1.
Chem Commun (Camb)
; 58(57): 7928-7931, 2022 Jul 14.
Article
in English
| MEDLINE
| ID: mdl-35758206
ABSTRACT
The site-selective chemical appendage of multiple functionalities on a native peptide backbone is a highly demanding and complex tool of modern chemical biology. Here, novel NHS-activated acrylates were designed to hold various payloads in a single bioconjugation handle that is able to site-selectively and orthogonally target the N-terminal cysteine of peptides.