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1.
Arch Pediatr ; 23(5): 514-8, 2016 May.
Article in French | MEDLINE | ID: mdl-27017359

ABSTRACT

Malignant infantile osteopetrosis is a rare genetic disease characterized by increased bone density due to osteoclastic dysfunction. We report on the case of a 3-month-old girl who was referred to our hospital by the ENT department for severe anemia in the context of bilateral choanal atresia. Clinical examination showed failure to thrive, anemia, respiratory distress, bilateral choanal atresia, and chest deformation. The abdomen was soft with large hepatosplenomegaly. We noted a lack of eye tracking, no optical-visual reflexes, and left nerve facial paralysis. The blood count showed normocytic normochromic anemia with severe thrombocytopenia. The infectious work-up and blood smears were negative. The skeleton X-ray showed diffuse bone densification of the skull, long bones, pelvis, vertebrae, and ribs. The facial bone CT confirmed membranous choanal atresia. The molecular biology search for the TCIRG1 gene mutation was not available. The patient had supportive treatment (transfusion, oral steroid, vitamin D, oxygen, nutrition). Bone marrow transplantation was indicated but not available. She died at 6 months in a context of severe anemia and bleeding. Malignant infantile osteopetrosis is rare and symptoms are nonspecific. Diagnosis should be considered in young infants presenting refractory anemia, particularly in the context of choanal atresia. Bone marrow transplantation remains the only curative treatment.


Subject(s)
Choanal Atresia/diagnosis , Choanal Atresia/etiology , Osteopetrosis/complications , Osteopetrosis/diagnosis , Anemia/etiology , Anemia/therapy , Blood Transfusion/methods , Bone Density Conservation Agents , Facial Paralysis/etiology , Fatal Outcome , Female , Glucocorticoids/therapeutic use , Hemorrhage/etiology , Hepatomegaly/etiology , Humans , Hyperbaric Oxygenation/methods , Infant , Osteopetrosis/genetics , Osteopetrosis/therapy , Splenomegaly/etiology , Thrombocytopenia/etiology , Thrombocytopenia/therapy , Vitamin D/therapeutic use
2.
Arch Pediatr ; 23(5): 491-6, 2016 May.
Article in French | MEDLINE | ID: mdl-27021881

ABSTRACT

UNLABELLED: Liver abscess is a serious infection that can cause life-threatening complications. OBJECTIVE: To describe the epidemiology, diagnosis, and progression of liver abscess at the Dakar National Albert-Royer Children's Hospital. METHOD: A retrospective study was conducted from over a period of 5 years (1st January 2010 to 31st December 2014). All children aged 0-15 years hospitalized for liver abscess with ultrasound confirmation were included. We collected demographic data (age, gender, socioeconomic status, origin), clinical data (general and hepatic symptoms), diagnostic data (ultrasound, bacteriology) and progression (death, complications, sequelae). The data were analyzed with Epi-info (P<0.05 was considered significant). RESULTS: We collected 26 cases of liver abscesses, representing a hospital prevalence of 100 cases per 100,000 admissions. Males predominated (sex ratio: 1.36). The children's average age was 7.2 years. Most of the children came from urban areas of Dakar. Low socioeconomic status and precarious lifestyle were the contributing factors. Anemia (69.2%), malnutrition (42.3%), and abdominal trauma (15.3%) were the main causes found. The Fontan triad characteristic of the liver abscess was found in 57.7% of cases. At ultrasound, a single abscess was found in 21 cases. The abscess was located in the right lobe in 18 cases, the left lobe in three cases, and in both lobes in three cases. Segment VI (four cases) was the most frequently involved. Bacteriologically, the abscess was pyogenic in 17 cases and an amoebic abscess in nine cases. The main pyogenic sources found were Klebsiella pneumoniae in two cases, Pseudomonas aeruginosa in one case, Streptococcus pneumoniae in one case, and Staphylococcus aureus in one case. The average duration of antibiotic treatment was 14.5 days. Liver drainage was carried out in 24 cases. The outcome was favorable in all children. CONCLUSION: The prevalence of liver abscesses at the Albert-Royer Children's Hospital is relatively high, compared to the literature data. Percutaneous drainage combined with antibiotics remains the treatment of choice. The prognosis is favorable.


