ABSTRACT
Thirty six male goats grazing Caatinga native pasture were randomly assigned to 4 concentrate supplementation levels (0, 5, 10 and 15g/kg of body weight) and slaughtered after 120days. Longissimus muscle meat lipids were extracted and fractionated into neutral (NL) and polar (PL) lipids. Supplementation of grazing goats increased linearly (P<0.05) intramuscular fat (1 to 1.5% of meat) and NL (0.3 to 1% of meat) but decreased linearly (P=0.044) the PL (0.66 to 0.50% of meat). On NL, supplementation increased linearly (P=0.047) the proportion of c9-18:1 (31 to 40% of FA) with supplementation. On PL, supplementation reduced linearly (P<0.03) the dimethyl acetals, 18:3n-3 and most of long chain polyunsaturated FA (PUFA) proportions but increased linearly (P<0.001) the c9-18:1. Considering the total meat FA, supplementation led to an increase of the saturated and monounsaturated FA contents and a decrease of the long chain n-6 and n-3 PUFA contents.
Subject(s)
Diet/veterinary , Fatty Acids/analysis , Red Meat/analysis , Animal Feed/analysis , Animals , Brazil , Dietary Supplements , Goats , Lipids/chemistry , Muscle, Skeletal/chemistrySubject(s)
Adult , Middle Aged , Humans , Male , Female , Hypertension , Indoles , Methyldopa , Drug Therapy, CombinationABSTRACT
Foi realizado um ensaio clinico a longo prazo, com a associacao de oxprenolol SR 160 mg + clortalidona 20 mg, em 24 pacientes com hipertensao arterial essencial nao complicada (estagios I e II da OMS). Os pacientes foram submetidos a uma fase inicial com placebo. A seguir receberam 1 dragea de combinacao fixa de oxprenolol de liberacao gradativa 160 mg + clortalidona 20 mg em dose unica diaria, durante 15 dias; apos este periodo a dose seria duplicada caso a PA diastolica fosse superior a 90 mmHg (fase V de Korotkoff). A duracao total do estudo com droga ativa foi de 15 meses. Ao termino do tratamento, 21 pacientes (87,5%) mantinham uma PA diatolica menor ou igual a 90 mmHg (supina). Este estudo demonstrou que a associacao acima e efetiva e bem aceita pelos pacientes com hipertensao arterial essencial nao complicada