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1.
Transplant Proc ; 51(7): 2346-2349, 2019 Sep.
Article in English | MEDLINE | ID: mdl-31358452

ABSTRACT

INTRODUCTION: Recipients of kidney transplants are a very heterogeneous population and the risk of posttransplantation complications markedly varies according to the recipient's status. Scoring systems that predict survival outcome after kidney transplantation can help physicians improve risk stratification among recipients and make the best therapeutic decisions. This study aimed to assess the 1-year risk of major adverse events in potential recipients of kidney transplant at Saint-Louis University Hospital. MATERIAL AND METHODS: We performed a cross-sectional study including 65 patients with end-stage renal disease who were treated in the hemodialysis unit at Saint-Louis University Hospital. Scoring was based on a simple clinical tool with 4 items (age, cardiopulmonary factors, functional status, and metabolic parameters) reported to predict risk of severe adverse events during the first posttransplant year. RESULTS: The mean age of patients in years ± SD was 46.9 ± 23.5 and 53% were male. Median dialysis duration was 29.9 months and the main causes of kidney disease were hypertension and diabetes. A history of coronary artery disease was present in 22.3% of patients, and 33.5% had a high cardiovascular risk. According to the clinical score, 63.8% of potential recipients of kidney transplant presented a high risk of adverse events and 12.5% had a low risk of developing major complications during their first year posttransplantation. CONCLUSIONS: This study shows that based on a simple pretransplant clinical assessment, two-thirds of our patients are at high risk for major adverse events during their first posttransplantation year. Such information could be invaluable during the counseling of donor and recipient couples.


Subject(s)
Kidney Transplantation/adverse effects , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Adult , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Risk Factors , Senegal , Tissue Donors
2.
Article in French | AIM (Africa) | ID: biblio-1269338

ABSTRACT

Introduction : L'hyperparathyroïdie primaire(HPTp) apparaît rare en Afrique.Nous en rapportonobservations.Matériels et méthodes : Etude rétrospective réalisée dans le service de Rhumatologie du CHU Aristide Le Dantec de Dakar, où avaient été colligées les observations d'HPTp entre janvier 2000 et juin 2017. Le diagnostic avait été établi sur l'association d'une hypercalcémie permanente et une augmentation sérique de la PTH 1-84 dosée par immunoassay.Résultats : Vingt-deux observations ont été colligées chez 18 femmes et 4 hommes, d'âge moyen de 51,35 ans. Les affections associées étaient 2 cas de NEM de type II et des pathologies systémiques chez 8 patients. La maladie était de découverte systématique chez 12 patients (54,5%des cas). Le bilan phosphocalcique objectivait en moyenne une hypercalcémie à 117,70 mg/l,une hypophosphatémie à 30,04 mg/l, une hypercalciurie des 24heures à 244 mg et une hyperphosphaturie des 24 h à 342,7 mg. La PTH 1-84 sérique était augmentée avec un taux moyen de 248,21 ng/l. Les lésions étaient une hyperplasie dans 3 cas et un adénome dans 19 cas. Le traitement chirurgical avait été effectué chez 12 patients (54,5%). L'évolution fût favorable sauf chez 2 patients décédés de co-morbidités.Conclusion : Nous insistons sur la systématisation du dosage de la calcémie notamment chez toute femme âgée de plus de 50 ans, pour un dépistage précoce au stade asymptomatique de l' HPTp


Subject(s)
Africa , Hyperparathyroidism, Primary , Senegal
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