cas, le mode de révélation était original et unique: un syndrome de Brown-Séquard incomplet. Le second cas alerte sur le danger de l'automédication et de l'antibiothérapie intempestive. Le dernier cas instruit sur le caractère impératif de faire le diagnostic différentiel. Les arguments histologique ou bactériologique ont permis le diagnostic dans deux cas, associés à une localisation viscérale. La preuve thérapeutique a été nécessaire dans le dernier cas. Le mal de Pott sous-occipital demeure une localisation rare.

5.
Mali méd. (En ligne) ; 29(3): 33-35, 2014.
Article in French | AIM (Africa) | ID: biblio-1265680

ABSTRACT

Objectif : Determiner la prevalence et les principales manifestations oculaires au cours de la polyarthrite rhumatoide a Abidjan. Patients et Methode : Etude prospective descriptive de 24 polyarthrites rhumatoides repondant aux criteres de l'American College of Rheumatology; vues de Septembre 2003 a Aout 2004 au service de rhumatologie du CHU de Cocody. Les patients ont effectue un examen ophtalmologique comprenant: acuite visuelle; examen a la lampe a fente; fond d'oil; vision des couleurs et champ visuel. Resultats : Les manifestations oculaires etaient observees chez 9 des 24 patients soit une prevalence de 37;5 . Il s'agissait de 03 cas de baisse de l'acuite visuelle; 03 cas de cataracte; 02 cas de keratite et 01 cas d'uveite anterieure. Aucune anomalie au fond d'oil; a la vision des couleurs et du champ n'a ete mise en evidence. Ces manifestations ont ete decouvertes entre 5 et 10 ans (04 cas) et apres 10 ans (05 cas) d'evolution de la maladie. La duree de la polyarthrite rhumatoide influencait la survenue des manifestations oculaires (P=0;00). Conclusion : Les manifestations oculaires au cours de la polyarthrite rhumatoide sont peu frequentes dans notre pratique et etaient principalement des atteintes de l'acuite visuelle; des annexes et segment anterieur de l'oeil


Subject(s)
Arthritis, Rheumatoid , Eye Manifestations
6.
Sciences de la santé ; 1(1): 16-19, 2013.
Article in French | AIM (Africa) | ID: biblio-1271862

ABSTRACT

Objectif : Decrire les caracteristiques epidemiologiques; cliniques; radiologiques et therapeutiques des hernies discales lombaires vues en hospitalisation rhumatologique a Abidjan.Patients et methode : Etude retrospective descriptive sur 7 ans menee au service de Rhumatologie (unite d'hospitalisation) du CHU de Cocody portant sur 39 dossiers. Ont ete inclus tous les dossiers de patients ayant une hernie discale lombaire de diagnostic scannographique. Une fiche d'enquete a permis de recueillir les donnees epidemiologiques; cliniques; radiologiques et therapeutiques. Resultats : La frequence hospitaliere de la hernie discale lombaire etait de 4;1 par rapport a l'ensemble des pathologies lombaires (948 cas). Elle predominait chez l'adulte masculin (56;4) ages de 49 ans en moyenne. Les patients provenant du secteur informel (commercants; ouvriers; cultivateurs.) predominaient (30;8). Ils rapportaient des antecedents douloureux lombaires (82;1). La hernie discale lombaire se manifestait par une lombosciatalgie (82;1) hyperalgique de trajet monoradiculaire L5 (38;9) ou S1 (30;6). La radiographie standard montrait un pincement discal (56;4). Elle etait normale dans 15;4 des cas. La tomodensitometrie lombaire revelait la predominance des formes posteromedianes (30;8) et posterolaterales (25;6). La strategie therapeutique etait basee sur le traitement medicamenteux (89;7) et physique. La neurochirurgie etait indiquee dans 10;3 des cas. Conclusion : La hernie discale lombaire est peu frequente en hospitalisation rhumatologique a Abidjan. Elle s'exprime par un syndrome lomboradiculaire hyperalgique et est dominee par les formes postero-medianes et postero-laterales. Le traitement conservateur est le plus souvent indique. La lutte contre la baisse de productivite passe par la prevention par l'ecole du dos


