Enhanced Detection of Suspicious Breast Lesions: A Comparative Study of Full-Field Digital Mammography and Automated Breast Ultrasound in 117 Patients with Core Needle Biopsy.

BACKGROUND This retrospective study from a single center aimed to compare the performance of full-field digital mammography (FFDM) vs automated breast ultrasound (ABUS) in the identification and characterization of suspicious breast lesions in 117 patients who underwent core-needle biopsy (CNB) of the breast. MATERIAL AND METHODS The study involved a group of 301 women. Every patient underwent FFDM followed by ABUS, which were assessed in concordance with BI-RADS (Breast Imaging Reporting and Data System) classification. RESULTS No focal lesions were found in 168 patients. In 133 patients, 117 histopathologically verified focal lesions were found. Among them, 78% appeared to be malignant and 22% benign. ABUS detected 246 focal lesions, including 115 classified as BI-RADS 4 or 5 and submitted to verification, while FFDM revealed 122 lesions, including 75 submitted to verification. The analysis revealed that combined application of both methods caused sensitivity to increase to 100, and improved accuracy improvement. Margin assessments in these examinations are consistent (P<0.00), the lesion's margin type with both methods depends on its malignant or benign character (P<0.03), lesion margins distribution on ABUS depends on estrogen receptor presence (P=0.033), and there was significant correlation between malignant character of the lesion and retraction phenomenon sign (P=0.033). ABUS obtained higher compliance between the size of the lesion in histopathology compared to FFDM (P>0.05). CONCLUSIONS The results shows that ABUS is comparable to FFDM, and even outperforms it in a few of the analyzed categories, suggesting that the combination of these 2 methods may have an important role in breast cancer detection.

Combined Effects of Methyldopa and Baicalein or Scutellaria baicalensis Roots Extract on Blood Pressure, Heart Rate, and Expression of Inflammatory and Vascular Disease-Related Factors in Spontaneously Hypertensive Pregnant Rats.

The aim of the study was to investigate the effect of baicalein or Scutellaria baicalensis root extract interaction with methyldopa in pregnant spontaneously hypertensive rats (SHR) at the pharmacodynamic, molecular, and biochemical levels. The rats, after confirming pregnancy, received baicalein (200 mg/kg/day, p.o.) and extract (1000 mg/kg/day, p.o.), in combination with methyldopa (400 mg/kg/day; p.o.), for 14 consecutive days, 1 h before blood pressure and heart rate measurements. In the heart and placenta from mothers after giving birth to their offspring, mRNA expression of factors related to inflammatory processes (TNF-α, Il-1ß, IL-6) and vascular diseases (TGF-ß, HIF-1α, VEGF, PlGF) was measured. Levels of markers of oxidative stress (superoxide dismutase and malondialdehyde) in the placenta and indicators of myocardial damage (troponin cTnC and cTnI, creatine kinase, myoglobin, and lactate dehydrogenase) in the heart were also assessed. Baicalein co-administered with methyldopa was associated with reduced blood pressure, especially during the first three days. The interactions were more pronounced for such factors as TGF-ß, HIF-1α, VEGF, and PlGF than TNF-α, Il-1ß, and IL-6. Combined application of baicalein and extract with methyldopa may be of value in the development of a new antihypertensive medication intended for patients suffering from preeclampsia or pregnancy-induced hypertension.

The Role of Victim's Resilience and Self-Esteem in Experiencing Internet Hate.

Despite the growing prevalence of research on Internet hate, little is still known about the psychological factors that differentiate those who are negatively affected by being subjected to Internet hate and those who are not affected at all or only to a small degree. In the present studies, we aimed to verify if resilience and self-esteem could be predictors of such responses. A total of 60 public figures (politicians, athletes, and artists; 46.7% women) and 1128 ordinary Internet users (25.1% women) participated in the study. Participants completed The Brief Resilience Scale, The Self-Esteem Scale, and The Internet Hate Concern Scale, which was created for this study, and determined how often they experience hate online. The results showed that the public figures experience Internet hate more often but were less concerned with it than the ordinary Internet users, who received online hate less often, but were more worried about it. In both groups, high self-esteem and high resilience were negative predictors of greater concern with received online hate. Our study is the first step to understanding what makes the difference between people who cope well and are not particularly concerned, and people who are greatly affected by received Internet hate.

