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1.

[Experimental chemotherapy of alveolar hydatid disease. 12. The efficacy of drug forms of mebendazole and nocodazole with high bioavailability]. / Eksperimental'naia khimioterapiia al'veokokkoza. Soobshchenie 12. Effektivnost' lekarstvennykh form mebendazola i nokodazola s povyshennoi biostupnost'iu.

Dzhabarova, V I; Dobrotvorskii, A E; Krotov, A I.

Med Parazitol (Mosk) ; (5): 43-6, 1989.

Article in Russian | MEDLINE | ID: mdl-2615711

ABSTRACT

New formulations have been designed to increase the efficacy and bioavailability of the oral drugs mebendazole and nocodazole and were tested in CBA mice. A considerable increase in efficacy was established for a solid disperse formulation of certain composition with a relatively lower toxicity than in aqueous suspensions of the drugs.

Subject(s)

Echinococcosis/drug therapy , Mebendazole/administration & dosage , Nocodazole/administration & dosage , Administration, Oral , Animals , Biological Availability , Drug Evaluation, Preclinical , Injections, Intramuscular , Mebendazole/pharmacokinetics , Mebendazole/toxicity , Mice , Mice, Inbred CBA , Nocodazole/pharmacokinetics , Nocodazole/toxicity , Solubility , Suspensions

2.

[Quality requirements and evaluation of water used in pharmaceutical practice]. / Trebovaniia i otsenke kachestva vody, ispol'zuemoi v farmatsevticheskoi praktike.

Chirkov, A I; Zhurko, V V; Dobrotvorskii, A E; Abduvakhabov, K R.

Voen Med Zh ; (10): 56-8, 1987 Oct.

Article in Russian | MEDLINE | ID: mdl-3433689

Subject(s)

Technology, Pharmaceutical , Water/standards

3.

[Experimental study of the chemotherapy of echinococcosis using intramuscular injections of a mebendazole suspension]. / Izuchenie khimioterapii ékhinokokkozov putem vnutrimyshechnykh in" ektsii suspenzii mebendazola v éksperimente.

Krotov, A I; Dzhabarova, V I; Pereverzeva, E V; Lopatin, B V; Dobrotvorskii, A E.

Med Parazitol (Mosk) ; (5): 61-3, 1983.

Article in Russian | MEDLINE | ID: mdl-6646057

Subject(s)

Benzimidazoles/administration & dosage , Echinococcosis/drug therapy , Mebendazole/administration & dosage , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Injections, Intramuscular , Mice , Particle Size , Rats , Suspensions , Time Factors

4.

[Streptocide release from emulsion ointment bases]. / Izuchenie vysvobozhdaemosti streptotsida iz émul'sionnykh mazevykh osnov.

Dobrotvorskii, A E; Aleksandrova, S M; Aliushin, M T; Riaposova, O I.

Farmatsiia ; 27(4): 70-1, 1978.

Article in Russian | MEDLINE | ID: mdl-689190

Subject(s)

Sulfonamides/pharmacology , Emulsions , Kinetics , Ointment Bases

5.

[Assessment of the degree of streptocide release from ointments by the "flow" dialysis method]. / Otsenka stepeni vysvobozhdeniia streptotsida iz mazei metodom "protochnogo" dializa.

Dobrotvorskii, A E; Tentsova, A I; Aliushin, M T.

Farmatsiia ; 26(6): 40-2, 1977.

Article in Russian | MEDLINE | ID: mdl-598526

Subject(s)

Dialysis/methods , Streptolysins/pharmacology , Biopharmaceutics , Dialysis/instrumentation , Ointments

6.

[Assessment of the mechanical contamination of ointments in the process of their preparation]. / K voprosu otsenki mekhanicheskogo zagriazneniia mazei v protsesse ikh prigotovleniia.

Zhurko, V V; Dobrotvorskii, A E.

Farmatsiia ; 26(5): 64-5, 1977.

Article in Russian | MEDLINE | ID: mdl-913634

Subject(s)

Drug Compounding , Drug Contamination , Ointments/analysis , Particle Size , Petrolatum/analysis

7.

[Assessment of the mechanical contamination of powdered drug preparations]. / K voprosu otsenki mekhanicheskogo zagriazneniia poroshkoobraznykh lekarstvennykh preparatov

Zhurko, V V; Dobrotvorskii, A E.

Farmatsiia ; 25(5): 65-9, 1976.

Article in Russian | MEDLINE | ID: mdl-1001489

Subject(s)

Drug Contamination , Powders , Technology, Pharmaceutical/instrumentation , USSR

8.

[Storage life and improvement in the technology of ammoniacal liniment]. / O srokakh khraneniia i sovershenstvovanii tekhnologii ammiachnogo linimenta

Dobrotvorskii, A E; Aliushin, M T.

Farmatsiia ; 24(6): 43-5, 1975.

Article in Russian | MEDLINE | ID: mdl-1218621

Subject(s)

Ammonia/pharmacology , Drug Compounding , Drug Storage , Helianthus , Liniments , Oils/pharmacology , Oleic Acids/pharmacology , Time Factors

9.

[Effect of the degree of dispersion and of the type of ointment base on the skin absorption of hydrocortisone and prednisolone ointments]. / Vliianie stepeni dispersnosti i vida mazevoi osnovy na kozhnuiu absorbtsiiu gidrokortizonovoi i prednizolonovoi mazei

Skripkin, Iu K; Dobrotvorskii, A E; Demidova, N M; Aliushin, M T.

Vestn Dermatol Venerol ; 48(5): 19-21, 1974 May.

Article in Russian | MEDLINE | ID: mdl-4839253

Subject(s)

Anti-Inflammatory Agents/pharmacology , Ointments , Pharmaceutic Aids/pharmacology , Skin Absorption/drug effects , Administration, Topical , Adolescent , Adult , Humans , Hydrocortisone , Prednisolone , Skin Temperature/drug effects

10.

[Treatment of certain dermatoses with hydrocortisone and prednisolone ointments]. / O lechenii nekotorykh dermatozov gidrokortizonovoi i prednizolonovoi maziami

Dobrotvorskii, A E; Demidova, N M.

Vestn Dermatol Venerol ; 48(7): 74-6, 1974.

Article in Russian | MEDLINE | ID: mdl-4607649

Subject(s)

Anti-Inflammatory Agents/therapeutic use , Ointments , Skin Diseases/drug therapy , Administration, Topical , Adult , Chronic Disease , Clinical Trials as Topic , Female , Humans , Hydrocortisone , Male , Middle Aged , Particle Size , Placebos , Prednisolone

11.

[Pharmaceutical factors influencing the release and absorption of salicylic acid from ointments]. / Farmatsevticheskie faktory okazyvaiushchie vliianie na vysvobozhdenie i vsakyvanie salitsilovoi kisloty iz mazei.

Dobrotvorskii, A E.

Farmatsiia ; 22(5): 22-5, 1973.

Article in Russian | MEDLINE | ID: mdl-4754797

Subject(s)

Ointments , Salicylates/metabolism , Skin Absorption , Humans , Pharmaceutic Aids/standards , Technology, Pharmaceutical

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