[Electron-radioautographic study of differential influence of biologically active wound covering on the process of regeneration]. / élektronno-radiographicheskoe issledovanie differentsirovannogo vliianiia biologicheski aktivnykh ranevykh pokrytii ha protsessy regeneratsii.

It is established that local wound treatment with coverings is directed to both suppression of microflora and inflammatory process and stimulation of regeneration at early periods of wound healing, this favouring granulation tissues growth and wound epithelization. Mechanism of biologically active covering influence on the reparative regeneration lies in stimulation of fibroblast, endotheliocyte and pericyte proliferation and stimulation of granulation tissue cells functional activity.

[Development of new biologically active dressings and methodology of their use]. / Razrabotka novykh biologicheski aktivnykh pereviazochnykh sredstv i metodologiia ikh primeneniia.

Results of development of new biologically active dressings and up-to-date methodology of local treatment of wounds (based on their differential application according to phase and features of wound process) are demonstrated. Data about main properties and specific activity of new biologically active dressings based on natural and synthetic polymers with immobilized drugs are presented. Future trends and efficacy of their appliance in complex treatment of purulent and necrotic wounds are demonstrated.

Specific effect of epidermal growth factor immobilized on wound coating with soluble collagen on healing of experimental wounds.

Electron-microscopy and autoradiography of granulation tissue in wounds showed that bioactive coating with epidermal growth factor activates functional and proliferative processes in vascular cells (endotheliocytes and pericytes) and fibroblasts and increases the number of cell-to-cell contacts on days 2-3 of therapy. Pronounced activation of proliferative processes resulted in early differentiation of fibroblast cells (on days 3-4) and rapid epithelialization of the wound.

[A comparative study of charcoal sorbents for local wound treatment]. / Sravnitel'noe izuchenie uglerodnykh sorbentov dlia mestnogo lecheniia ran.

The laboratory and medico-biological findings made it possible to choose the most suitable carbonaceous sorbents for local management of wounds, basing on the fact that every carbonaceous material has strictly selected capacity for protein and microbe sorption, and also can be the carrier of the water-miscible drugs. The "Dnieper-MN" carbonaceous fabric and "Aktilen" fibrous sorbent have the best features for sorption. It is possible to use these materials for the construction of bandages to treat wounds and burns which have little exudation. "Karpema" and "AUTM-2" sorbents, which are characterized by the low degree of activation, can be used for the manufacturing of surgical pads. "Karpema" being strong and having a less fiber structure, has a good electrical conductivity and, thus, can be used as medical electrodes.

[Effective forms of surgical dressing materials produced by the Paul Hartman firm]. / Effektivnye formy khirurgicheskikh pereviazochnykh sredstv firmy "Paul' Khartman".

From study of gauze dressings produced by the Paul Hartman firm the authors analyse the approaches to their elaboration. It is shown that the use of industrially sterilized gauze dressing-material creates the condition for fruitful work of the surgeon and ensures economy of the gauze. Concrete problems of the production of modern gauze dressing material by Soviet industry are defined.

[Testing of promising dressing materials in cultures of fibroblasts and keratinocytes of human skin]. / Testirovanie perspektivnykh pereviazochnykh materialov na kul'turakh fibroblastov i keratinotsitov kozhi cheloveka.

Cell cultures of epidermal keratinocytes and dermal fibroblasts were used to test collagen dressings in vitro. It was shown that effects of the dressings on skin major cell types might be differentially evaluated.

[The results of laboratory research on powdered medical sorbents and the prospects for their use in surgery]. / Rezul'taty laboratornogo issledovaniia poroshkoobraznykh sorbentov i perspektivy ikh ispol'zovaniia v khirurgii.

The sorption-application therapy is of great medico-prophylactic significance in treatment of military trauma. The medical effect can be obtained but when using sorbents maintaining the active mechanism of debridement of the wounds. On the basis of the complex laboratory investigation of properties of the sorption materials and their ultrastructure conclusions are made of prerequisites for their use in treatment of purulent wounds. It was shown that the curative-prophylactic effectiveness can be provided by sorbents on the basis of water-swollen polymers (Gelevin, Cellosorb, Gelecel) and carbohydrate materials.