Dandelion (Taraxacum officinale L.) as a Source of Biologically Active Compounds Supporting the Therapy of Co-Existing Diseases in Metabolic Syndrome.

Nowadays, many people are struggling with obesity, type 2 diabetes, and atherosclerosis, which are called the scourge of the 21st century. These illnesses coexist in metabolic syndrome, which is not a separate disease entity because it includes several clinical conditions such as central (abdominal) obesity, elevated blood pressure, and disorders of carbohydrate and fat metabolism. Lifestyle is considered to have an impact on the development of metabolic syndrome. An unbalanced diet, the lack of sufficient physical activity, and genetic factors result in the development of type 2 diabetes and atherosclerosis, which significantly increase the risk of cardiovascular complications. The treatment of metabolic syndrome is aimed primarily at reducing the risk of the development of coexisting diseases, and the appropriate diet is the key factor in the treatment. Plant raw materials containing compounds that regulate lipid and carbohydrate metabolism in the human body are investigated. Dandelion (Taraxacum officinale F.H. Wigg.) is a plant, the consumption of which affects the regulation of lipid and sugar metabolism. The growth of this plant is widely spread in Eurasia, both Americas, Africa, New Zealand, and Australia. The use and potential of this plant that is easily accessible in the world in contributing to the treatment of type 2 diabetes and atherosclerosis have been proved by many studies.

Reply to Semin et al. Can Humans Discriminate Horse 'Fear' Chemosignals from Control Chemosignals? Comment on "Sabiniewicz et al. A Preliminary Investigation of Interspecific Chemosensory Communication of Emotions: Can Humans (Homo sapiens) Recognise Fear- and Non-Fear Body Odour from Horses (Equus ferus caballus). Animals 2021, 11, 3499".

Whereas several recent studies demonstrated that some animal species are able to recognize human emotions based on information from body odor [...].

The Dual Nature of Amaranth-Functional Food and Potential Medicine.

The beneficial health-promoting properties of plants have been known to mankind for generations. Preparations from them are used to create recipes for dietary supplements, functional food, and medicinal products. Recently, amaranth has become an area of increasing scientific and industrial interest. This is due to its valuable biological properties, rich phytochemical composition, and wide pharmacological activity. Amaranth is a pseudo-cereal crop with a dual character, combining the features of food and health-promoting product. This paper briefly and concisely reviews the current information on the chemical composition of amaranth, the value of its supplementation, the status of amaranth as a food ingredient as well as its key biological and pharmacological activities. The beneficial biological properties of amaranth preparations described in this paper may be an incentive to conduct further in-depth scientific research in this field and also to promote the development of innovative technologies in the food and cosmetics industry with the use of this plant.

A Preliminary Investigation of Interspecific Chemosensory Communication of Emotions: Can Humans (Homo sapiens) Recognise Fear- and Non-Fear Body Odour from Horses (Equus ferus caballus).

Mammalian body odour conveys cues about an individual's emotional state that can be recognised by conspecifics. Thus far, little attention has been paid to interspecific odour communication of emotions, and no studies have examined whether humans are able to recognise animal emotions from body odour. Thus, the aim of the present study was to address this question. Body odour samples were collected from 16 two-year-old thoroughbred horses in fear and non-fear situations, respectively. The horse odour samples were then assessed by 73 human odour raters. We found that humans, as a group, were able to correctly assign whether horse odour samples were collected under a fear- or a non-fear condition, respectively. Furthermore, they perceived the body odour of horses collected under the fear condition as more intense, compared with the non-fear condition. An open question remains, which is whether humans could simply distinguish between little versus much sweat and between high intensity versus low intensity or were able to recognise horses' fear and non-fear emotions. These results appear to fit the notion that the ability to recognise emotions in other species may present an advantage to both the sender and the receiver of emotional cues, particularly in the interaction between humans and domesticated animals. To conclude, the present results indicate that olfaction might contribute to the human recognition of horse emotions. However, these results should be addressed with caution in light of the study's limitations and only viewed as exploratory for future studies.

