Medical brain drain: How many, where and why?

We build a new database documenting the evolution of physician migration over a period of 25 years (1990-2014), and use it to empirically shed light on its determinants. In relative terms, the highest emigration rates are observed in small island nations and low-income countries, where needs-based deficits of healthcare workers are often estimated to be most severe. Over time, we identify rising trends in Caribbean islands, Central Asia and Eastern Europe. On the contrary, despite increasing migration flows to Western Europe, physician migration rates from sub-Saharan Africa have been stable or even decreasing. Our empirical analysis reveals that physician migration is a complex phenomenon that results from a myriad of push, pull, and dyadic factors. It is strongly affected by the economic characteristics of origin and destination countries. The sensitivity to these push and pull factors is governed by linguistic and geographic ties between countries. Interestingly, we find that the evolution of medical brain drain is affected by immigration policies aimed at attracting high-skilled workers. In particular, physician migration is sensitive to visa restrictions, diploma recognition, points-based system, tax breaks towards migrants, and the option of obtaining a permanent resident status.

International migration and the propagation of HIV in sub-Saharan Africa.

In this paper, we identify and quantify the role of international migration in the propagation of HIV across sub-Saharan African countries. We use panel data on bilateral migration flows and HIV prevalence rates covering 44 countries after 1990. Controlling for unobserved heterogeneity, reverse causality, reflection issues, incorrect treatment of country fixed effects and spatial autocorrelation, we find evidence of a highly robust emigration-induced propagation mechanism. On the contrary, immigration has no significant effect. Numerical experiments reveal that the long-run effect of emigration accounts for more than 4 percent of the number of HIV cases in 15 countries (and more than 20 percent in 6 countries).

BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours.

BORIS (for brother of the regulator of imprinted sites), a paralogue of the transcription factor, CTCF, is a novel member of the cancer-testis antigen family. The aims of the present study were as follows: (1) to investigate BORIS expression in breast cells and tumours using immunohistochemical staining, western and real-time RT-PCR analyses and (2) assess potential correlation between BORIS levels in tumours with clinical/pathological parameters. BORIS was detected in all 18 inspected breast cell lines, but not in a primary normal breast cell culture. In 70.7% (41 of 58 cases) BORIS was observed in breast tumours. High levels of BORIS correlated with high levels of progesterone receptor (PR) and oestrogen receptor (ER). The link between BORIS and PR/ER was further confirmed by the ability of BORIS to activate the promoters of the PR and ER genes in the reporter assays. Detection of BORIS in a high proportion of breast cancer patients implies potential practical applications of BORIS as a molecular biomarker of breast cancer. This may be important for diagnosis of the condition and for the therapeutic use of BORIS. The ability of BORIS to activate promoters of the RP and ER genes points towards possible involvement of BORIS in the establishment, progression and maintenance of breast tumours.

The 35UZ transposon of Drosophila melanogaster reveals differences in maintenance of transcriptional control between embryonic and larval stages.

The D. melanogaster transposon P[35UZ] contains a lacZ reporter gene fused to 35 kb of Ubx upstream sequences which drive a Ubx-like expression in embryos and in metathoracic imaginal discs. Transposition of P[35UZ] followed by analysis of different lines in wild-type and mutant backgrounds allowed us to analyze the interplay between Ubx regulatory elements, including the Polycomb response element (PRE), located inside the transposon and cis-acting regulatory elements, located outside. We found that all lines show a Ubx-like beta-galactosidase expression pattern in the embryo, but proximity to strong imaginal enhancers can change this pattern drastically. These data illustrate how maintenance of gene expression depends on the chromosomal environment and on dynamic interactions between all developmentally regulated enhancers located close to a promoter under PcG control.

Are migrant minorities strategically self-selected?

"In this paper we focus on the possibility of migrants' self-selection through strategic remittances. We argue that migrants of a specific community might be pooled with migrants from other ethnic minorities on the labor market of the foreign host country and that this could reduce the occurrence of strategic remittances. In a simple model with two types of workers, skilled and unskilled, facing two possible actions, to migrate or not to migrate, we derive the theoretical conditions under which strategic transfers are still operating when pooling among communities is introduced."