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1.
Nat Commun ; 9(1): 4763, 2018 11 12.
Article in English | MEDLINE | ID: mdl-30420659

ABSTRACT

Current methods for generating liquid-liquid interfaces with either controlled composition or coverage often rely on adsorption equilibria which limits the freedom to design such multiphase materials, in particular when different components are used. Moreover, when interfaces become densely populated, slowing down of adsorption may impose additional constraints. Up to now, it is not possible to control surface coverage and composition of droplet interfaces at will. Here, we report a generic and versatile method to create designer liquid-liquid interfaces, using transient double emulsions. We demonstrate how the surface coverage in Pickering emulsions can be controlled at will, even for dense particulate layers going up to multilayers. Moreover, composite droplet interfaces with compositional control can be generated, even with particles which would have intrinsically different or even opposite adsorption characteristics. Given its simplicity, this method offers a general approach for control of composition of liquid-liquid interfaces in a variety of multiphase systems.

2.
Biomicrofluidics ; 10(4): 043506, 2016 Jul.
Article in English | MEDLINE | ID: mdl-27462382

ABSTRACT

A geometrically simple flow cell is proposed to generate different types of stagnation flows, using a separation flow and small variations of the geometric parameters. Flows with high local deformation rates can be changed from purely rotational, over simple shear flow, to extensional flow in a region surrounding a stagnation point. Computational fluid dynamic calculations are used to analyse how variations of the geometrical parameters affect the flow field. These numerical calculations are compared to the experimentally obtained streamlines of different designs, which have been determined by high speed confocal microscopy. As the flow type is dictated predominantly by the geometrical parameters, such simple separating flow devices may alleviate the requirements for flow control, while offering good stability for a wide variety of flow types.

3.
Ann Clin Biochem ; 52(Pt 2): 283-7, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25205856

ABSTRACT

We report a case of an ethanol and massive gamma-butyrolactone (GBL) intoxication, the precursor of the recreational drug gamma-hydroxybutyric acid (GHB), resulting in life-threatening metabolic acidosis (pH 6.5) with a highly increased anion- and osmolal gap. Rapid analysis using gas chromatography revealed a GHB plasma concentration of 4400 mg/L, far above the upper limit concentration of 1000 mg/L found in adult fatalities attributed to GBL. Full recovery was established following supportive treatment including haemodialysis. This is the first report of a combined ethanol/GBL intoxication as a cause of high serum anion- and osmolal-gap metabolic acidosis.


Subject(s)
4-Butyrolactone/toxicity , Acidosis/etiology , Alcoholic Intoxication/physiopathology , Drug Overdose/physiopathology , Illicit Drugs/toxicity , 4-Butyrolactone/blood , Acidosis/metabolism , Acidosis/physiopathology , Acidosis/therapy , Alcoholic Intoxication/complications , Coma/etiology , Combined Modality Therapy , Cyanosis/etiology , Drug Overdose/complications , Emergency Medical Services , Humans , Illicit Drugs/blood , Male , Renal Dialysis , Severity of Illness Index , Treatment Outcome
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