Subject(s)
Intervertebral Disc Displacement , Intervertebral Disc Displacement/diagnosis , Intervertebral Disc Displacement/epidemiology , Intervertebral Disc Displacement/therapy , Tomography, X-Ray Computed
7.
Article in French | AIM (Africa) | ID: biblio-1260316

ABSTRACT

Consideres comme rares dans les pays en developpement; les cancers colorectaux sont de plus en plus frequents avec l'occidentalisation des habitudes alimentaires. Notre objectif a ete de decrire le profil epidemiologique et anatomopathologique de ces cancers dans deux CHU d'Abidjan en Cote d'Ivoire. Il s'agissait d'une etude retrospective realisee dans les laboratoires d'Anatomie pathologique de deux trois CHU d'Abidjan sur les cancers colorectaux histologiquement confirmes. La periode d'etude a ete de 24 ans (1984-2007). La frequence relative trouvee a ete de 3;34(394/11854) des cancers avec une predominance masculine (64). L'age moyen etait de 49 ans avec des extremes de 6 et 84 ans. Les polypes et les polyposes etaient les plus frequents des facteurs predisposants (41;66). L'ampoule rectale etait la zone la plus touchee (57; 82u). Les aspects vegetants; les adenocarcinomes et le stade pT2-T3 N1M0 ont constitues les aspects anatomopathologiques predominants. Ces cancers touchent ainsi des sujets jeunes avec pronostic souvent pejoratif


Subject(s)
Colorectal Neoplasms , Colorectal Neoplasms/epidemiology
8.
Morphologie ; 88(283): 196-201, 2004 Dec.
Article in French | MEDLINE | ID: mdl-15693424

ABSTRACT

The responsibility of the uteropelvic junction (UPJ) syndrome or abnormalities for renal affections and also for high obstructive uropathy is well-known. But, controversies still remain about the anatomic approach of this clinical feature. Our purpose is to elucidate the developmental anatomy of UPJ and eventually to set the steps of the anatomic approach of the UPJ abnormalities. This study also leads to a better understanding of the mechanism of the intrinsic ureteropelvic junction obstructions. A total number of 122 post-mortem specimens with ages ranging from 1 day to 30 months in both sexes underwent formalin treatment for histological investigation. We performed both transverse and longitudinal sections. Hematein-eosin-safran and Masson's trichrome staining were used. Histological examination revealed that myoarchitecture of UPJ set increasingly up. Circular muscle fibers were first to put in. They had an initial arrangement as a ring in neonates and infants. We conclude that circular layer appears first and sooner than others. On the other hand, coincidence in time between ages of our specimens and ages of patients sufferning from UPJ syndrome leads to further investigations to determine the implication of ring-shaped circular layer in intrinsic ureteropelvic junction obstruction.


Subject(s)
Kidney Pelvis/anatomy & histology , Ureter/anatomy & histology , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Kidney Pelvis/cytology , Kidney Pelvis/growth & development , Male , Ureter/chemistry , Ureter/growth & development
9.
Bull Soc Pathol Exot ; 94(1): 5-7, 2001 Mar.
Article in French | MEDLINE | ID: mdl-11346984

ABSTRACT

BACKGROUND: Helicobacter pylori (H. pylori) is the most frequent aetiological factor of chronic gastritis (CG). The relationship between H. pylori gastritis, gastro-duodenal ulcer and some gastric cancers (adenocarcinoma, gastric MALT lymphoma) has now been proven. AIM: Describe clinical, endoscopical and histological aspects of H. pylori gastritis in Côte d'Ivoire. METHODS: Retrospective analysis of 1960 gastroscopy reports carry out between January 1994 and December 1995. Analysis of clinical and gastric histological results in 137 patients. FINDINGS: Among 137 patients with gastric biopsy, 102 had H. pylori gastritis (68 men, 38 women, mean age: 39.3 years) and 35 had chemical gastritis. Epigastric pain was the most frequent symptom. The mucosa was frequently erythematous or exsudative at endoscopy. Histological anomalies were located in the antrum, the fundus or generalised, respectively in 33.3%, 25.5% and 41.2% of cases. Mild atrophic CG was more frequent in various locations. Gastritis activity was present in 81.4%, intestinal metaplasia in 18.6% and follicular lymphoid hyperplasia in 36.3% of cases. CONCLUSION: Clinical and endoscopical aspects of H. pylori gastritis did not present any particularities. Fundic gastritis without antral localisation was not unusual. This situation could be the result of antibiotic and gastric acid secretion inhibitor treatments.


