Subject(s)
Calcium/metabolism , Cardiac Output/drug effects , Heart/physiopathology , Myocardium/metabolism , Shock, Cardiogenic/physiopathology , Adenylyl Cyclase Inhibitors , Adenylyl Cyclases/metabolism , Animals , Aprotinin/pharmacology , Aprotinin/therapeutic use , Disease Models, Animal , Dogs , Enzyme Inhibitors/pharmacology , Enzyme Inhibitors/therapeutic use , Heart/drug effects , Hemodynamics/drug effects , Molybdenum/pharmacology , Molybdenum/therapeutic use , Myocardium/enzymology , Protein Kinase Inhibitors , Protein Kinases/metabolism , Sarcoplasmic Reticulum/enzymology , Sarcoplasmic Reticulum/metabolism , Shock, Cardiogenic/drug therapy , Shock, Cardiogenic/enzymology , Shock, Cardiogenic/metabolism , Ventricular Function, Left/drug effectsABSTRACT
It was shown on dog experiments that disorders in the phosphorylation-proteolysis-calcium transport system in the sarcoplasmatic reticulum of pathologically changed myocardium are an important component of cardiac activity depression in massive blood loss. Low cardiac output can be corrected by ammonium molibdate, phosphoprotein phosphatase inhibitor, and contrycal, proteolysis inhibitor.
Subject(s)
Aprotinin/therapeutic use , Cardiac Output, Low/drug therapy , Coloring Agents/therapeutic use , Hemostatics/therapeutic use , Molybdenum/therapeutic use , Myocardium/cytology , Phosphoprotein Phosphatases/antagonists & inhibitors , Serine Proteinase Inhibitors/therapeutic use , Trypsin Inhibitors/therapeutic use , Animals , Cardiac Output, Low/etiology , Cardiac Output, Low/metabolism , Dogs , Hemorrhage/complications , Models, Theoretical , Sarcoplasmic Reticulum/metabolismABSTRACT
The possibility of involvement of thyroid hormones and melatonin in cell protection from damage by active oxygen forms (hydroxyperoxide, superoxide radical, and hypochlorite) was investigated. The intensity of inhibition of luminol-dependent chemiluminescence induced by neutrophils and active oxygen forms in the presence of hormones was evaluated. Antioxidant activities of the enzymes were compared with that of glutathione. Probable mechanisms of antioxidant effect of the studied hormones are discussed.