Defining Online Hating and Online Haters.

According to a view widely held in the media and in public discourse more generally, online hating is a social problem on a global scale. However, thus far there has been little scientific literature on the subject, and, to our best knowledge, there is even no established scholarly definition of online hating and online haters in the first place. The purpose of this manuscript is to provide a new perspective on online hating by, first, distinguishing online hating from the phenomena it is often confused with, such as trolling, cyberstalking, and online hate speech, and, second, by proposing an operational definition of online hating and online haters based on ethnographic interviews and surveys of the existing scholarly literature.

Stress and self-efficacy as specific predictors of safety at work in the aviation sector.

BACKGROUND: The article addresses the issue of attitudes towards safety at work in the context of subjective variables such as psychological stress and the subjective self-efficacy of workers in the aviation sector. The research was exploratory in nature. It focused on capturing the individual experiences of ground handling staff at Polish and Slovak airports. Among the 326 people surveyed were engineers, firefighters, mechanics and electricians - a crew that works in difficult and threatening working conditions on a daily basis, often experiencing unexpected accidents and breakdowns. The psychosocial factors in industry 4.0 and this branch of industry itself are - according to the authors - verified empirically quite poorly. Taking care of safety at work and strengthening a positive attitude towards safety seems to be a key aspect of management in such units. MATERIAL AND METHODS: The Polish Questionnaire of Attitude towards Safety by M. Znajmiecka-Sikora, the Generalized Self-Efficacy Scale and the Plopa and Makarowski Stress Feeling Questionnaire were used in the research. RESULTS: The statistical analyses carried out, including regression analyses and a model of analysis of mediation between variables, have indicated that this sense of effectiveness is a key positive predictor of every aspect related to strengthening attitudes towards safety (a cognitive aspect [ß = 0.21, p < 0.001], an affective aspect [ß = 0.15, p = 0.001] and a behavioral aspect [ß = 0.15, p = 0.002]), as well as the overall level of attitude towards safety (ß = 0.19, p < 0.001). CONCLUSIONS: The sense of effectiveness is an important mediator between the level of perceived stress and attitudes towards safety, which means that as the subjectively perceived sense of self-efficacy increases, the level of experienced stress decreases and thus the positive attitude towards safe actions and behaviors in the workplace is strengthened. Med Pr. 2021;72(5):479-87.

Predictors of the feeling of stress in the aviation sector.

BACKGROUND: Employees in the aviation sector constitute an especially interesting professional group due to a lack of empirical data on their psychological functioning, and the fact that this industry is currently experiencing a phase of dynamic development. However, taking into consideration the automation and specific qualities of the sector, human resources should be given much more attention as they are constantly challenged and face diverse difficulties at work while cooperating in various organic and non-organic teams. MATERIAL AND METHODS: The study included 326 employees of Pyrzowice (Poland), Szymany (Poland), and Kosice (Slovakia) airports (however, people employed at the Polish airports were predominant, N = 250). The average age of the participants was 39.3 years, and the sample was predominantly male (N = 278, 85.3%). During the research procedure, the following questionnaires were used: the Feeling of Threat in the Workplace Questionnaire, the Feeling of Stress Questionnaire, the 10-Item Personality Inventory, and the Mini-COPE Stress Inventory. RESULTS: The regression analysis indicated that personality variables did not allow for predicting the level of stress. However, the helplessness-oriented style (ß = 0.191, p = 0.004), avoidant behaviors (ß = 0.244, p < 0.001), and the feeling of threat (ß = 0.147, p = 0.009) were significant predictors of the feeling of stress, and their high level corresponded with a higher level of stress. The final model explained 23% of the total variance in the feeling of stress. CONCLUSIONS: Based on the results, practical recommendations should concern developing employees' skills related to monitoring stressors and strengthening proactivity in difficult or threatening situations. Such proactive strategies may decrease the tendency to use avoidant and helplessness-oriented behaviors that may cause a higher level of stress perceived by employees. Also, the authors recommend providing training and support using some cognitive behavioral techniques because it seems that the regular application of those methods supports the development of agency and control while facing challenging situations. Med Pr. 2021;72(5):467-77.

