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Boll Chim Farm ; 139(5): 209-12, 2000.
Article in Spanish | MEDLINE | ID: mdl-11213439

ABSTRACT

The production of polymeric complexes in many active drugs with reticulated povidone increased dissolved component percentage. In this work made use a coevaporation technique. Complex formation has been tested by X Ray Diffractometry and Differential Scanning Calorimetry. The percentage of dissolution was determined to the USP XXIII Edition methodology. As can be seen from the results, the Atenolol-reticulated Povidone complexes has greater solubility than the Atenolol mixed with Lactose as excipient.


Subject(s)
Adrenergic beta-Antagonists/chemistry , Atenolol/chemistry , Povidone/chemistry , Adrenergic beta-Antagonists/administration & dosage , Atenolol/administration & dosage , Calorimetry, Differential Scanning , Drug Compounding , Pharmaceutic Aids , Solubility , X-Ray Diffraction
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