ABSTRACT
One of important components of endogenous intoxication in acute pancreatitis is considered to be middle-mass molecules possessing high toxicity. Hemosorption improves results of complex therapy and reduces postoperative lethality by 10% at an average. The positive effect of hemosorption in focal pancreanecrosis is associated with sorption of lipase, trypsin, middle-mass molecules and other metabolites. In total pancreanecroses the effect of hemosorption was minimal. In hemosorption on the sorbent SKN the oxygenation and regional heparinization of the sorbent is indicated.
Subject(s)
Endotoxins/blood , Hemoperfusion , Pancreatitis/complications , Toxemia/therapy , Acute Disease , Animals , Cats , Charcoal , Humans , Male , Mice , Middle AgedABSTRACT
Extracorporal perfusion of the porcine xenospleen was used by the authors in 5 patients with purulent surgical diseases complicated by a septic reaction. Recovery was noted in 2 patients. In one of the patients the extracorporal perfusion of the xenospleen was used in a systemic lupus erythematosus complicated by vasculitic destruction of soft tissues with septic reaction. The effect was positive. The extracorporal perfusion of the porcine xenospleen is considered by the authors to be an effective method of detoxication of organism of patients with septic complications.