The effects of S-adenosyl-L-methionine-vitamin B complex on mild and moderate depressive symptoms.

BACKGROUND: S-adenosyl-L-methionine (SAMe) acts as a methyl donor, with dopamine, norepinephrine, and serotonin elevating properties, with potential antidepressant effects. In this study, we evaluated the efficacy of SAMe-vitamin B complex supplement for improving mild and moderate depressive symptoms. SUBJECTS AND METHODS: The study included 60 patients diagnosed with depression, with mild or moderate depressive symptoms, randomly allocated into two groups. The study group was treated with SAMe-vitamin B complex while the control group was administered a placebo, once daily for three months. The severity of depressive symptoms was measured by the Hamilton Depression rating scale (HAMD17). We measured the symptoms' severity with the Clinical Global Impression-Severity scale (CGI-S), and the improvement or worsening after treatment with the Clinical Global Impression-Improvement scale (CGI-I). RESULTS: The mean HAMD17 score at zero point refers to moderate depressive symptoms in both groups. We found a statistically significant difference between the two groups regarding the mean HAMD17 and CGI-S scores at three months (p <0.001) and a significant difference within the study group without an influence by the age or gender. Mean CGI-I score in the study group at three months showed minimally or much improvement while no change or minimal worsening was observed in the control group with significant differences between the groups (p <0.001). CONCLUSION: Three months of supplementation with SAMe-vitamin B complex is effective for the treatment of mild to moderate depressive symptoms. HIPPOKRATIA 2017, 21(3): 140-143.

[Manifestations of epileptic seizures after acute cerebrovascular disease]. / Pojava epileptickih napada nakon akutnih cerebrovascularnih bolesti.

The study included 80 patients hospitalized in Intensive Care Unit, in whom was with confirmed the occurrence of seizures after acute cerebrovascular diseases. They were classified according to sex, age, etiopathogenesis of stroke, latence from the onset of cerebrovascular disease to the occurrence of first seizure, hemispheric and intrahemispheric localization of cerebrovascular lesion, and clinical types of seizures.

[Association of manifestations of acute stress disorder and acute cerebrovascular disease]. / Udruzena pojava akutnog stresnog poremacaja i akutne cerebrovaskularne bolesti.

The study comprised 32 patients who were with clinically, laboratory and neuroradiologically confirmed associated occurrence of acute stress disorder and stroke. All the examinees were civilians exposed to war stress, so it could be directly designated as the cause of acute stress disorder and indirectly denoted as a trigger of cardiovascular, endocrine and cerebrovascular disorder that brought to stroke.

[Evaluation of the level of depression and dementia in patients with primary chronic active epilepsy using the Dementia Mood Assessment Scale]. / Procena stepena depresije i demencije klinickom DMAS skalom kod bolesnika sa primarnom hronicnom aktivnom epilepsijom.

The study included 40 patients, aged 18-40 years with primary chronic active epilepsy, tested by clinical DMAS scale. We have found that the level of intelectual function damage (dementia) and mood (depression) rates depended on the long duration of epilepsy and the frequency of seizures, less on the frequency of specific EEG findings. Types of epileptic seizures and polytherapy influenced the depression and dementia rates the least in previous epilepsu treatment.

[Association of manifestations of chronic post-traumatic stress disorders and disseminated demyelinating disease of the central nervous system]. / Udruzena pojava posttraumatskog stresnog poremecaja hronicnog toka i diseminovanog demijelinizacijskog oboljenja centralnog nervnog sistema.

The study included 7 patients who were with clinically, laboratory, neurophysiologically and neuroradiologically confirmed associated occurrence of posttraumatic stress disorder of chronic course and disseminated demyelinating disease of the central nervous system. All the examinees were extendedly exposed to war stress, so it could be directly designated as the cause of posttraumatic stress syndrome and indirectly denoted as the trigger of immune disorder that brought to disseminated demyelination of the central nervous system.