ABSTRACT
Between 1981 and 1991, eleven infants (ranging in age from 2 to 9 months) were hospitalized in our department for evaluation of microscopically verified scabies infestations. Six presented signs of Norwegian scabies. All of the latter infants had been treated (prior to the scabies infestation) for long periods with topical steroids, in most cases for lesions suggestive of atopic dermatitis. We believe that the occurrence of the Norwegian form in these newborns was due to localized steroid-induced suppression of the normal immune response.
Subject(s)
Immunocompromised Host , Sarcoptes scabiei/parasitology , Scabies , Animals , Dermatitis, Atopic/drug therapy , Dermatitis, Atopic/immunology , Female , Humans , Infant , Male , Prognosis , Scabies/diagnosis , Scabies/drug therapy , Scabies/immunology , Steroids/adverse effects , Steroids/therapeutic useABSTRACT
It has been suggested that leukocyte adhesion mechanisms play a key role in experimental myocardial infarction. We have recently shown that E-selectin, an adhesion molecule belonging to the selectin family, is involved in the pathogenesis of experimental myocardial ischemia. We investigated the circulating levels of E-selectin, studied as a marker of endothelial dysfunction, in acute myocardial infarction. Our study was carried out in 60 patients, 20 hospitalized for acute myocardial infarction, 20 suffered from angina pectoris and 20 healthy control subjects. Patients with acute myocardial infarction had increased serum levels of soluble E-selectin (sE-selectin = 255 +/- 12 ng/ml) compared to both patients with angina pectoris (sE-selectin = 51 +/- 14 ng/ml). Thrombolytic therapy with urokinase (1,000,000 IU as an intravenous bolus in 5 min, followed by producing reperfusion and reduced the serum levels of sE-selectin (71 +/- 19 ng/ml). Our results confirm previous experimental data and indicate that adhesion mechanisms supporting leukocyte-endothelium interaction may also be operative in human acute myocardial infarction.
Subject(s)
E-Selectin/blood , Myocardial Infarction/blood , Adult , Aged , Angina Pectoris/blood , Biomarkers/blood , Case-Control Studies , Cell Adhesion/physiology , Endothelium, Vascular/physiopathology , Female , Humans , Leukocytes/physiology , Male , Microcirculation/physiopathology , Middle Aged , Myocardial Infarction/drug therapy , Myocardial Infarction/etiology , Myocardial Reperfusion , Solubility , Urokinase-Type Plasminogen Activator/therapeutic useABSTRACT
A case of Lichen aureus in a 15-year old boy is presented. The case is particularly underlined due to lesions on both legs.
Subject(s)
Lichen Planus/pathology , Adolescent , Humans , Leg , MaleABSTRACT
A radiographic study of the hands, using the method of optical enlargement or 'microradioscopy', was carried out on a group of 58 psoriatic patients suffering from different clinical forms of the disease, but without clinical symptoms of arthropathy. A significant statistical incidence for the following lesions was revealed: (a) focal discontinuity and irregularity of the tuft cortical, similar to a nail-stroke; (b) focal lamellar thickening of the periosteum; (c) small intraspongous geodes; (d) increase of the intracortical striae; (e) small juxta-articular erosions. The radiological aspect of the hands, characterized by monolateral and variously combined lesions (with the almost constant presence of the erosions of the tuft cortical) is characteristic, enough to be recognized as a marker of the disease. The authors assume that psoriasis is a systemic disease characterized by accelerated turnover, and that cutaneous and bone lesions represent a different clinical expression of this same biological process.
Subject(s)
Arthritis/diagnostic imaging , Hand/diagnostic imaging , Psoriasis/diagnostic imaging , Adolescent , Adult , Aged , Arthritis/pathology , Bone and Bones/pathology , Child , Female , Humans , Male , Microradiography , Middle Aged , Psoriasis/pathologyABSTRACT
15 obese subjects were studied under different meal-timing schedules in order to see if meal-timing could affect the circadian pattern of energy expenditure. 4 subjects were given one meal (700 Kcal.) a day at h 10 in the morning (for 3 days) or at h 18 in the afternoon (for another 3 days). 4 subjects were given 3 meals (240 Kcal. each) at h 10, h14, h 18 for 3 days. 7 subjects were kept absolutely fasting for 36 hours. O2 consumption and CO2 production were measured minute by minute for 30' every 4 hours by means of a gas-analyser Mijnardht Oxicon II. Urine Samples were taken every 4 hours for urinary nitrogen determination. Energy expenditure was calculated according to Consolation's formula. Cosinor test was used to detect circadian rhythms. A statistically significative circadian rhythm of energy expenditure could be detected in all the protocols. The observed small differences among acrophases and the overlapping of confidence's ellipses allow to conclude that meal-timing doesn't affect the circadian rhythm of energy expenditure and suggest that this rhythm can be considered endogenous.