Subject(s)
Gastritis/microbiology , Helicobacter Infections/pathology , Helicobacter pylori , Adult , Aged , Biopsy , Chronic Disease , Cote d'Ivoire , Female , Gastritis/diagnosis , Gastritis/pathology , Gastroscopy , Helicobacter Infections/diagnosis , Humans , Male , Middle Aged , Pain , Retrospective Studies
10.
Thesis in French | AIM (Africa) | ID: biblio-1276901

ABSTRACT

Le rocher ou pars petrosae est la partie petro-tympanique l'os temporal. II contient l'oreille Interne qui renferme les organes de l'audition et de l'equilibration. Dans le but d'apprecier la prevalence des tumeurs du rocher en Cote d'ivoire; de preciser leurs aspects en imagerie plus precisement au scanner; nous avons realise une etude retrospective a la Polyclinique Sainte Anne-Marie d'Abidjan; sur une periode de 10 annees (1989 a 1999). Les tumeurs du rocher sont tres rares en Cote d'ivoire; sur 23 dossiers de demande de scanner pour suspicion de tumeur du rocher; nous n'avons observe qu'un seul cas en 10 ans. Ce seul cas recense concernait une patiente de 37 ans et il s'agissait d'une tumeur de la pointe du rocher droit. Les tumeurs du rocher peuvent survenir a tout age avec un maximum de frequence a l'age adulte entre 45 et 52 ans et il semblerait qu'il n'existe pas de predominance de sexe. En revanche; les meningiomes semblent survenir de facon de facon preferentielle chez les femmes. L'examen tomodensitometrique (TDM) realisee sans injection de produit de contraste iode a mis en evidence chez notre patiente; une formation tumorale spontanement hyperdense; ovalaire; a bord net; mesurant 30 mm sur 23 mm et entouree d'une plage hypodense correspondant a de l'oedeme perilesionnel. Apres Injection de produit de contraste; un rehaussement souvent intense et homogene de la tumeur (90 pour cent des cas) est observe. Plus rarement; le rehaussement est heterogene. Malgre l'avenement de l'imagerie par Resonance Magnetique (IRM); le scanner reste un examen fiable pour le diagnostic des meningiomes puisqu'il permet le diagnostic positif de 95 a 100 pour cent des meningiomes. Dans tous les cas; le diagnostic de tumeur du rocher repose sur la conjonction des donnees cliniques radiologiques et anatomopathologiques


Subject(s)
Bone Neoplasms , Petrous Bone , Radiotherapy , Tomography, X-Ray Computed
11.
Thesis in French | AIM (Africa) | ID: biblio-1277092

ABSTRACT

Nous avons realise une etude retrospective qui s'est interessee aux toxicomanes recus au service d'Hygiene Mentale de I'INSP; dont la premiere consultation se situe entre le 1er janvier 1989 et le 31 decembre 1998. L'etude a permis de recenser 135 personnes et a permis de noter les caracteristiques suivantes : AU PLAN SOCIODEMOGRAPHIQUE : - une surrepresentation masculine : 88;1 pour cent contre 11;9 pour cent; une population essentiellement jeune : 90;4 pour cent est agee de moins de 35 ans ; - les desoeuvres sont les plus nombreux : 39 pour cent. AU PLAN DU SUIVI : - la demande de soin est le plus souvent a l'instigation d'autrui; - la duree du suivi est inferieure a trois mois dans 81;3 pour cent des cas dont 51;1 pour cent en un jour; - une forte proportion de non precisee pour certaines variables(circonstances de la prise : 64;4 pour cent; antecedent personnel: 81;5 pour cent ; antecedent familial : 90;4 pour cent ; insertion professionnelle: 67;4 pour cent ; reinsertion familiale : 79 pour cent ; motivation de la prise : 51;1 pour cent ; abstention declaree de prise de toxique(61 pour cent). Ces resultats montrant des insuffisances dans la prise en charge des toxicomanes doivent susciter une attention particuliere des autorites afin d'ameliorer les actions de prevention et de lutte contre la toxicomanie


