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Prolonged linezolid use is associated with the development of linezolid-resistant Enterococcus faecium.
Smith, Tiffeny T; Tamma, Pranita D; Do, Tiffany B; Dzintars, Kathryn E; Zhao, Yuan; Cosgrove, Sara E; Avdic, Edina.
Diagn Microbiol Infect Dis ; 91(2): 161-163, 2018 Jun.
Article in English | MEDLINE | ID: mdl-29496381

ABSTRACT

We assessed risk factors for and outcomes of linezolid-resistant vancomycin-resistant Enterococcus faecium (LRVREF) bacteremia over 7 years. Thirty-four LRVREF cases were matched to 68 linezolid-susceptible VREF controls. The odds of bacteremia with LRVREF increased by 7% for each additional day of prior linezolid exposure.


Subject(s)
Anti-Bacterial Agents/pharmacology , Drug Resistance, Multiple, Bacterial/drug effects , Enterococcus faecium/drug effects , Gram-Positive Bacterial Infections/microbiology , Linezolid/pharmacology , Vancomycin-Resistant Enterococci/drug effects , Adult , Aged , Anti-Bacterial Agents/therapeutic use , Female , Gram-Positive Bacterial Infections/drug therapy , Humans , Linezolid/therapeutic use , Male , Middle Aged , Retrospective Studies , Time Factors
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