Multiple probabilistic traveling salesman problem in the coordination of drug transportation-In the context of sustainability goals and Industry 4.0.

Improving the effectiveness of route planning, especially in road transport deliveries is a challenge we need to face in the context of advancing climate change and the sustainable development goals. The main aim of the paper is to demonstrate the above average and utilitarian significance of the multiple probabilistic traveling salesman problem (MPTSP) in the coordination and modeling of sustainable product transportation, which is a novelty at the theoretical, conceptual, methodological and empirical level. We propose a new, hybrid algorithm of solving MPTSP instances (it connects harmony search, k-means and 2-opt), which can be successfully used in economic practice for coordination and modeling of Industry 4.0. The effectiveness of proposed approach is tested using a case study of drugs distribution services and datasets obtained from the transportation enterprise located in Poland. The study focuses on the issue of planning routes, with particular emphasis on the changing demand of customers. It should be stressed that this work may be of interest to researchers but also to management practitioners. The value added of this research lies in the innovative modeling the coordination of sustainable drug transportation as an instance of MPTSP and proposing an effective method to solve it. The main research results confirm that proposed method contributes to overall sustainability of studied supply chain.

Two-year prognosis of patients hospitalized for decompensated heart failure in a district general hospital.

BACKGROUND: Patients hospitalized for heart failure (HF) exacerbation tend to have a poor prognosis. Most previous studies were performed in large clinical centers and detailed analyses of patients with HF hospitalized in district general hospitals are lacking. AIMS: The aim of this study was to assess the outcomes of patients admitted with HF exacerbation to a district general hospital. METHODS: We retrospectively enrolled patients hospitalized for HF exacerbation in the years 2010 to 2011 (191 patients) and 2016 to 2017 (203 patients). The primary and secondary endpoints were all­cause mortality and rehospitalization due to HF exacerbation, respectively, within a 2­year follow­up. RESULTS: Compared with patients hospitalized from 2010 to 2011, those hospitalized from 2016 to 2017 had more favorable clinical parameters and more appropriate pharmacological treatment; however, the rate of implantable cardioverter­defibrillator and resynchronization device use remained low. The overall mortality decreased from 44% between 2010 and 2011 to 33% between 2016 and 2017 (P = 0.03), but the number of rehospitalizations increased from 26% to 41%, respectively (P <0.001). Male sex, low systolic blood pressure, symptoms of right HF, and renal dysfunction were independent risk factors for the primary endpoint. Symptoms of right HF, renal dysfunction, left ventricular ejection fraction below 24%, and low systolic blood pressure independently predicted the secondary endpoint. CONCLUSIONS: The prognosis of patients hospitalized for decompensated HF in a regional district hospital was poor. Despite some improvement in pharmacological treatment, which probably led to reduced all­­cause mortality, there was a low rate of implantable electronic device use and a high rate of rehospitalizations due to HF exacerbation, which needs further elucidation.

Differential Influence of Pueraria lobata Root Extract and Its Main Isoflavones on Ghrelin Levels in Alcohol-Treated Rats.

The study was carried out on alcohol-preferring male Wistar rats. The following drugs were repeatedly (28×) administered: acamprosate (500 mg/kg, p.o.), naltrexone (0.1 mg/kg, i.p), and Pueraria lobata (kudzu) root extract (KU) (500 mg/kg, p.o.) and its isoflavones: daidzin (40 mg/kg, p.o.) and puerarin (150 mg/kg, p.o.). Their effects on a voluntary alcohol intake were assessed. KU and alcohol were also given for 9 days in an experiment on alcohol tolerance development. Finally, total and active ghrelin levels in peripheral blood serum were measured by ELISA method. Acamprosate, naltrexone, daidzin, and puerarin, reducing the alcohol intake, caused an increase in both forms of ghrelin levels. On the contrary, though KU inhibited the alcohol intake and alcohol tolerance development, it reduced ghrelin levels in alcohol-preferring rats. The changes of ghrelin concentration could play a role as an indicator of the currently used drugs. The other effect on the KU-induced shift in ghrelin levels in the presence of alcohol requires further detailed study.