Subject(s)
Substance-Related Disorders
12.
Cancer ; 89(3): 653-63, 2000 Aug 01.
Article in English | MEDLINE | ID: mdl-10931466

ABSTRACT

BACKGROUND: There are few data concerning cancer incidence rates in contemporary West Africa. The first data from the cancer registry of Abidjan, the capital of Ivory Coast, for the period 1995-1997 are reported in the current study. METHODS: The cancer registry attempts to record data on all new cases of cancer diagnosed in the city of Abidjan, including cases without histologic confirmation of diagnosis. RESULTS: Two thousand eight hundred fifteen new cancer cases were registered in 3 years, corresponding to age-standardized (world population) incidence rates of 83.7 per 100,000 in men and 98. 6 per 100,000 in women. As reported elsewhere in West Africa, the principal cancers in men were liver cancer (15%) and prostate cancer (15.8%), with modest rates of non-Hodgkin lymphoma (10.5%) and gastric cancer (4.5%). In women, breast cancer was the most frequent tumor (25.7%), followed by cervical cancer (24.0%) and non-Hodgkin lymphoma (7.3%). In contrast to other registry data from West Africa, Kaposi sarcoma occurs with moderate frequency (7.7% of cases reported in men and 2.1% in women). In the pediatric age group, relatively high incidence rates were found for Burkitt lymphoma. CONCLUSIONS: Although there most likely is some underascertainment of cases, so that the actual incidence rates may be underestimated, the cancer profile should be a fair reflection of the true situation. In addition to tumors that are well known to be common in sub-Saharan Africa, such as cancers of the liver and cervix, this urban population shows some features of "Westernization" of cancer patterns, in particular the relatively high rates of breast cancer and prostate cancer. The effects of the acquired immunodeficiency syndrome epidemic are reflected in the moderate rates of Kaposi sarcoma reported.


Subject(s)
Neoplasms/epidemiology , Adolescent , Adult , Aged , Child , Child, Preschool , Cote d'Ivoire/epidemiology , Female , Humans , Incidence , Infant , Male , Middle Aged , Registries
13.
Clin Exp Pathol ; 47(2): 92-5, 1999.
Article in French | MEDLINE | ID: mdl-10398581

ABSTRACT

Malignant melanomas (MM) are rare tumors of very bad prognosis. Few studies have precised the anatomopathological aspects and prognosis of these tumors in Africa and especially in Côte d'Ivoire. This has prompted us to review 195 cases of MM diagnosed in our laboratories in order to precise their epidemiological and anatomical features. Biopsies and/or surgical specimens fixed in 10% buffered formalin have been studied using the paraffin embedding methods and staining with hematoxylin and eosin, Masson's trichrome and Fontana. 117 men (60%) and 78 women (40%) with a medium age of 57 years were studied. Cutaneous MM were predominant (174 cases, 93%) with 57.8% located on the foot. Non classified (38.2%) and nodular (33.6%) forms were more frequent with only 19% of acral lentiginous melanomas. The prognosis of our cases was poor with 71% of levels IV or V according to Clark and Mihm, Breslow's thickness superior to 3 mm in 93% of cases and ulceration in 91.3%. Our study emphasizes the poor prognosis of MM in Côte d'Ivoire. These tumors are frequent in the elderly and located predominantly on the foot.


Subject(s)
Melanoma/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , Cote d'Ivoire/epidemiology , Female , Humans , Male , Melanoma/pathology , Middle Aged , Prognosis
14.
Cancer ; 82(12): 2401-8, 1998 Jun 15.
Article in English | MEDLINE | ID: mdl-9635533

