ABSTRACT
Primary liposarcomas of the mediastinum are unusual tumors. We report herein a case of a 52-year-old woman, who was found to have a mediastinal tumor involving both hemithoraces and radiologically showing non-resectable-invasive features to the adjacent vital structures. She had a history of left thoracotomy for mediastinal schwannoma 14 years previously. The patient underwent an exploratory thoracotomy following a preoperative misdiagnosis of an ancient schwannoma. Complete removal of the tumor was accomplished through a right posterolateral thoracotomy with a subsequent histological diagnosis of a recurrent low-grade liposarcoma. A resectable liposarcoma should be considered in the differential diagnosis of a mediastinal tumor, although radiologically, the tumor presents with invasive features.
Subject(s)
Liposarcoma/surgery , Mediastinal Neoplasms/surgery , Neoplasm Recurrence, Local/surgery , Diagnostic Errors , Female , Humans , Liposarcoma/diagnosis , Liposarcoma/pathology , Mediastinal Neoplasms/diagnosis , Mediastinal Neoplasms/pathology , Middle Aged , Neoplasm Recurrence, Local/diagnosis , Neurilemmoma/diagnosisABSTRACT
OBJECTIVE: Surgery is the optimal treatment in patients with non-small cell lung cancer (NSCLC) and tumor-negative bronchial resection margins should be maintained for a curative resection. The epidemiology of NSCLC, including the aspects of tumor localization, has been changing during the recent decades. The aim of this study was to evaluate microscopic proximal bronchial extension with special reference to the site of the tumor. METHODS: Surgical specimens of 70 NSCLC cases were examined histologically for proximal bronchial extension of the tumor. The entire bronchial tree with the tumor was extracted from the specimen and serially cut at a thickness of 5 mm in the transverse plane of the bronchus. Microscopic proximal extension of the tumor was classified as either endobronchial or peribronchial. RESULTS: Thirty-three (47.1%) tumors had central and 37 (52.9%) had peripheral localization. Among the central and peripheral tumors, 10 (30.3%) and seven (18.9%) had microscopic proximal extension, respectively. In total, the mean length of proximal extension was 10.94 +/- 7.07 mm. The mean length of extension for peripheral tumors was 15.71 +/- 8.38 mm, significantly greater than that of central tumors, which was 7.60 +/- 3.47 mm (P = 0.026). Peripheral tumors showed a significant peribronchial extension (P = 0.024). CONCLUSIONS: A greater percentage of central tumors show microscopic proximal bronchial extension, whereas the length of microscopic proximal bronchial extension is significantly greater in peripheral tumors. Peripheral tumors preferentially have a peribronchial extension pattern.
Subject(s)
Adenocarcinoma/pathology , Bronchi/pathology , Carcinoma, Squamous Cell/pathology , Lung Neoplasms/pathology , Pneumonectomy , Adenocarcinoma/surgery , Adult , Aged , Bronchi/surgery , Carcinoma, Squamous Cell/surgery , Female , Humans , Lung Neoplasms/surgery , Male , Middle Aged , Neoplasm Invasiveness , Retrospective StudiesABSTRACT
We report a case of a 46-year-old man who presented with a chest wall tumor in the right hemithorax. He underwent thoracotomy to remove the mass, which was found to be an arteriovenous hemangioma arising from the intercostal muscle. Arteriovenous hemangioma is a rare tumor and chest wall is an extremely rare site for this tumor. This tumor should be considered in the differential diagnosis of the chest wall tumors. Complete surgical excision offers the best treatment.
Subject(s)
Hemangioma/diagnosis , Hemangioma/surgery , Intercostal Muscles , Muscle Neoplasms/diagnosis , Muscle Neoplasms/surgery , Thoracic Neoplasms/diagnosis , Thoracic Neoplasms/surgery , Biopsy , Diagnosis, Differential , Duodenal Ulcer/complications , Hemangioma/complications , Humans , Male , Middle Aged , Muscle Neoplasms/complications , Pain/complications , Thoracic Neoplasms/complications , Thoracotomy , Tomography, X-Ray ComputedABSTRACT
PURPOSE: The pathogenesis of pterygium is still not completely understood and many environmental factors, including ultraviolet (UV) radiation, play an important role in its etiology. Chronic exposure to UV radiation causes mutations in the p53 tumor suppressor gene, eventually leading to tumor formation. We analyzed the immunohistochemical expression of p53 proteins in pterygial tissues to determine the role of the p53 tumor suppressor gene in the development of pterygium. METHODS: Pterygial specimens were studied immunohistochemically using antibodies against p53 protein. RESULTS: Out of 38 specimens studied, 35 (92.1%) had conjunctival epithelial cells without p53 specific nuclear staining. Only three specimens (7.9%) had a few p53 stained cells. The role of UV radiation in the pathogenesis of pterygium is supported by epidemiological, geographical and microscopic findings. However, our results are not consistent with these data on a genetic basis. CONCLUSIONS: We conclude that defective p53 tumor suppressor gene function seems to have no role in the pathogenesis of pterygium.
Subject(s)
Pterygium/metabolism , Tumor Suppressor Protein p53/biosynthesis , Adult , Aged , Biomarkers , Environmental Exposure/adverse effects , Female , Humans , Immunohistochemistry , Male , Middle Aged , Mutation , Pterygium/etiology , Pterygium/pathology , Tumor Suppressor Protein p53/genetics , Tumor Suppressor Protein p53/radiation effects , Ultraviolet Rays/adverse effectsSubject(s)
Amyloid/metabolism , Amyloidosis/metabolism , Thyroid Gland/metabolism , Adolescent , Adult , Biopsy, Needle , Female , Humans , Male , Middle AgedABSTRACT
The combined effect of acetylsalicylic acid (ASA) and misoprostol (MISO) on adjuvant arthritis was investigated on rats. Alteration by various doses of MISO and fixed dose of ASA was studied. Drugs were given by the nasogastric route each day beginning from the day of adjuvant injection (day 0) and continued until the 16th day. Paw swelling was measured on days 4, 17, and 29, and secondary lesions were assessed on days 17 and 29. Pathological examination of tibiodorsal junction was also evaluated on the 29th day. The results clearly showed that the combination of MISO with ASA did not inhibit the antiinflammatory effect of ASA. Unexpectedly, MISO increased the antiinflammatory effect of ASA at some dosage regimens.