The Effect of Different Water Extracts from Platycodon grandiflorum on Selected Factors Associated with Pathogenesis of Chronic Bronchitis in Rats.

The aim of this study was to assess the activity of extracts from Platycodon grandiflorum A. DC (PG) in a model of chronic bronchitis in rats. The research was carried out on three water extracts: E1 - from roots of field cultivated PG; E2 - from biotransformed roots of PG; E3 - from callus of PG. The extracts differed in saponins and inulin levels-the highest was measured in E3 and the lowest in E1. Identification of secondary metabolites was performed using two complementary LC-MS systems. Chronic bronchitis was induced by sodium metabisulfite (a source of SO2). Animals were treated with extracts for three weeks (100 mg/kg, intragastrically) and endothelial growth factor (VEGF), transforming growth factors (TGF-ß1, -ß2, -ß3), and mucin 5AC (MUC5AC) levels were determined in bronchoalveolar lavage fluid, whereas C reactive protein (CRP) level was measured in serum. Moreover, mRNA expression were assessed in bronchi and lungs. In SO2-exposed rats, an elevation of the CRP, TGF-ß1, TGF-ß2, VEGF, and mucin was found, but the extracts' administration mostly reversed this phenomenon, leading to control values. The results showed a strong anti-inflammatory effect of the extracts from PG.

Polymorphism analysis of the Gly972Arg IRS-1 and Gly1057Asp IRS-2 genes in obese pregnant women.

Genes encoding insulin receptor substrates IRS-1 and IRS-2 perform key functions in the insulin pathway. Numerous authors have suggested that single-nucleotide polymorphism (SNP) changes in the DNA sequence may be associated with the development of obesity, insulin resistance and type 2 diabetes. The Gly972Arg polymorphism of the IRS-1 gene and the Gly1057Asp polymorphism of the IRS-2 gene are believed to be associated with the occurrence of insulin resistance and obesity according to many sources. The aim of our study was to investigate the influence of these polymorphisms on the clinical parameters and to assess their correlations in obese Polish pregnant women. A total of 154 pregnant Caucasian women from the Wielkopolska region were analyzed: 78 diagnosed with overweight or obesity (study group) and 76 with normal body mass (controls). The analysis of the polymorphisms was performed using the PCR-restriction fragment length polymorphism (PCR-RFLP) method. The IRS-2 Gly1057Asp polymorphism revealed no significant correlations with excessive weight gain during pregnancy. The analysis of the IRS-1 Gly972Arg polymorphism showed an association with obesity between the study and control groups (GG-80.77%, GR-17.95%, RR-1.28% vs GG-94.74%, GR-5.26%; p = 0.023). We also observed slightly increased BMI values ​​and higher values ​​of the waist and hip circumference before pregnancy in the case of the IRS-1 Gly972Arg polymorphism. The analysis of the clinical and anthropometric parameters demonstrated no significant relationships between the genotypes of the polymorphic variants of the IRS-1 and IRS-2 genes but suggested an association between the IRS-1 Gly972Arg polymorphism and the risk for obesity.

Environmental Impact of Burning Composite Materials Used in Aircraft Construction on the Air.

The negative impact of air incidents and emergency situations results from the leakage of liquids into the soil and water and the leakage of flue gases and combustion products of aircraft structural materials into the air during fires. This article deals with air pollution caused by the combustion of composite materials commonly used in general aviation. Samples of composite materials of aircraft registered in the Czech Republic were selected. These samples of composite materials were tested for flammability, according to ISO 5660-1:2002 Reaction to fire tests-Heat Release, smoke production and mass loss rate (ISO-International Organization for Standardization). Total smoke release and total oxygen consumed were assessed in this study, both of which have a significant impact on air quality in the case of an air incident. Based on the results of the research, differences resulting from the diversity of the structures of the tested composite materials were found. The most hazardous composite material was evaluated from the point of view of its impact on air quality during combustion.

Band Structure Engineering of Layered WSe2 via One-Step Chemical Functionalization.