ABSTRACT

BACKGROUND: Squamous intraepithelial lesions (SILs) of the cervix are associated with human immunodeficiency virus (HIV) infection, but multiple risk factors must be considered in this context. The authors performed a cross-sectional study to assess the prevalence of and the factors associated with SILs and invasive cervical carcinoma (ICC). METHODS: In Abidjan, Côte d'Ivoire, women were recruited from three outpatient gynecology clinics and screened for both cervical disease and HIV infection. A CD4 cell count was performed for HIV-infected women. RESULTS: A total of 2198 women were included in the study. The prevalence of HIV infection was 21.7%. Of the 2170 women who underwent a cervical screening, 254 (11.7%) presented with a dysplasia or neoplasia: 7.6% had low grade SILs (LSILs), 3.3% had high grade SILs (HSILs), and 0.8% had ICCs. In multivariate analyses, factors associated with these lesions were as follows: for LSILs, HIV-1 seropositivity, age <24 years, parity >1, consultation for genital infection, and no use of oral contraception in the past; for HSILs, HIV-1 seropositivity, chewing tobacco use, low educational level, and parity >1; and for ICCs, age >33 years, parity >3, and illiteracy. In women infected with HIV-1, the prevalence of LSILs increased with a decrease in CD4 cell count, whereas this relation was not found among patients with HSILs. ICCs were linked to HIV-2 infection, but not to HIV-1 infection, in univariate analysis. CONCLUSIONS: In Africa, the prevalence of SILs is high. The factors associated with precancerous and cancerous lesions are different. Cancers in women infected with HIV-1 often may not reach the invasive stage. These findings could have implications for cervical screening programs in the future.


Subject(s)
Carcinoma in Situ/epidemiology , Carcinoma, Squamous Cell/epidemiology , HIV Infections/complications , HIV-1 , Immunocompromised Host , Uterine Cervical Diseases/complications , Uterine Cervical Neoplasms/epidemiology , Adult , Carcinoma in Situ/etiology , Carcinoma, Squamous Cell/etiology , Cote d'Ivoire/epidemiology , Cross-Sectional Studies , Female , Humans , Mass Screening , Middle Aged , Prevalence , Risk Factors , Uterine Cervical Diseases/epidemiology , Uterine Cervical Neoplasms/etiology
15.
East Afr Med J ; 73(5 Suppl): S29-30, 1996 May.
Article in English | MEDLINE | ID: mdl-8756025

ABSTRACT

PIP: During a 9-month period in 1991, an autopsy was conducted on 247 cadavers of HIV-positive adult patients who died in a hospital in Abidjan, Ivory Coast. The most common cause of death among adults in Abidjan is AIDS. During 8 months in 1991-92, an autopsy was also conducted on 78 HIV-positive cadavers of children 2 months to 8 years old and on 78 HIV-negative cadavers of children 2 months to 12 years old located in a morgue in Abidjan. The pathologists aimed to determine the incidence of lymphoma among HIV-infected adults and children. Seven (2.8%) adult cadavers had B-cell lymphoma, each having been diagnosed with it in the postmortem. The types were visceral (4) and primary cerebral (3) lymphomas. The researchers estimated the non-Hodgkin's lymphoma crude incidence rate among adults in Abidjan to be 84/100,000 per year. This incidence is 10 times greater than expected among HIV-negative people. With 11% HIV prevalence, the incidence of non-Hodgkin's lymphoma is expected to double. None of the HIV-positive cadavers of children had B-cell lymphoma. Two HIV-negative children (ages 5 and 9) had B-cell lymphoma of Burkitt and lymphoblastic type lymphoma, respectively. In both child cases, the viscera was involved.^ieng


Subject(s)
HIV-1 , HIV-2 , Lymphoma, AIDS-Related/virology , Adolescent , Adult , Biopsy , Cause of Death , Child , Child, Preschool , Cote d'Ivoire/epidemiology , Female , Humans , Incidence , Infant , Lymphoma, AIDS-Related/epidemiology , Lymphoma, AIDS-Related/pathology , Male , Middle Aged
16.
Med. Afr. noire (En ligne) ; 42(3): 165-166, 1995.
Article in French | AIM (Africa) | ID: biblio-1266016

