Factors that influence the efficacy of topical gentamicin prophylaxis for experimental Pseudomonas keratitis.

We evaluated the efficacy of topical gentamicin prophylaxis for experimental Pseudomonas keratitis in rabbits by applying gentamicin in concentrations of 0.3 and 4 mg/100 ml, in both solution and ointment vehicles, one or four hours after a superficial stromal scratch was infected topically with Pseudomonas organisms. Under these conditions the most effective prophylaxis was that given early, in solution, and in high concentration.