Chemical functionalization is demonstrated to enhance the p-type electrical performance of two-dimensional (2D) layered tungsten diselenide (WSe2) field-effect transistors (FETs) using a one-step dipping process in an aqueous solution of ammonium sulfide [(NH4)2S(aq)]. Molecularly resolved scanning tunneling microscopy and spectroscopy reveal that molecular adsorption on a monolayer WSe2 surface induces a reduction of the electronic band gap from 2.1 to 1.1 eV and a Fermi level shift toward the WSe2 valence band edge (VBE), consistent with an increase in the density of positive charge carriers. The mechanism of electronic transformation of WSe2 by (NH4)2S(aq) chemical treatment is elucidated using density functional theory calculations which reveal that molecular "SH" adsorption on the WSe2 surface introduces additional in-gap states near the VBE, thereby, inducing a Fermi level shift toward the VBE along with a reduction in the electronic band gap. As a result of the (NH4)2S(aq) chemical treatment, the p-branch ON-currents (ION) of back-gated few-layer ambipolar WSe2 FETs are enhanced by about 2 orders of magnitude, and a ∼6× increase in the hole field-effect mobility is observed, the latter primarily resulting from the p-doping-induced narrowing of the Schottky barrier width leading to an enhanced hole injection at the WSe2/contact metal interface. This (NH4)2S(aq) chemical functionalization technique can serve as a model method to control the electronic band structure and enhance the performance of devices based on 2D layered transition-metal dichalcogenides.

Judgment of the morality of an individual responsible for a fatal workplace accident involving subordinates

Background: The aim of the study was to verify the hypothesis that additional information about the perpetrator responsible for the death of subordinates at the workplace may influence the assessment of morality. The article contains the results of an empirical study conducted among young adult working Silesians (N = 262), who were asked to evaluate the morality of the person responsible for the decision, in line with which miners had started working on 6th October 2014. On that day miners died following an explosion in the "Myslowice-Wesola" methane mine in the Polish Silesia region. Material and Methods: The study explored the stories' method (from the moral psychology domain) as well as a short questionnaire. The respondents received information about the behavior of the perpetrator as well as emotions (socially desirable and undesirable) and (socially desirable and undesirable) views in the form of brief descriptions (stories). They were asked to evaluate the perpetrator's morality. Results: The socially desirable views of the evaluated perpetrator (lack of acceptance for the situation) and the socially desirable emotions (guilt) significantly increased the level of morality according to participants. A single piece of information about the socially desirable emotions didn't significantly increase the perceived level of perpetrator's morality; neither did a single piece of information about socially desirable views. Conclusions: Results indicate the important role of additional information about emotions and views of the perpetrator in the process of assessing morality. It is worthwhile to implement the practical implications of this study in similar crisis situations at the workplace. Med Pr 2018;69(3):261­267.

[Assessment of worklife areas and stress intensity among Border Guard officers]. / Ocena obszarów zycia zawodowego funkcjonariuszy Strazy Granicznej a nasilenie stresu.

BACKGROUND: Stress is associated with the performance of high-risk occupations. It can be defined as a set of reactions that results from mismatched working conditions and requirements to capabilities of an employee. People who differently assess these areas of work may experience varying degrees of stress. MATERIAL AND METHODS: The total of 128 Border Guard officers took part in the test. A subjective assessment of areas of work was made by using the Areas of Worklife Survey. The Perceived Stress Scale (PSS-10) was used to examine the severity of stress. RESULTS: Three groups of examined people, differing significantly in the assessment of all areas of working life, were identified. Affiliation of the examined people to these groups explains 8% of the variability in the severity of stress. The results of the regression analysis allowed to consider the assessments of 3 areas of working life (control, rewards and workload) as important predicators of the severity of stress experienced by officers. The model turned out to be statistically significant, the variables included in the model explain 19% of the variability of the dependent variable. CONCLUSIONS: The officers who assess the areas of working life differently, differ in terms of severity of the experienced stress. The severity of stress is significantly related to the ability to make independent decisions and to enjoy rewards. The stress experienced by Border Guard officers is mainly related to the assessment of the following areas of work: sense of control, rewards and workload. Med Pr 2018;69(2):199-210.