ABSTRACT

La cytologie urinaire est un examen non invasif; utile dans le diagnostic et dans la surveillance des tumeurs des voies extra-urinaires notamment vesicales. Cette etude retrospective a porte sur 151 prelevements d'urine provenant exclusivement du service d'Urologie du CHU de Cocody et adresses au Laboratoire de Cytologie de la Faculte de Medecine de 1980 a 1990. 20 dossiers (13;2 pour cent) ont ete retenus sur un seul critere: la presence de cellules malignes ou suspectes dans le prelevement urinaire. Au plan epidemiologique; les 20 malades etaient tous des adultes; dont la moyenne d'age etait de 52;8 ans. Le sexe masculin etait predominant (85 pour cent). La symptomatologie dominee par l'hematurie (100 pour cent) etait souvent associee a des lombalgies; une pollakiurie et/ou une dysurie (14 cas sur 20). Des oeufs de bilharzies n'ont pas ete retrouves. Au plan clinique; les diagnostics les plus souvent evoques etaient: les tumeurs vesicales (60 pour cent) et les tumeurs prostatiques avec extension vesicale (20 pour cent). Au plan cytologique; parmi les 20 prelevements retenus; 13 etaient des carcinomes evidents (carcinomes epidermoides vesicaux) et 7 ont paru suspects. L'examen histologique realise dans 7 cas (35 pour cent); a permis de confirmer 5 diagnostics cytologiques (71;42 pour cent) et de deceler 2 faux negatifs (28;57 pour cent). Les correlations cytoclinique: 91 pour cent et cyto-histologique: 71;4 pour cent etaient satisfaisantes pour les cancers vesicaux dans cette etude et ont permis aux auteurs de conclure que l'examen cytologique des urines dans la pathologie tumorale vesicale; demeure un moyen d'investigation fiable et sensible. Il apparait cependant important de sensibiliser les medecins et les auxiliaires de la sante; au bon conditionnement des prelevements afin d'eviter les problemes d'interpretation lies aux alterations cellulaires


Subject(s)
Urinary Bladder Neoplasms/diagnosis , Urine/cytology
17.
Int J Cancer ; 59(1): 20-4, 1994 Oct 01.
Article in English | MEDLINE | ID: mdl-7927898

ABSTRACT

HIV infection predisposes to the development of non-Hodgkin lymphoma (NHL). The frequency of NHL among HIV-positive adults and children in sub-Saharan Africa is not known. In 1991-1992, a representative autopsy study of HIV infection was performed in Abidjan, Côte d'Ivoire. Of 247 HIV-positive adult (> 14 years) medical patients dying in hospital, 2.8% had NHL, 1.6% with visceral NHL and 1.2% with primary cerebral lymphoma. The estimated crude incidence of NHL among HIV-positive adults in Abidjan was 84/100,000 per year, 10-fold greater than the expected pre-AIDS incidence of NHL but less than the incidence observed among HIV-positive adults in industrialised countries. None of 78 autopsied HIV-positive children (median age = 17 months) had NHL. HIV infection augments the incidence of NHL among adults in Africa, but short survival with advanced HIV disease probably prevents the major increase in HIV-associated NHL seen in industrialised countries. Survival of HIV-positive children in Africa appears too short to permit the significant development of additional NHL; classic Burkitt lymphoma is not an AIDS-associated tumour in Africa.


Subject(s)
Lymphoma, AIDS-Related/epidemiology , Adolescent , Adult , Autopsy , Child , Child, Preschool , Cote d'Ivoire , Female , HIV Seropositivity , Humans , Infant , Lymphoma, AIDS-Related/pathology , Male
18.
BMJ ; 308(6943): 1531-3, 1994 Jun 11.
Article in English | MEDLINE | ID: mdl-7912597

ABSTRACT

OBJECTIVES: To assess the contribution of tuberculosis to the aetiology of the HIV wasting syndrome (slim) in Africa, a condition usually considered an enteropathy. METHODS: Clinical examination and representative necropsy study of adult patients positive for HIV. SETTING: Hospital medical wards in Abidjan, Ivory Coast. SUBJECTS: Adults positive for HIV. MAIN OUTCOME MEASURES: CD4 T lymphocyte counts before death, clinical and anthropometric data, and gross and microscopic pathology. RESULTS: Necropsy was done on 212 HIV positive adults. Tuberculosis was found in 41 of 93 with the clinical HIV wasting syndrome and in 32 of 119 without (odds ratio 2.1, 95% confidence interval 1.2 to 4.0). A significant association existed between the prevalence of tuberculosis at necropsy and the degree of cadaveric wasting (no wasting 25% (15/59); moderate wasting 40% (23/58); skeletal wasting 44% (42/95); P = 0.02). Wasting was also associated with a history of chronic diarrhoea, but no association existed between diarrhoea and tuberculosis. Median CD4 T lymphocyte counts were lowest in wasted patients irrespective of findings at necropsy and in those with chronic diarrhoea (< 60 x 10(6)/l). CONCLUSION: Wasting and chronic diarrhoea are late stage manifestations of HIV disease in Africa. The importance of tuberculosis as a contributing factor in the pathogenesis of the slim syndrome has been underestimated. In nearly half of patients dying with severe wasting, tuberculosis was the dominant pathological finding.