Subject(s)
Bacterial Infections/complications , Bacterial Infections/epidemiology , Liver Abscess, Amebic/epidemiology , Liver Abscess, Pyogenic/epidemiology , Liver Abscess, Pyogenic/microbiology , Rural Population/statistics & numerical data , Urban Population/statistics & numerical data , Adolescent , Anti-Bacterial Agents/therapeutic use , Bacterial Infections/diagnosis , Bacterial Infections/therapy , Child , Child, Preschool , Entamoeba histolytica/parasitology , Female , Hospitals, Pediatric , Humans , Infant , Klebsiella pneumoniae/isolation & purification , Life Style , Liver Abscess, Amebic/complications , Liver Abscess, Amebic/diagnosis , Liver Abscess, Amebic/therapy , Liver Abscess, Pyogenic/diagnosis , Liver Abscess, Pyogenic/therapy , Male , Poverty , Prevalence , Pseudomonas aeruginosa/isolation & purification , Retrospective Studies , Risk Factors , Senegal/epidemiology , Staphylococcus aureus/isolation & purification , Streptococcus pneumoniae/isolation & purification , Suction , Treatment Outcome
3.
Med Mal Infect ; 45(11-12): 463-9, 2015.
Article in English | MEDLINE | ID: mdl-26584841

ABSTRACT

OBJECTIVES: We aimed to describe the clinical, epidemiological, and outcome characteristics of IPD case patients hospitalized at the Albert-Royer National Children's Hospital (French acronym CHNEAR) to evaluate the disease burden of IPDs in a pediatric hospital of Dakar (Senegal). PATIENTS AND METHODS: All children aged 0-15 years hospitalized at the CHNEAR between January 1st, 2008 and December 31st, 2013 for a documented IPD were included in the study. Medical history, risk factors, clinical, bacteriological, and outcome data was collected. Data was then analyzed using the SPSS software, version 16 (Pearson's Chi(2) test: a P-value<0.05 was considered statistically significant). RESULTS: A total of 218 IPD patients were hospitalized at the CHNEAR during the study period (hospital prevalence: 0.79%). The mean age was 36.1 months. The male to female ratio was 1.27 (122 boys and 96 girls). Infants<2 years of age represented 61.46% of patients. Prior antibiotic therapy was found in 54% of patients but details were lacking. Infection sites were mostly meningeal (61%) and pleuropulmonary (28.9%). The main isolated serotypes were 1, 6A, 14, 5, and 23F. Case fatality was 17.4% and it was five times higher for pneumococcal meningitis. CONCLUSION: IPDs are very common in children in Senegal. Infants<2 years of age are particularly affected. The very high case fatality (17%) was significantly associated with meningeal infection sites hence the need for better access to pneumococcal vaccines.


Subject(s)
Pneumococcal Infections , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , Pneumococcal Infections/diagnosis , Pneumococcal Infections/epidemiology , Pneumococcal Infections/microbiology , Retrospective Studies , Senegal/epidemiology
4.
Dakar Med ; 47(2): 159-63, 2002.
Article in French | MEDLINE | ID: mdl-15776667

ABSTRACT

In Senegal, governmental fight plan against malaria emphasizes the need to community actions, particularly for early treatment of child malaria at home. So, we carried out a cross sectional survey, to determine factors linked with treatment of child malaria at home. During February 2001, we had an interview with persons taking care of a child under five years. These persons were randomly chosen among population of a rural town. Their median age was 32 years, 90.5% of them were women, 77.8% were the mother of the child. Their level of knowledge about malaria was fair (hightest transmission period, promoting environmental factors); 85.1% quoted children as vulnerable group; for 85%, fever was chief sign of malaria. When the child had fever, 45% of them brought him to a health center and 44% gave him chloroquin; 67.5% related no harmful effects. But at the time of the survey, only 28.8% had chloroquin at home. Literacy was very linked with home care: literate persons knowed most frequently the way of transmission by mosquito bites (72.4% versus 52.9% p<10-4 OR=2.3[1.5-3.6]); they considered most frequently chloroquin as the malaria treatment (74% versus 60.1% p=.003 OR=1.8 [1.2-2.9]) ;they had more often chloroquin at home (35.4% versus 22.6% p=.004 OR=1.8 [1.1-2.9). In conclusion, chloroquin might be available at home. The high ratio of illiterate persons in the population taking care of children in Mekhe emphasizes the need to organize information, education and communication strategies, using persons coming from the same community. The real impact of literacy on knowledges, behaviours and practices of persons taking care of malarial child at home emphasizes the need of reinforcing it, especially for women.


Subject(s)
Antimalarials/therapeutic use , Chloroquine/therapeutic use , Malaria/drug therapy , Adolescent , Adult , Aged , Aged, 80 and over , Child, Preschool , Community Health Services , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Rural Population , Senegal , Socioeconomic Factors , Surveys and Questionnaires
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