BACTERIAL CONTAMINATION AND METHODS OF DECONTAMINATION OF BASES COMPLETE REMOVABLE PROSTHESES DURING THE APPLICATION OF ADHESIVE MATERIALS.

It turned out that the permanent microbiota of surfaces of acrylic bases of complete removable plastic dentures (CRPD) characterized by several features: the presence of aerobic (7) and anaerobic (10) species. Qualitative and quantitative compositions of microbiocenosis in orthopedic treatment stages have been changed. The revealed patterns require further study in the context of the improvement of decolonization of acrylic bases in the stages of orthopedic treatment by CRPD. Deactivation of acrylic bases of CRPD significantly affects the species composition of microbiota, reduces the quantitative parameters of bacterial contamination. The purpose of our work was determination of bacterial contamination of acrylic bases of CRPD in stages of their clinical exploitation and study of changes in the quantitative composition of the acrylic bases microbiota of CRPD under different decontamination modes. Smears from the inner surface of the acrylic base were stained with Gram and microscopic and seeded on blood agar, Endo agar, Chistovich, Saburo. Species belonging to the micro-organisms were identified by the LAHEMA test system and were determined in colonies forming units (CFUs). These data indicate accumulation under the acrylic base in the course of clinical operation of certain types of microbiota, which requires improvement of the methods of their decontamination. We studied the change in the quantitative and specific composition of the microbiota (bacterial contamination) of acrylic bases CRPD under different modes ("A", "B"). Patients in group "A" used the Sideex solution - a two-component system consisting of a liquid component (glutaraldehyde solution) and a powdery activator, mixed before use to obtain a working activated solution. The liquid component is a clear, colorless solution with a specific odor, which is a 2.2-2.7% aqueous solution of glutaraldehyde, which is an active ingredient, pH=3.0 - 4.5. Powdery activator is a pale-yellow powder containing alkaline components, a corrosion inhibitor, and a dye. The activated working solution is a fluorescent green solution with a specific odor and containing 2.2-2.7% glutaraldehyde; pH=8.2-9.2. (Great Britain). Preparation of the activated solution: a powder-activator is added to the container containing the liquid component (avoiding losses). Cleaning is carried out by the method of full immersion of the prosthesis in solution, with a thickness of the drug over it not less than 1 cm. The dentures are soused in solution for 15 minutes, then thorough washing in the same solution for 1-3 minutes. Sideex activated solution is used for sterilization and disinfection of metal, glass, polymeric (plastic, rubber, etc.) medical products. The dentures of patients from group "B" are decontaminated with 0.2% solution of chlorhexidine bigluconate. The dentures were placed in the solution overnight for 14 days, changing the solution every two days. The decontamination of acrylic bases of CRPD should be considered mode "B" as more effective because of the significant decrease in the species composition of the microbiota (the qualitative indicator of reduction of microbial contamination was 72.0%). It is substantiated that decontamination of acrylic bases of CRPD with mode "A" has a small effect on the species composition of the microbiota, although it significantly (p<0.05) reduces quantitative indicators of microbial contamination. Regarding "B" mode, the species composition of aerobes from 31 lgCFU/ml to 8.7 lgCFU/ml and anaerobes from 42.7 lgCFU/ml to 14.6 lgCFU/ml was considered more effective.

ANTI HOMOTOXIC DRUGS USING IN DENTAL PRACTICE.

In modern conditions, against the background of increasing numbers of complications when using potent chemicals, it became necessary to looking for alternative medicines, such as homeopathic medicines. The aim of this review article is to prove the importance of further research of the antihomotoxic drugs (AHTD) using, which are an integral part of homeopathic therapy, for the complex treatment of diseases of the maxillofacial region of various genesis, taking into account the mechanism of action of this group of homeopathic medicines. More than 30 scientific sources of the antihomotoxic drug "TRAUMEEL®S" using in treatment of inflammatory diseases of the maxillofacial region, as well as the use of homeopathic medicines to prevent the development of necrotic phenomena in the pulp of tooth have been processed. The importance of further studies on the use of antihomotoxic drugs, which are an integral part of homeopathic therapy, for the complex treatment of diseases of the maxillofacial region of various origin, taking into account the mechanism of action of this group of homeopathic drugs have been substantiated. The therapy with antihomotoxic drugs, namely, "TRAUMEEL®S", produces positive results in treatment of various inflammatory processes of the maxillofacial area in various dental diseases.

