ABSTRACT
Stimulation of the ventro-medial nuclei of the hypothalamus led to reduction in the concentration of phospholipids, triglycerides, and cholesterol in the mitochondria of the rabbit heart. Cholesterol load against this background elevated the concentration of cholesterol and reduced the phospholipid concentration even more. The heart mitochondrial and microsomal activity of Ca2+--ATP-ase was reduced. These data differed from the results recieved in the action of cholesterol alone. The research carried out showed that the action of exogenous cholesterol depended on the mechanisms regulating the lipid metabolism.
Subject(s)
Adenosine Triphosphatases/metabolism , Heart/physiology , Hypothalamus/physiology , Lipid Metabolism , Myocardium/metabolism , Animals , Calcium , Cholesterol, Dietary/administration & dosage , Electric Stimulation , Enzyme Activation , Hypothalamus, Middle/physiology , Male , Microsomes/metabolism , Mitochondria, Muscle/metabolism , RabbitsABSTRACT
Short-time disturbances of the microcirculation in rabbits had a different influence on the ATP-ase activity of smooth and rough microsomes of the liver and heart. Mg+2ATP-ase activity in the liver decreased in both microsome fractions; as in the heart, the enzyme activity increased only in the smooth (light) microsomes.
Subject(s)
Adenosine Triphosphatases/metabolism , Microcirculation/drug effects , Microsomes, Liver/enzymology , Microsomes/enzymology , Myocardium/enzymology , Acute Disease , Animals , Coronary Disease/enzymology , Dextrans/pharmacology , Enzyme Activation , Glucose-6-Phosphatase/metabolism , Male , Rabbits , Time Factors , Vasopressins/pharmacologyABSTRACT
It was shown that intravenous injection of vasopressin in a dose of 5 pressor units per 1 kg of body weight led to changes in the ATP-ase activity of the heart and liver microsomes in one hour. These changes coursed in a different direction, i.e. ATP-ase activity of the heart microsomes increased, and ATP-ase activity of the liver microsomes decreased.
