Progression of Disease in COVID-19 Patients Evaluated by Chest CT Imgaing and Correlated with Clinical Parameters.

The objective of the study was to investigate and quantify the severity of COVID-19 infection by high resolution computed tomography (CT) of chest and to determine its relationship with clinical parameters. This study also aimed to see CT changes with clinical recovery or progression of disease. This cross sectional study was performed from July 20 to August 20, 2020, where both chest HRCT and clinical features were included in laboratory confirmed COVID-19, 100 patients, attending the depertment of Radiology & Imaging, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. This study included clinical symptoms, comorbidities of patients, HRCT chest characteristics, CT severity score. After collection of all required data and careful medical chest review, the clinical data of laboratory confirmed patients was compiled and tabulated. In this study group out of 100 patients, most of the patients were in 5th & 6th dacades with a mean age of 53.7 years. In this study out of 100 patients 72% were male and 28% were female with an average sex ratio of male : female being 2.5:1. Prevalance of various clinical presentation in this study sample population distributed as fever in 76% cough in 77.4%, shortness of breath in 55%, sore throat in 17% were the most common clinical manifestations while a few patients (13.2%) also had other symptoms like headache, chest tightnes, anosmia and diarrhoea. Major comorbid conditions were diabets mellitus, hypertension, bronchial asthma and Chronic kidney disease (CKD). Patient with comorbid disease, especially if multiple had higher symptomatic presentation. Out of 100 patients 75.5% patient had co-morbidity where as 24.5% ptaients did not have any co-existing disease. According to HRCT imaging severity score the lung pathological changes were evaluated, when typical covid findings in 80%, intermediate in 10%, atypical in 2% and normal chest CT findings in 8% patients. Symptomatic presentation had found higher (85.21%) who had CT severity index >15/25 while sympotomatic presentation lesser (14.79%) who had CT severity index <15/25. CT severity index of 1-5 was seen in 20(21.73%) patients, 6-10 in 38(41.30%) patients, 11-15 in 22(23.91% patients, 16-20 in 10(10.86%) patients and 21-25 in 2(2.17%). As positive CT findings were more prominent in symptomatic and co-morbid patients HRCT chest in COVID-19 patient had a major diagnostic and prognostic importance. Clinical symptoms of patients directly correlated with CT severity score. Therefore, CT imaging was found to be useful in predicting clinical recovery of patient or progression of disease.

Evaluation of Diagnostic Performance of Chest CT with RT-PCR in Suspected Coronavirus Patients in Bangladesh.

A cross sectional study was conducted to demonstrate the value of Computed Tomographic (CT) scan in clinically suspected 114 COVID-19 patients with emphasis on identifying and characterizing the most common findings of chest CT. The CT findings were compared and correlated with the results of Reverse Transcriptase Polymerase Chain Reaction for corona virus disease. This study was conducted in the Department of Radiology and Imaging, Bangabandhu Sheikh Mujib Medical University, Dhaka with clinically COVID-19 suspected patients. This cross sectional study was performed from July 7 to August 7, 2020 where both chest HRCT and RT-PCR test were included, keeping RT-PCR as the reference standard. Of the 114 patients 104(91.22%) patients had ground glass opacities (with no consolidation), 50(43.85%) patients had ground glass opacity and consolidation. Along with ground glass opacities 60(52.63%) patients had associated crazy paving appearance, 44(39.59%) patients had reverse halo sign, 76(66.66%) patients had vascular thickening and 60(52.63%) patients had fibrotic shadows. Most patients (94%) (98/104) had bilateral chest CT findings. Out of 114 patients, 96 (84%) patients had positive RT-PCR results and 18(15.7%) patients had negative RT-PCR results. Out of 96 RT-PCR positive patients, 90 patients had positive chest CT findings, where was 06 patients had negative CT findings. On the other hand, out of 18 RT-PCR negative patients, 14 patients had positive chest CT findings while 4 patients had negative chest CT findings. To conclude, chest CT imaging has high sensitivity for diagnosis of COVID-19, Data and analysis from our study suggests that chest CT ought to be considered for the COVID-19 as a primary diagnostic tool for early detection of COVID-19 patients where awaited RT-PCR results.

