[HYGIENIC SUBSTANTIATION OF THE DEVELOPMENT AND USE OF POLYGUANIDINES AS ANTIMICROBIAL PROPHYLACTIC MEANS OF THE INNOVATIVE CLASS].

In the article there are presented data of the system analysis of hygienic properties of polyguanidines (PAG) as an innovative class of domestic microbicidal chemical long-acting compounds synthesized in the domestic scientific institution--Institute ofenvironmental and technological problems, and also delivered on their base new disinfectants. Submitted proceedings of microbiological studies indicate to the antimicrobial action of PA G against Gram-negative and Gram-positive bacteria, viruses, dermatophytes, yeasts, fungi, including pathogens, as well infectious agent of swine and legionellosis. The data of toxicological studies of PAG and a number of derivative disinfectants justify their hygienic safety in dependence on the chemical nature of the used anion (A), the composition and structure of the polymer chain and also the content of residual monomers. All this characterizes PAG as a very promising group of compounds for the use in the form of independent disinfectants and as antimicrobial additives and auxiliaries in such means for different purposes.

Experimental study of the cross-sections of alpha-particle induced reactions on 209Bi.

alpha-particle-induced nuclear reactions for generation of (211)At used in therapeutic nuclear medicine and possible contaminants were investigated with the stacked foil activation technique on natural bismuth targets up to E(alpha)=39 MeV. Excitation functions are reported for the reactions (209)Bi(alpha,2n)(211)At, (209)Bi(alpha,3n)(210)At and (209)Bi(alpha,x)(210)Po. Results obtained from direct alpha-emission measurements and gamma-spectra from decay products are compared and correspond well with earlier literature values. Thick target yields have been deduced from the experimental cross-sections and optimised production pathways for minimal contamination are presented. A comparison with the results of the theoretical model code ALICE-IPPE is discussed.

Activation cross-sections of long-lived products of proton-induced nuclear reactions on zinc.

In the frame of a systematic study of excitation functions induced by medium energy protons, the activation cross-sections on natural zinc were investigated for different applications. Excitation functions for production of 66,67Ga, 62,65,69mZn, 64Cu, 57Ni, 55,56,57,58Co and 52,54Mn radioisotopes were measured by the stacked foil technique in the energy range of 26-67 MeV. Results were compared with the earlier reported experimental data and theoretical calculations based on the ALICE-IPPE code. Experimental data are presented for the first time for most of the products in the investigated energy range. Applications of the measured data for validating the cross-sections on highly enriched isotopic Zn targets and for thin layer activation method are discussed.