ABSTRACT
Sodium humate from peat of Tomsk region was tested on three animal models of allergic reaction. It was found that sodium humate suppresses the development and reduces the intensity of anaphylactic shock in guinea pigs and decreases the intensity of the delayed hypersensitivity reaction to goat erythrocytes. It is suggested that sodium humate can be a promising substance for the treatment of allergic states.
Subject(s)
Anti-Allergic Agents/pharmacology , Humic Substances , Hypersensitivity/immunology , Soil , Anaphylaxis/immunology , Animals , Anti-Allergic Agents/isolation & purification , Disease Models, Animal , Erythrocytes/immunology , Guinea Pigs , Hypersensitivity, Delayed/immunology , Russia , SheepABSTRACT
The hemorheological activity of a dry extract from Rhaponticum (Leuzea) carthamoides (Willd.) Iljin. was studied in spontaneously hypertensive rats (SHRs). A 14-day treatment of the test rats with a daily dose of 150 mg/kg improved the rheological characteristics, as manifested by a reduced viscosity of the whole blood and plasma, increased spontaneous erythrocyte aggregation and fibrinogen concentration, and increased erythrocyte deformability and electrophoretic mobility against the untreated control level.
Subject(s)
Antihypertensive Agents/therapeutic use , Hypertension/drug therapy , Phytotherapy , Plant Extracts/therapeutic use , Plants, Medicinal/chemistry , Rheology/drug effects , Animals , Cell Aggregation/drug effects , Electrophoresis , Erythrocyte Deformability/drug effects , Fibrinogen/metabolism , Male , Plant Extracts/pharmacology , Rats , Rats, Inbred SHR , Rats, WistarABSTRACT
The hemorrheological effects of extracts from Maltese cross campion (Lychnis chalcedonica L.) prepared using 40% (I) and 70% (II) aqueous ethanol solutions were studied in vitro in comparison with tanakan on the model of high blood viscosity syndrome. Under the hyperthermia conditions, extracts I and II at a concentration of 1 x 10(-5) g/ml limited the growth of blood viscosity and thrombocyte aggregation and the drop in thrombocyte deformability. The effects of both extracts were comparable to those of tanakan. Prolonged (5 days) administration of extract I (daily dose, 150 mg/kg p.o) in rats with arterial hypertension (SHR) decreased the viscosity of whole blood and plasma, reduced the concentration of fibrinogen, and increased the deformability of erythrocytes. No reliable effects of the extracts in vivo upon the erythrocyte aggregation and hematocrit were observed.