PIP: The authors explore the contribution of tuberculosis (TB) to the etiology of HIV wasting syndrome in Africa, usually considered to be an enteropathy. Clinical examinations and necropsy were performed upon 212 HIV positive adults in the medical wards of the largest hospital in Abidjan, Cote d'Ivoire. TB was found in 41 of 93 patients with the clinical wasting syndrome and in 32 of 119 without. Significant associations were found between the prevalence of TB at necropsy and the degree of cadaveric wasting, moderate wasting, and skeletal wasting. Wasting was also associated with a history of chronic diarrhea, but no association existed between diarrhea and TB. Median CD4 counts were lowest in wasted patients irrespective of findings at necropsy and in those with chronic diarrhea. The authors note that wasting and chronic diarrhea are late stage manifestations of HIV disease in Africa and argue that researchers and practitioners have underestimated the importance of TB as a contributing factor in the pathogenesis of slim disease.


Subject(s)
CD4-Positive T-Lymphocytes/immunology , Emaciation/immunology , HIV Infections/immunology , Tuberculosis/immunology , Adolescent , Adult , Autopsy , Chronic Disease , Diarrhea/etiology , Diarrhea/immunology , Emaciation/etiology , Female , HIV Infections/complications , Humans , Leukocyte Count , Male , Syndrome , Tuberculosis/complications , Tuberculosis/pathology
19.
Rev Pneumol Clin ; 50(3): 116-20, 1994.
Article in French | MEDLINE | ID: mdl-7724970

ABSTRACT

Autopsies were performed in the Pathology Department of the Treichville University Hospital, Abidjan, Ivory Coast in 70 HIV infected subjects who had died in the Department of Pneumophtisiology. The prevalence of Pneumocystis carinii pneumonia was determined. None of the patients had received prophylaxis against P. carinii and none had bee treated for pneumocystosis. Autopsies were performed within 6 to 48 hours after death and the diagnosis of pneumocystosis was confirmed with the Gomori-Grocott staining technique on lung specimens. Among the 70 autopsies Pneumocystis carinii pneumonia was observed in 6. Thus the prevalence of P. carinii pneumonia in these patients infected with HIV was 8.57%.


Subject(s)
AIDS-Related Opportunistic Infections/epidemiology , HIV Infections/complications , Pneumocystis Infections/epidemiology , AIDS-Related Opportunistic Infections/diagnosis , AIDS-Related Opportunistic Infections/pathology , Adult , Autopsy , Cote d'Ivoire/epidemiology , Female , HIV Infections/pathology , Humans , Male , Middle Aged , Pneumocystis Infections/etiology , Pneumocystis Infections/pathology , Prevalence , Tuberculin Test , Tuberculosis/diagnosis , Tuberculosis/epidemiology
20.
Arch Anat Cytol Pathol ; 42(6): 328-9, 1994.
Article in French | MEDLINE | ID: mdl-7748007

ABSTRACT

We have observed one case of adenomyoepithelioma of the breast in a 65-years-old woman. Mammography was suspicious of malignancy. Morphological features were characteristic of this tumor. The origin of tumor cells was defined by immunohistochemical study using keratin and actin. The follow-up is not sufficient to predict the prognosis of our case.


Subject(s)
Adenomyoma/pathology , Breast Neoplasms/pathology , Carcinoma/pathology , Adenomyoma/surgery , Aged , Breast Neoplasms/surgery , Carcinoma/surgery , Female , Humans , Immunohistochemistry , Mastectomy
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