[The prognostic significance of changes in the level of natural antibodies to thrombin in stenocardia patients]. / Prognosticheskaia znachimost' izmenenii urovnia estestvennykh antitel k trombinu u bol'nykh stenokardiei.

Coagulation in angina pectoris has been analyzed in a normal and elevated level of natural antibodies (nAb) to thrombin. A correlation was found between the level of nAb to thrombin and hemostatic shifts. The correlation of a nAb rise was attempted by means of plasmapheresis (PA) or plasmosorption (PS), altering coagulation potential. PA and PS produced more pronounced anticoagulative effects in patients with a normal baseline level of nAb to thrombin. When the latter levels tended to reduction from initially high, hemostatic processes improved. It is concluded that nAb to thrombin levels have prognostic potential as an indicator of coagulation activity and efficacy of anticoagulant therapy in extracorporeal interventions.

[Role of hemorheologic and hemodynamic factors for the efficacy of therapeutic plasmapheresis in patients with ischemic heart disease]. / Rol' gemoreologicheskikh i gemodinamicheskikh faktorov v éffektivnosti lechebnogo plazmafereza u bol'nykh ishemicheskoi bolezn'iu serdtsa.

Changes in blood rheological properties and central hemodynamic parameters were studied in patients with Functional Classes III-IV angina pectoris who had undergone therapeutical plasmapheresis. Drastic baseline changes in blood rheological properties, a reduction in myocardial contractility, and high total peripheral vascular resistance (hypokinetic circulation) were found to be indications for plasmapheresis supplemented to antianginal therapy. A positive clinical effect of this therapeutical method may be, to a definite extent, predicted in these patients. The first plasmapheresis procedure improved blood rheology due to the plasma component, making the high baseline levels of fibrinogen and total protein normal, lowered increased platelet aggregation, repeated procedures enhanced the electric superficial charge of red blood cells and the stroke index of the left ventricle.

[Effect of therapeutic plasmapheresis on rheological properties of blood in patients with ischemic heart disease]. / Vliianie lechebnogo plazmafereza na reologicheskie svoistva krovi u bol'nykh ishemicheskoi bolezn'iu serdtsa.

Patients with angina pectoris, functional classes III-IV, were examined for changes in the rheological blood properties (red blood cell aggregation ratio, fluidity limit, apparent viscosity, electrophoretic mobility of red blood cells, fibrinogen, total plasma protein and ADP, induced platelet aggregation) under the effect of continuous plasmapheresis (PA). PA was established to produce a selective effect on the rheological blood properties depending on the initial level of its disorders. The most remarkable clinical effect was produced by PA in patients with initially high characteristics of hemorheology. The first PA session ameliorated hemorheology at the expense of the plasma component, reduced high platelet aggregation whereas the repeated sessions largely affected red blood cell function.

[Morphofunctional properties of the blood cells in patients with ischemic heart disease following gravitational correction]. / Morfofunktsional'nye svoistva kletok krovi u bol'nykh ishemicheskoi bolezn'iu serdtsa posle gravitatsionnoi korrektsii.

Red cell and platelet surface membranes, platelet adhesion to glass were examined in coronary patients treated among other treatment modalities with gravitation surgical correction of the blood. Scanning electron microscopy was used in the study. The studies revealed the minimal injurious effect of the extracorporeal contour on blood cells; a manifest improvement of cellular morphology and function was observed after a course of procedures. An attempt was made to assess the mechanism of gravitation surgery effect on blood cells.

[Correction of hypercholesterolemia and dyslipoproteinemia by plasmapheresis in patients with stenocardia resistant to drug therapy]. / Korrektsiia giperkholesterinemii i dislipoproteidemii metodom plazmafereza u bol'nykn so stenokardiei, rezistentnoi k medikamentoznoi terapii.

Plasmapheresis was used to correct blood lipid composition in patients with angina at rest and angina of effort (functional classes 3-4). In addition to a drop in total cholesterol and triglycerides, cholesterol in low and very-low-density lipoproteins fell abruptly, while high-density-lipoprotein cholesterol, on the contrary, increased considerably. Clinical improvement of the patients was also recorded.

[Evaluation of the antithrombotic effect of plasma and thrombocyte apheresis in the complex therapy of patients with unstable stenocardia]. / Otsenka protivotromboticheskogo éffekta afereza plazmy i trombitsitov v kompleksnoi terapii bol'nykh s nestabil'noi stenokardiei.

Antithrombotic effect of plasmapheresis and thrombocytapheresis, used as part of combined treatment in 12 patients with unstable medication-resistant angina pectoris of functional class 4, was assessed by means of coagulation tests and resonance thrombography. The incorporation of three sessions of apheresis, removing 90% of plasma and 30% of platelet population, into the conventional treatment schedule is shown to have an anticoagulant, thrombolytic and platelet hypersensitivity-controlling effect. It is directly related to the volume of removed plasma and platelets, allows control of prethrombotic conditions and paves the way for an adequate response to subsequent medication.

[Use of plasma- and thrombocytapheresis in patients with stenocardia]. / Primenenie plazma-i trombotsitafereza u bol'nykh so stenokardiei.

Marked microcirculatory changes, hemorheologic and immunologic disorders were found in anginal patients. Plasmapheresis with repeated thrombocytopheresis sessions as part of combined treatment improves these parameters, the improvement correlating with a stable clinical remission.