EXPERIMENTAL JUSTIFICATION OF A METHOD-OF-CHOICE TO PROTECT THE RECEPTOR APPARATUS OF THE TEETH, SUPPORTING A NON-REMOVABLE DESIGN DENTURE.

In the article presents the results of experimental research on laboratory animals, the influence of the domestic light-cured adhesive complex and the anti-homo-toxic drug "Traumel" (Hell) on the receptor apparatus of the teeth, used for supporting the non-removable one-piece-cast design denture which facing with ceramics or plastics, after the operation of grinding of the hard tissues. In the course of the research, it was established that the use of this complex allows to obtain a complete regeneration of odontoblast processes damaged as a result of the operation of the grinding and thereby to prevent the occurrence of possible complications of this manipulation. In addition, the use of the above complex allows you to keep the teeth used for supporting the non-removable one-piece-cast design denture, vital and thus prevent possible fractures of the crowns of natural teeth, and thus extend the terms of use of these structures. The results of the study were confirmed by histological studies, which confirmed the positive effect of this complex. Studies were conducted after 1 week, 2 weeks and one month later. A clear positive result was detected in 1 month when there was a complete regeneration of odontoblast processes with side branches and with maximally expressed, relatively control observations, of accumulation of protein in the cytoplasm. Thereby, the obtained results provided the basis for the development of a method for the protection of intact teeth used for supporting non-removable design denture, thuse preventing the development of complications and prolonging the use of these types of orthopedic denture.

[Comparative data charasteristic of laboratory examination of patients with chronic heart failure of ishemic origin with systolic left ventricular dysfunction and preserved left ventricular ejection fraction].

581 patients with chronic heart failure (CHF) of ischemic origin with systolic left ventricular dysfunction (SLVD) and preserved left ventricular ejection fraction (PLVEF) were examined. The aim of the study was to investigate the comparative aspect of laboratory examination of patients with chronic heart failure of ischemic origin with left ventricular systolic dysfunction and patients with heart failure and preserved left ventricular ejection fraction. The study found no differences in the groups on the basic parameters: the number of white blood cells, hemoglobin concentration, red blood cell count, platelet count, the number of potassium and sodium ions. At the same time, patients with CHF and left ventricular systolic dysfunction characterized by the presence of a moderate decline in glomerular filtration rate, including more frequent patients with lymphocytopenia, hypoholesteremia, hyperuricemia. For patients with chronic heart failure and preserved left ventricular ejection fraction the following characteristics have been characterized: normal or increased glomerular filtration rate, hypercholesterolemia.

[Survival for 48 months, survival predictors in patients with chronic heart failure of ischemic origin with systolic left ventricular dysfunction and preserved left ventricular ejection fraction].

354 patients with chronic heart failure (CHF) of ischemic origin with systolic left ventricular dysfunction (SLVD) and 227 patients with preserved left ventricular ejection fraction (PLVEF) were examined. This study was aimed at the studying of comparative aspect of survival of patients with CHF and SLVD and with PLVEF for 48 months of observation, and the studying of nonsurvival predictors. Survival of patients with PLVEF is significantly better compared with survival of patients with SLVD for 48 months (66% and 42% respectively). The most informative predictors of 48 month in patients with SLVD were: uric acid level (OR = 3,17), end-systolic volume (OR = 2,71), hemoglobin level (OR = 2,64), creatinine level (OR = 2,36), end-dyastolic volume (OR = 2,49), index of end-systolic volume (OR = 2,44). The most informative predictors in patients PLVEF were: cholesterol level (OR = 2,14) and distance of 6-minute walk (OR = 2,11).