Comparison of transabdominal and transvaginal sonography in the evaluation of uterine mass with histopathological correlation.

A cross-sectional study was conducted to demonstrate the role of transvaginal (TVS) and transabdominal sonography (TAS) to detect clinically suspected uterine mass in 53 patients which could not be differentiated clinically. The sonographic findings were compared and correlated with the findings of histopathology. TAS and TVS revealed 20(37.7%) & 20(37.7%) had leiomyoma, 12(22.6%) & 14(26.4%) had Ca cervix, 6(11.3%) & 7(13.2%) had endometrial carcinoma, 1(1.9%) & 1(1.9%) had hydatidiform mole respectively. TAS revealed 5(9.4%) had thickened endometrium, and no detectable mass were detected in 9(17.0%) cases. TVS revealed polyp in 7(13.2%), and no detectable mass were detected in 4(7.5%) cases. Histopathologically confirmed leiomyoma were in 18(34.0%) cases, Ca cervix in 14(26.4%), endometrial carcinoma in 6(11.3%), adenomyosis in 1(1.9%), polyp in 7(13.2%), chronic cervicitis in 2(3.8%), hydatidiform mole in 1(1.9%) and no detectable mass were detected in 4(7.5%) cases. Sensitivity of TAS and TVS to diagnose uterine mass were 83.7% and 95.9%, specificity 25.0% and 50.0%, positive predictive value 93.2% and 95.9%, negative predictive value 11.1% and 50.0% and accuracy 79.2% and 92.5% respectively. Sensitivity of TAS & TVS to diagnose leiomyoma was 88.9% & 94.9%, specificity 88.6% & 91.4%, positive predictive value 80.0% & 85.0%, negative predictive value 93.9% & 97.0%, and accuracy 88.7% & 92.5% respectively. Sensitivity of TAS & TVS to diagnose Ca cervix were 57.1% & 78.6%, specificity 89.7% & 92.3%, positive predictive value 66.9% & 78.6%, negative predictive value 85.4% & 92.3%, and accuracy 81.1% & 88.7% respectively. So, uterine mass can be evaluated more accurately by TVS than TAS.

Comparison of computed tomographic and cytopathological findings in the evaluation of adult orbital mass.

An observational study was conducted to demonstrate the role of Computed Tomographic (CT) scan to detect clinically suspected adult orbital mass in 47 patients which could not be differentiated clinically. The CT findings were compared and correlated with the findings of fine needle aspiration cytology (FNAC) or histopathology. CT diagnosis of optic nerve sheath meningioma were 12 cases, among them only nine cases confirmed cytopathologically as meningioma and rest three as lymphoma. Among ten cases of hemangioma, eight cases were confirmed cytopathologically as cavernous hemangioma and rest two were pseudotumor and chronic inflammatory lesion. Seven cases diagnosed as pseudotumor in CT were confirmed cytopathologically. Seven cases diagnosed as paranasal sinus masses with orbital extension (nasopharyngeal angiofibroma) in CT were confirmed cytopathologically. Among three cases of thyroid ophthalmopathy diagnosed in CT, only two cases confirmed cytopathologically and rest one cytopathologic diagnosis was not possible due to inadequate tissue supply during FNAC. Two cases of chronic inflammatory lesion diagnosed in CT, also confirmed cytopathologically. Two cases of metastatic lesion diagnosed in CT, also confirmed cytopathologically. Two cases of lacrimal gland tumor diagnosed in CT, also confirmed cytopathologically i.e., pleomorphic adenoma. Two cases of melanoma diagnosed in CT, only one confirmed cytopathologically and rest one cytopathologic diagnosis was not possible due to frank blood came out during FNAC. Pseudotumors were subsequently diagnosed the non-diagnostic cases on the basis of clinical and radiological findings. It is evident from these findings that CT is a useful modality in the diagnosis of adult orbital masses.